Journal of Clinical Oncology, Vol 16, 139-144, Copyright © 1998 by American Society of Clinical Oncology
Interpreting the significance of changes in health-related quality-of- life scores
D Osoba, G Rodrigues, J Myles, B Zee and J Pater
British Columbia Cancer Agency and University of British Columbia, Vancouver, Canada. dosoba@bccancer.bc.ca
PURPOSE: To determine the significance to patients of changes in health-
related quality-of-life (HLQ) scores assessed by the European Organization
for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire
(QLQ-C30). PATIENTS AND METHODS: A subjective significance questionnaire
(SSQ), which asks patients about perceived changes in physical, emotional,
and social functioning and in global quality of life (global QL) and the
QLQ-C30 were completed by patients who received chemotherapy for either
breast cancer or small-cell lung cancer (SCLC). In the SSQ, patients rated
their perception of change since the last time they completed the QLQ-C30
using a 7-category scale that ranged from "much worse" through "no change"
to "much better." For each category of change in the SSQ, the corresponding
differences were calculated in QLQ-C30 mean scores and effect sizes were
determined. RESULTS: For patients who indicated "no change" in the SSQ, the
mean change in scores in the corresponding QLQ-C30 domains was not
significantly different from 0. For patients who indicated "a little"
change either for better or for worse, the mean change in scores was about
5 to 10; for "moderate" change, about 10 to 20; and for "very much" change,
greater than 20. Effect sizes increased in concordance with increasing
changes in SSQ ratings and QLQ-C30 scores. CONCLUSION: The significance of
changes in QLQ-C30 scores can be interpreted in terms of small, moderate,
or large changes in quality of life as reported by patients in the SSQ. The
magnitude of these changes also can be used to calculate the sample sizes
required to detect a specified change in clinical trials.
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F Boyer, J L Novella, S Bertaud, F Delmer, B Vesselle, and J C Etienne
Hereditary neuromuscular disease and multicomposite subjective health status: feasibility, internal consistency and test-retest reliability in the French version of the Nottingham Health Profile, the ISPN
Clinical Rehabilitation,
June 1, 2005;
19(6):
644 - 653.
[Abstract]
[PDF]
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K. J. Yost and D. T. Eton
Combining Distribution- and Anchor-Based Approaches to Determine Minimally Important Differences: The FACIT Experience
Eval Health Prof,
June 1, 2005;
28(2):
172 - 191.
[Abstract]
[PDF]
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B. Barrett, D. Brown, M. Mundt, and R. Brown
Sufficiently Important Difference: Expanding the Framework of Clinical Significance
Med Decis Making,
May 1, 2005;
25(3):
250 - 261.
[Abstract]
[PDF]
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