Journal of Clinical Oncology, Vol 16, 13-18, Copyright © 1998 by American Society of Clinical Oncology
High-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged autologous bone marrow transplantation in mantle-cell lymphoma: no evidence for long-term remission
AS Freedman, D Neuberg, JG Gribben, P Mauch, RJ Soiffer, DC Fisher, KC Anderson, N Andersen, R Schlossman, M Kroon, J Ritz, J Aster and LM Nadler
Division of Hematologic Malignancies and Biostatistics, Dana-Farber Cancer Institute, Boston, MA 02115, USA. arney-freedman@dfci.harvard.edu
PURPOSE: The role for high-dose therapy and autologous stem-cell
transplantation in mantle-cell lymphoma (MCL) is unknown. We
retrospectively analyzed patients with chemosensitive disease who underwent
high-dose chemoradiotherapy and anti-B-cell monoclonal antibody-purged
autologous bone marrow transplantation (ABMT) for MCL in first remission,
as well as following relapse from conventional therapy. PATIENTS AND
METHODS: Between August 1985 and April 1996, 28 patients underwent ABMT
using a uniform ablative regimen with cyclophosphamide and total-body
irradiation (TBI) and a bone marrow- purging regimen. Re-review of original
tissue demonstrated that all patients had morphologic, phenotypic, and
genotypic characteristics of MCL. MCL was the original diagnosis in 21
patients, whereas seven patients had a prior diagnosis of diffuse small
cleaved-cell lymphoma. RESULTS: Twenty patients received multiple regimens
before ABMT, while eight underwent ABMT in first complete remission
(CR)/partial remission (PR) following CHOP induction. At bone marrow
harvest, only 18% of patients were in CR and overt BM infiltration was
present in 57%. Following cyclophosphamide/TBI, no treatment-related deaths
were seen. Nineteen of 28 patients have relapsed at a median time of 21
months (range, 3 to 70). Of eight patients transplanted in first CR/PR,
five have relapsed. Nine patients are in continuous CR with a median
follow- up time of 24 months (range, 10 to 135). Disease-free survival
(DFS) and overall survival (OS) are estimated to be 31% and 62% at 4 years,
respectively. CONCLUSION: ABMT using cyclophosphamide/TBI conditioning may
at best be effective in only a small fraction of patients with relapsed
MCL. The lack of plateau with a median follow-up time of 24 months suggests
cure may not be achievable. The role of this therapy in patients in first
remission requires more study using better induction therapy to enhance the
CR rate before ABMT.
This article has been cited by other articles:
|
|
|
|
 
D. J. Straus
How I Treat Mantle Cell Lymphoma
J. Oncol. Pract,
September 1, 2007;
3(5):
281 - 282.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Lepelletier, V. Camara-Clayette, H. Jin, A. Hermant, S. Coulon, M. Dussiot, M. Arcos-Fajardo, C. Baude, D. Canionni, R. Delarue, et al.
Prevention of Mantle Lymphoma Tumor Establishment by Routing Transferrin Receptor toward Lysosomal Compartments
Cancer Res.,
February 1, 2007;
67(3):
1145 - 1154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Dreger, M. Rieger, B. Seyfarth, M. Hensel, M. Kneba, A. D. Ho, N. Schmitz, and C. Pott
Rituximab-augmented myeloablation for first-line autologous stem cell transplantation for mantle cell lymphoma: effects on molecular response and clinical outcome
Haematologica,
January 1, 2007;
92(1):
42 - 49.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Kahl, W. Longo, J. Eickhoff, J Zehnder, C Jones, J Blank, T McFarland, W Bottner, H Rezazedeh, J Werndli, et al.
Maintenance rituximab following induction chemoimmunotherapy may prolong progression-free survival in mantle cell lymphoma: a pilot study from the Wisconsin Oncology Network
Ann. Onc.,
September 1, 2006;
17(9):
1418 - 1423.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Pott, C. Schrader, S. Gesk, L. Harder, M. Tiemann, T. Raff, M. Bruggemann, M. Ritgen, B. Gahn, M. Unterhalt, et al.
Quantitative assessment of molecular remission after high-dose therapy with autologous stem cell transplantation predicts long-term remission in mantle cell lymphoma
Blood,
March 15, 2006;
107(6):
2271 - 2278.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Nademanee, S. Forman, A. Molina, H. Fung, D. Smith, A. Dagis, C. Kwok, D. Yamauchi, A.-L. Anderson, P. Falk, et al.
A phase 1/2 trial of high-dose yttrium-90-ibritumomab tiuxetan in combination with high-dose etoposide and cyclophosphamide followed by autologous stem cell transplantation in patients with poor-risk or relapsed non-Hodgkin lymphoma
Blood,
October 15, 2005;
106(8):
2896 - 2902.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Witzig
Current Treatment Approaches for Mantle-Cell Lymphoma
J. Clin. Oncol.,
September 10, 2005;
23(26):
6409 - 6414.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Witzig, S. M. Geyer, I. Ghobrial, D. J. Inwards, R. Fonseca, P. Kurtin, S. M. Ansell, R. Luyun, P. J. Flynn, R. F. Morton, et al.
Phase II Trial of Single-Agent Temsirolimus (CCI-779) for Relapsed Mantle Cell Lymphoma
J. Clin. Oncol.,
August 10, 2005;
23(23):
5347 - 5356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Dreyling, G. Lenz, E. Hoster, A. Van Hoof, C. Gisselbrecht, R. Schmits, B. Metzner, L. Truemper, M. Reiser, H. Steinhauer, et al.
Early consolidation by myeloablative radiochemotherapy followed by autologous stem cell transplantation in first remission significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network
Blood,
April 1, 2005;
105(7):
2677 - 2684.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Brugger, J. Hirsch, F. Grunebach, R. Repp, P. Brossart, W. Vogel, H.-G. Kopp, M. G. Manz, M. Bitzer, G. Schlimok, et al.
Rituximab consolidation after high-dose chemotherapy and autologous blood stem cell transplantation in follicular and mantle cell lymphoma: a prospective, multicenter phase II study
Ann. Onc.,
November 1, 2004;
15(11):
1691 - 1698.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kaufmann, M. Raderer, S. Wohrer, A. Puspok, A. Bankier, C. Zielinski, A. Chott, and J. Drach
Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma
Blood,
October 15, 2004;
104(8):
2269 - 2271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. G. Rajendran, D. R. Fisher, A. K. Gopal, L. D. Durack, O. W. Press, and J. F. Eary
High-Dose 131I-Tositumomab (Anti-CD20) Radioimmunotherapy for Non-Hodgkin's Lymphoma: Adjusting Radiation Absorbed Dose to Actual Organ Volumes
J. Nucl. Med.,
June 1, 2004;
45(6):
1059 - 1064.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Mangel, H. A. Leitch, J. M. Connors, R. Buckstein, K. Imrie, D. Spaner, M. Crump, N. Pennell, A. Boudreau, and N. L. Berinstein
Intensive chemotherapy and autologous stem-cell transplantation plus rituximab is superior to conventional chemotherapy for newly diagnosed advanced stage mantle-cell lymphoma: a matched pair analysis
Ann. Onc.,
February 1, 2004;
15(2):
283 - 290.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Gianni, M. Magni, M. Martelli, M. Di Nicola, C. Carlo-Stella, S. Pilotti, A. Rambaldi, S. Cortelazzo, C. Patti, G. Parvis, et al.
Long-term remission in mantle cell lymphoma following high-dose sequential chemotherapy and in vivo rituximab-purged stem cell autografting (R-HDS regimen)
Blood,
July 15, 2003;
102(2):
749 - 755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Branson, R. Chopra, P. D. Kottaridis, G. McQuaker, A. Parker, S. Schey, R. K. Chakraverty, C. Craddock, D. W. Milligan, R. Pettengell, et al.
Role of Nonmyeloablative Allogeneic Stem-Cell Transplantation After Failure of Autologous Transplantation in Patients With Lymphoproliferative Malignancies
J. Clin. Oncol.,
October 1, 2002;
20(19):
4022 - 4031.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. K. Gopal, J. G. Rajendran, S. H. Petersdorf, D. G. Maloney, J. F. Eary, B. L. Wood, T. A. Gooley, S. A. Bush, L. D. Durack, P. J. Martin, et al.
High-dose chemo-radioimmunotherapy with autologous stem cell support for relapsed mantle cell lymphoma
Blood,
May 1, 2002;
99(9):
3158 - 3162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. M. Howard, J. G. Gribben, D. S. Neuberg, M. Grossbard, C. Poor, M. J. Janicek, and M. A. Shipp
Rituximab and CHOP Induction Therapy for Newly Diagnosed Mantle-Cell Lymphoma: Molecular Complete Responses Are Not Predictive of Progression-Free Survival
J. Clin. Oncol.,
March 1, 2002;
20(5):
1288 - 1294.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. S. Andersen, J. K. Larsen, J. Christiansen, L. B. Pedersen, N. S. Christophersen, C. H. Geisler, and J. Jurlander
Soluble CD40 ligand induces selective proliferation of lymphoma cells in primary mantle cell lymphoma cell cultures
Blood,
September 15, 2000;
96(6):
2219 - 2225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. P. Schröder, B.-J. Kroesen, L. F. M. H. de Leij, and E. G. E. de Vries
Purging of Epithelial Tumor Cells from Peripheral Blood Stem Cells by Means of the Bispecific Antibody BIS-1
Clin. Cancer Res.,
June 1, 2000;
6(6):
2521 - 2527.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
Y. Yatabe, R. Suzuki, K. Tobinai, Y. Matsuno, R. Ichinohasama, M. Okamoto, M. Yamaguchi, J.-i. Tamaru, N. Uike, Y. Hashimoto, et al.
Significance of cyclin D1 overexpression for the diagnosis of mantle cell lymphoma: a clinicopathologic comparison of cyclin D1-positive MCL and cyclin D1-negative MCL-like B-cell lymphoma
Blood,
April 1, 2000;
95(7):
2253 - 2261.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Foran, A. Z. S. Rohatiner, D. Cunningham, R. A. Popescu, P. Solal-Celigny, M. Ghielmini, B. Coiffier, P. W. M. Johnson, C. Gisselbrecht, F. Reyes, et al.
European Phase II Study of Rituximab (Chimeric Anti-CD20 Monoclonal Antibody) for Patients With Newly Diagnosed Mantle-Cell Lymphoma and Previously Treated Mantle-Cell Lymphoma, Immunocytoma, and Small B-Cell Lymphocytic Lymphoma
J. Clin. Oncol.,
January 14, 2000;
18(2):
317 - 317.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
