Journal of Clinical Oncology, Vol 1, 645-651, Copyright © 1983 by American Society of Clinical Oncology
Combination cisplatin, vinblastine, and bleomycin chemotherapy (PVB) for malignant germ-cell tumors of the ovary
RW Carlson, BI Sikic, MM Turbow and SC Ballon
Nine women with germ-cell tumors of the ovary (three endodermal sinus
tumors, four immature teratomas, and two mixed germ-cell tumors) were
treated with cisplatin, vinblastine, and bleomycin (PVB) chemotherapy after
cytoreductive operations. Five patients were stage I, three were stage III,
and one patient had recurrent disease. All nine women are alive and without
evidence of disease with a median follow-up of 31 months from diagnosis and
27 months since completion of PVB. Treatment toxicity although occasionally
severe was rapidly reversible.
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