Journal of Clinical Oncology, Vol 16, 3550-3555, Copyright © 1998 by American Society of Clinical Oncology
Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with 18-fluoro-2-deoxyglucose positron emission tomography and comparison with computed tomography
CH Kao, SP ChangLai, PU Chieng, RF Yen and TC Yen
Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan, Republic of China. kao@vghtc.vghtc.gov.tw
PURPOSE: The effectiveness of positron emission tomography (PET) with 1
8-fluoro-2-deoxyglucose (FDG) for detecting suspected recurrence of
nasopharyngeal carcinomas (NPC) was evaluated and compared with computed
tomography (CT). PATIENTS AND METHODS: FDG-PET studies were performed on 36
NPC patients 4 months after radiotherapy. The images were interpreted
visually and quantitatively by calculating standardized uptake values
(SUVs). RESULTS: The sensitivity, specificity, and accuracy of visually
interpreted FDG-PET images, for differentiation of recurrent or persistent
NPC from benign lesions, were 100%, 96%, and 97%, respectively. Cases with
recurrent or persistent NPC (1.6 to 5.8) had significantly higher SUVs than
cases with benign lesions (0.8 to 1.5). The sensitivity, specificity, and
accuracy of CT for detecting recurrent or persistent NPC were 72%, 88%, and
83%, respectively. CONCLUSION: FDG-PET is a better tool than CT for the
detection of recurrent or persistent NPC. Either visual interpretation or
SUV can be used to differentiate benign lesions from recurrent or
persistent NPC.
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