Journal of Clinical Oncology, Vol 15, 1348-1353, Copyright © 1997 by American Society of Clinical Oncology
Evaluation of irradiated heart volumes in stage I breast cancer patients treated with postoperative adjuvant radiotherapy
G Gyenes, G Gagliardi, I Lax, T Fornander and LE Rutqvist
Department of Oncology, Southern Hospital, Stockholm, Sweden. gyengab@bcl3.sote.hu
PURPOSE: To quantify the proportion of heart volumes that received at least
25 Gy with tangential photon fields in patients with left-sided stage I (T1
NOMO) breast cancer treated with breast-conserving surgery. METHODS AND
MATERIALS: The dose planning of 100 consecutive patients was reviewed. All
were irradiated with tangential photon fields that covered the left breast
only. A three-dimensional computed tomographic (CT)-based dose planning was
made for each patient. The prescribed dose to the tumor was 50 Gy. For each
patient, the proportion of the heart included in the 50% isodose was
determined from the cumulative dose- volume histogram (DVH). The same
volume determination was made for the left-sided breast cancer patients
treated with tangential fields during the first Stockholm Breast Cancer
Trial. RESULTS: The mean irradiated heart volume that received at least 25
Gy was 5.7% (SD = 4.5%) for the whole group and 11.9% (SD = 3.7%) in those
with the highest volumes. The mean irradiated heart volume included in the
50% isodose for patients in the Stockholm Trial was 25% (SD = 11.9%).
CONCLUSION: In this study, the majority of patients with left-sided T1NOMO
breast cancer did not receive irradiation to substantial heart volumes.
However, in 6% of all studied patients, the proportion of irradiated heart
volume was close to the irradiated heart volumes with one of the treatment
techniques used in the Stockholm Trial for patients with left- sided
tumors. That technique has been associated with significantly increased
cardiac mortality during long-term follow-up evaluation in a previous
study. The CT-based three-dimensional treatment-planning system (TMS)
represents a valuable tool in identifying such patients; thus, treatment
may be conformed to reduce the irradiated heart volume.
This article has been cited by other articles:
|
|
|
|
 
E. E. R. Harris, C. Correa, H. Litt, W.-T. Hwang, V. Ferrari, and L. Solin
In Reply:
J. Clin. Oncol.,
March 10, 2008;
26(8):
1390 - 1392.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. R. Correa, H. I. Litt, W.-T. Hwang, V. A. Ferrari, L. J. Solin, and E. E. Harris
Coronary Artery Findings After Left-Sided Compared With Right-Sided Radiation Treatment for Early-Stage Breast Cancer
J. Clin. Oncol.,
July 20, 2007;
25(21):
3031 - 3037.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Gyenes
Late Cardiac Morbidity and Mortality in Early-Stage Breast Cancer Patients After Breast-Conservation Treatment
J. Clin. Oncol.,
June 10, 2007;
25(17):
2489 - 2489.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. C. Formenti, D. Gidea-Addeo, J. D. Goldberg, D. F. Roses, A. Guth, B. S. Rosenstein, and K. J. DeWyngaert
Phase I-II Trial of Prone Accelerated Intensity Modulated Radiation Therapy to the Breast to Optimally Spare Normal Tissue
J. Clin. Oncol.,
June 1, 2007;
25(16):
2236 - 2242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Hooning, A. Botma, B. M. P. Aleman, M. H. A. Baaijens, H. Bartelink, J. G. M. Klijn, C. W. Taylor, and F. E. van Leeuwen
Long-Term Risk of Cardiovascular Disease in 10-Year Survivors of Breast Cancer
J Natl Cancer Inst,
March 7, 2007;
99(5):
365 - 375.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J A Violet and C Harmer
Breast cancer: improving outcome following adjuvant radiotherapy
Br. J. Radiol.,
October 1, 2004;
77(922):
811 - 820.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Venables, E A Miles, A Deighton, E G A Aird, and P J Hoskin
Irradiation of the heart during tangential breast treatment: a study within the START trial
Br. J. Radiol.,
February 1, 2004;
77(914):
137 - 142.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. H. FRIEDLANDER, E. C. SUNG, and J. S. CHILD
Radiation-induced heart disease after Hodgkin's disease and breast cancer treatment: Dental implications
J Am Dent Assoc,
December 1, 2003;
134(12):
1615 - 1620.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
