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Phase I and Clinical Pharmacology

Citations 1-25 of 152 total displayed.

Immunotherapy
Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma
Adil I. Daud, Ronald C. DeConti, Stephanie Andrews, Patricia Urbas, Adam I. Riker, Vernon K. Sondak, Pamela N. Munster, Daniel M. Sullivan, Kenneth E. Ugen, Jane L. Messina, and Richard Heller
J. Clin. Oncol. 2008; 26: 5896-5903. [Abstract] [Full text] [PDF]  

Immunotherapy
Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma
Adil I. Daud, Ronald C. DeConti, Stephanie Andrews, Patricia Urbas, Adam I. Riker, Vernon K. Sondak, Pamela N. Munster, Daniel M. Sullivan, Kenneth E. Ugen, Jane L. Messina, and Richard Heller
J. Clin. Oncol. 2008; 26: 5896-5903. [Abstract] [Full text] [PDF]  

Commentary
Retinol, Vitamins, and Cancer Prevention: 25 Years of Learning and Relearning
Gary E. Goodman, David S. Alberts, and Frank L. Meyskens
J. Clin. Oncol. 2008; 26: 5495-5496. [Full text] [PDF]  

Editorials
Targeting Polo-Like Kinase: Learning Too Little Too Late?
David Olmos, Charles Swanton, and Johann de Bono
J. Clin. Oncol. 2008; 26: 5497-5499. [Full text] [PDF]  

Phase I and Clinical Pharmacology
Phase I Study of ON 01910.Na, a Novel Modulator of the Polo-Like Kinase 1 Pathway, in Adult Patients With Solid Tumors
Antonio Jimeno, Jing Li, Wells A. Messersmith, Daniel Laheru, Michelle A. Rudek, Manoj Maniar, Manuel Hidalgo, Sharyn D. Baker, and Ross C. Donehower
J. Clin. Oncol. 2008; 26: 5504-5510. [Abstract] [Full text] [PDF]  

Phase I and Clinical Pharmacology
Phase I Dose Escalation and Pharmacokinetic Study of BI 2536, a Novel Polo-Like Kinase 1 Inhibitor, in Patients With Advanced Solid Tumors
Klaus Mross, Annette Frost, Simone Steinbild, Susanne Hedbom, Jochen Rentschler, Rolf Kaiser, Nicolas Rouyrre, Dirk Trommeshauser, Cornelia E. Hoesl, and Gerd Munzert
J. Clin. Oncol. 2008; 26: 5511-5517. [Abstract] [Full text] [PDF]  

Immunotherapy
Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma
Adil I. Daud, Ronald C. DeConti, Stephanie Andrews, Patricia Urbas, Adam I. Riker, Vernon K. Sondak, Pamela N. Munster, Daniel M. Sullivan, Kenneth E. Ugen, Jane L. Messina, and Richard Heller
J. Clin. Oncol. 10.1200/JCO.2007.15.6794. [Abstract] [PDF]  

Commentary
High-Dose Etoposide: From Phase I to a Component of Curative Therapy
Steven N. Wolff, John D. Hainsworth, and F. Anthony Greco
J. Clin. Oncol. 2008; 26: 5310-5312. [Full text] [PDF]  

Editorials
Exploiting the Apoptotic Route for Cancer Treatment: A Single Hit Will Rarely Result in a Home Run
Elisabeth G.E. de Vries and Steven de Jong
J. Clin. Oncol. 2008; 26: 5151-5153. [Full text] [PDF]  

Phase I and Clinical Pharmacology
Phase I and Pharmacokinetic Study of YM155, a Small-Molecule Inhibitor of Survivin
Anthony W. Tolcher, Alain Mita, Lionel D. Lewis, Christopher R. Garrett, Elizabeth Till, Adil I. Daud, Amita Patnaik, Kyri Papadopoulos, Chris Takimoto, Pamela Bartels, Anne Keating, and Scott Antonia
J. Clin. Oncol. 2008; 26: 5198-5203. [Abstract] [Full text] [PDF]  

Commentary
Retinol, Vitamins, and Cancer Prevention: 25 Years of Learning and Relearning
Gary E. Goodman, David S. Alberts, and Frank L. Meyskens
J. Clin. Oncol. 10.1200/JCO.2008.19.0884. [Abstract] [PDF]  

Editorial
Targeting Polo-Like Kinase: Learning Too Little Too Late?
David Olmos, Charles Swanton, and Johann de Bono
J. Clin. Oncol. 10.1200/JCO.2008.18.6585. [Abstract] [PDF]  

Phase I and Clinical Pharmacology
Phase I Study of ON 01910.Na, a Novel Modulator of the Polo-Like Kinase 1 Pathway, in Adult Patients With Solid Tumors
Antonio Jimeno, Jing Li, Wells A. Messersmith, Daniel Laheru, Michelle A. Rudek, Manoj Maniar, Manuel Hidalgo, Sharyn D. Baker, and Ross C. Donehower
J. Clin. Oncol. 10.1200/JCO.2008.17.9788. [Abstract] [PDF]  

Phase I and Clinical Pharmacology
Phase I Dose Escalation and Pharmacokinetic Study of BI 2536, a Novel Polo-Like Kinase 1 Inhibitor, in Patients With Advanced Solid Tumors
Klaus Mross, Annette Frost, Simone Steinbild, Susanne Hedbom, Jochen Rentschler, Rolf Kaiser, Nicolas Rouyrre, Dirk Trommeshauser, Cornelia E. Hoesl, and Gerd Munzert
J. Clin. Oncol. 10.1200/JCO.2008.16.1547. [Abstract] [PDF]  

Commentary
High-Dose Etoposide: From Phase I to a Component of Curative Therapy
Steven N. Wolff, John D. Hainsworth, and F. Anthony Greco
J. Clin. Oncol. 10.1200/JCO.2008.19.0892. [Abstract] [PDF]  

Genitourinary Cancer
Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms That Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven
Gerhardt Attard, Alison H.M. Reid, Timothy A. Yap, Florence Raynaud, Mitch Dowsett, Sarah Settatree, Mary Barrett, Christopher Parker, Vanessa Martins, Elizabeth Folkerd, Jeremy Clark, Colin S. Cooper, Stan B. Kaye, David Dearnaley, Gloria Lee, and Johann S. de Bono
J. Clin. Oncol. 2008; 26: 4563-4571. [Abstract] [Full text] [PDF]  

Editorials
Exploiting the Apoptotic Route for Cancer Treatment: A Single Hit Will Rarely Result in a Home Run
Elisabeth G.E. de Vries and Steven de Jong
J. Clin. Oncol. 10.1200/JCO.2008.18.3160. [Abstract] [PDF]  

Phase I and Clinical Pharmacology
Phase I and Pharmacokinetic Study of YM155, a Small-Molecule Inhibitor of Survivin
Anthony W. Tolcher, Alain Mita, Lionel D. Lewis, Christopher R. Garrett, Elizabeth Till, Adil I. Daud, Amita Patnaik, Kyri Papadopoulos, Chris Takimoto, Pamela Bartels, Anne Keating, and Scott Antonia
J. Clin. Oncol. 10.1200/JCO.2008.17.2064. [Abstract] [PDF]  

Phase I and Clinical Pharmacology
Phase I Study of Adenovirus p53 Administered by Bronchoalveolar Lavage in Patients With Bronchioloalveolar Cell Lung Carcinoma: ECOG 6597
Vicki Keedy, Wei Wang, Joan Schiller, Sunil Chada, Bonnie Slovis, Keith Coffee, John Worrell, Lyn A. Thet, David H. Johnson, and David P. Carbone
J. Clin. Oncol. 2008; 26: 4166-4171. [Abstract] [Full text] [PDF]  

Phase I and Clinical Pharmacology
Pharmacodynamic-Guided Modified Continuous Reassessment Method–Based, Dose-Finding Study of Rapamycin in Adult Patients With Solid Tumors
Antonio Jimeno, Michelle A. Rudek, Peter Kulesza, Wen Wee Ma, Jenna Wheelhouse, Anna Howard, Yasmin Khan, Ming Zhao, Heather Jacene, Wells A. Messersmith, Daniel Laheru, Ross C. Donehower, Elizabeth Garrett-Mayer, Sharyn D. Baker, and Manuel Hidalgo
J. Clin. Oncol. 2008; 26: 4172-4179. [Abstract] [Full text] [PDF]  

Clinical Research
Performing Nondiagnostic Research Biopsies in Irradiated Tissue: A Review of Scientific, Clinical, and Ethical Considerations
Aaron P. Brown, David S. Wendler, Kevin A. Camphausen, Franklin G. Miller, and Deborah Citrin
J. Clin. Oncol. 2008; 26: 3987-3994. [Abstract] [Full text] [PDF]  

Editorials
Challenges and Pitfalls of Combining Targeted Agents in Phase I Studies
Stephen A. Cannistra
J. Clin. Oncol. 2008; 26: 3665-3667. [Full text] [PDF]  

Phase I and Clinical Pharmacology
Combination Targeted Therapy With Sorafenib and Bevacizumab Results in Enhanced Toxicity and Antitumor Activity
Nilofer S. Azad, Edwin M. Posadas, Virginia E. Kwitkowski, Seth M. Steinberg, Lokesh Jain, Christina M. Annunziata, Lori Minasian, Gisele Sarosy, Herbert L. Kotz, Ahalya Premkumar, Liang Cao, Deborah McNally, Catherine Chow, Helen X. Chen, John J. Wright, William D. Figg, and Elise C. Kohn
J. Clin. Oncol. 2008; 26: 3709-3714. [Abstract] [Full text] [PDF]  

Clinical Trials
Phase II Stopping Rules That Employ Response Rates and Early Progression
John R. Goffin and Dongsheng Tu
J. Clin. Oncol. 2008; 26: 3715-3720. [Abstract] [Full text] [PDF]  

Articles
Phase I Clinical Trial of a Selective Inhibitor of CYP17, Abiraterone Acetate, Confirms That Castration-Resistant Prostate Cancer Commonly Remains Hormone Driven
Gerhardt Attard, Alison H.M. Reid, Timothy A. Yap, Florence Raynaud, Mitch Dowsett, Sarah Settatree, Mary Barrett, Christopher Parker, Vanessa Martins, Elizabeth Folkerd, Jeremy Clark, Colin S. Cooper, Stan B. Kaye, David Dearnaley, Gloria Lee, and Johann S. de Bono
J. Clin. Oncol. 10.1200/JCO.2007.15.9749. [Abstract] [PDF]  

Review Article
Ligand-Based Targeting of Apoptosis in Cancer: The Potential of Recombinant Human Apoptosis Ligand 2/Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (rhApo2L/TRAIL)
Avi Ashkenazi, Pamela Holland, and S. Gail Eckhardt
J. Clin. Oncol. 2008; 26: 3621-3630. [Abstract] [Full text] [PDF]  

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