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Journal of Clinical Oncology, Vol 18, Issue 2 (January), 2000: 307
© 2000 American Society for Clinical Oncology

Rapid Hematopoietic Recovery After Coinfusion of Autologous-Blood Stem Cells and Culture-Expanded Marrow Mesenchymal Stem Cells in Advanced Breast Cancer Patients Receiving High-Dose Chemotherapy

By Omer N. Koç, Stanton L. Gerson, Brenda W. Cooper, Stephanie M. Dyhouse, Stephen E. Haynesworth, Arnold I. Caplan, Hillard M. Lazarus

From the Departments of Medicine and Biology, Case Western Reserve University; and Division of Hematology/Oncology and Ireland Cancer Center of University Hospitals of Cleveland, Cleveland, OH.

Address reprint requests to Omer N. Koç, MD, Case Western Reserve University, BRB-3 Hematology/Oncology, 10900 Euclid Ave, Cleveland OH 44106; email onk2{at}po.cwru.edu

PURPOSE: Multipotential mesenchymal stem cells (MSCs) are found in human bone marrow and are shown to secrete hematopoietic cytokines and support hematopoietic progenitors in vitro. We hypothesized that infusion of autologous MSCs after myeloablative therapy would facilitate engraftment by hematopoietic stem cells, and we investigated the feasibility, safety, and hematopoietic effects of culture-expanded MSCs in breast cancer patients receiving autologous peripheral-blood progenitor-cell (PBPC) infusion.

PATIENTS AND METHODS: We developed an efficient method of isolating and culture-expanding a homogenous population of MSCs from a small marrow-aspirate sample obtained from 32 breast cancer patients. Twenty-eight patients were given high-dose chemotherapy and autologous PBPCs plus culture-expanded MSC infusion and daily granulocyte colony-stimulating factor.

RESULTS: Human MSCs were successfully isolated from a mean ± SD of 23.4 ± 5.9 mL of bone marrow aspirate from all patients. Expansion cultures generated greater than 1 x 106 MSCs/kg for all patients over 20 to 50 days with a mean potential of 5.6 to 36.3 x 106 MSCs/kg after two to six passages, respectively. Twenty-eight patients were infused with 1 to 2.2 x 106 expanded autologous MSCs/kg intravenously over 15 minutes. There were no toxicities related to the infusion of MSCs. Clonogenic MSCs were detected in venous blood up to 1 hour after infusion in 13 of 21 patients (62%). Median time to achieve a neutrophil count greater than 500/µL and platelet count >= 20,000/µL untransfused was 8 days (range, 6 to 11 days) and 8.5 days (range, 4 to 19 days), respectively.

CONCLUSION: This report is the first describing infusion of autologous MSCs with therapeutic intent. We found that autologous MSC infusion at the time of PBPC transplantation is feasible and safe. The observed rapid hematopoietic recovery suggests that MSC infusion after myeloablative therapy may have a positive impact on hematopoiesis and should be tested in randomized trials.




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