Journal of Clinical Oncology, Vol 15, 1811-1813, Copyright © 1997 by American Society of Clinical Oncology

ARTICLES

Asymptomatic recurrence detection with surveillance scanning in children with medulloblastoma

DW Shaw, JR Geyer, MS Berger, J Milstein and KL Lindsley
Department of Radiology, Children's Hospital and Medical Center, Seattle, WA 98105, USA. ddshaw@u.washington.edu

PURPOSE: To assess the utility of surveillance neuroimaging in detecting recurrent disease in patients treated for medulloblastoma. PATIENTS AND METHODS: Records and scans of 59 consecutive patients treated for medulloblastoma between 1984 and 1993 in one institution were retrospectively reviewed. RESULTS: Nineteen of 59 patients had recurrence of tumor, of which 17 were available for this study. Eleven of the 17 recurrent patients were asymptomatic at the time of detection. The median time to recurrence was 13 months (range, 3 to 90). CONCLUSION: Surveillance scanning detected a majority of recurrences before onset of symptoms. Although the outcome of those with recurrent disease remains poor, early detection with minimum disease provides the best setting in which to test newer therapies. Patients and their parents also were more likely to elect pursuing further treatment when relapse was detected asymptomatically.

This article has been cited by other articles:

				L.-G. Vezina Imaging of Central Nervous System Tumors in Children: Advances and Limitations J Child Neurol, October 1, 2008; 23(10): 1128 - 1135. [Abstract] [PDF]

				K. K. Koeller and E. J. Rushing From the Archives of the AFIP: Medulloblastoma: A Comprehensive Review with Radiologic-Pathologic Correlation RadioGraphics, November 1, 2003; 23(6): 1613 - 1637. [Abstract] [Full Text] [PDF]

				A. Y. Minn, B. H. Pollock, L. Garzarella, G. V. Dahl, L. E. Kun, J. M. Ducore, A. Shibata, J. Kepner, and P. G. Fisher Surveillance Neuroimaging to Detect Relapse in Childhood Brain Tumors: A Pediatric Oncology Group Study J. Clin. Oncol., November 1, 2001; 19(21): 4135 - 4140. [Abstract] [Full Text] [PDF]

				S. P. Meyers, S. L. Wildenhain, J.-K. Chang, E. C. Bourekas, P. F. Beattie, D. N. Korones, D. Davis, I. F. Pollack, and R. A. Zimmerman Postoperative Evaluation for Disseminated Medulloblastoma Involving the Spine: Contrast-enhanced MR Findings, CSF Cytologic Analysis, Timing of Disease Occurrence, and Patient Outcomes AJNR Am. J. Neuroradiol., October 1, 2000; 21(9): 1757 - 1765. [Abstract] [Full Text]