Advertisement
Journal of Clinical Oncology  
Search for:
Limit by:
  Browse by Subject or Issue
Home Search or Browse JCO My JCO Subscriptions Customer Service Site Map

Journal of Clinical Oncology, Vol 22, No 6 (March 15), 2004: pp. 1095-1102
© 2004 American Society of Clinical Oncology.
DOI: 10.1200/JCO.2004.07.131
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a colleague
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Save to my personal folders
Right arrow Download to citation manager
Right arrowRights & Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Devine, S. M.
Right arrow Articles by DiPersio, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Devine, S. M.
Right arrow Articles by DiPersio, J. F.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Rapid Mobilization of CD34+ Cells Following Administration of the CXCR4 Antagonist AMD3100 to Patients With Multiple Myeloma and Non-Hodgkin's Lymphoma

Steven M. Devine, Neal Flomenberg, David H. Vesole, Jane Liesveld, Daniel Weisdorf, Karin Badel, Gary Calandra, John F. DiPersio

From the Washington University School of Medicine, St Louis, MO; Thomas Jefferson University, Philadelphia, PA; Medical College of Wisconsin, Milwaukee, WI; University of Rochester, Rochester, NY; University of Minnesota, Minneapolis, MN; and AnorMed Inc, Langley, British Columbia, Canada.

Address reprint requests to Steven M. Devine, MD, 660 S Euclid Ave, Campus Box 8007, St Louis, MO 63110; e-mail: sdevine{at}im.wustl.edu

PURPOSE: Interactions between the chemokine receptor CXCR4 and its ligand stromal derived factor-1 regulate hematopoietic stem-cell trafficking. AMD3100 is a CXCR4 antagonist that induces rapid mobilization of CD34+ cells in healthy volunteers. We performed a phase I study assessing the safety and clinical effects of AMD3100 in patients with multiple myeloma (MM) and non-Hodgkin's lymphoma (NHL).

PATIENTS AND METHODS: Thirteen patients (MM, n = 7; NHL, n = 6) received AMD3100 at a dose of either 160 µg/kg (n = 6) or 240 µg/kg (n = 7). WBC and peripheral blood (PB) CD34+ cell counts were analyzed at 4 and 6 hours following injection.

RESULTS: AMD3100 caused a rapid and statistically significant increase in the total WBC and PB CD34+ counts at both 4 and 6 hours following a single injection. The absolute CD34+ cell count increased from a baseline of 2.6 ± 0.7/µL (mean ± SE) to 15.6 ± 3.9/µL and 16.2 ± 4.3/µL at 4 hours (P = .002) and 6 hours after injection (P = .003), respectively. The absolute CD34+ cell counts observed at 4 and 6 hours following AMD3100 were higher in the 240 µg/kg group (19.3 ± 6.9/µL and 20.4 ± 7.6/µL, respectively) compared with the 160 µg/kg group (11.3 ± 2.7/µL and 11.3 ± 2.5/µL, respectively). The drug was well tolerated and only grade 1 toxicities were encountered.

CONCLUSION: AMD3100 appears to be a safe and effective agent for the rapid mobilization of CD34+ cells in patients who have received prior chemotherapy. Further studies in combination with granulocyte colony-stimuating factor in patients with lymphoid malignancies are warranted.

Research support provided by Anormed, Inc, Langley, British Columbia.

Presented in part at the 8th Annual European Hematology Association Meeting, Lyon, France, June 14, 2003

Authors' disclosures of potential conflicts of interest are found at the end of this article.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 BloodHome page
Z. Zeng, Y. Xi Shi, I. J. Samudio, R.-Y. Wang, X. Ling, O. Frolova, M. Levis, J. B. Rubin, R. R. Negrin, E. H. Estey, et al.
Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML
Blood, June 11, 2009; 113(24): 6215 - 6224.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. Nervi, P. Ramirez, M. P. Rettig, G. L. Uy, M. S. Holt, J. K. Ritchey, J. L. Prior, D. Piwnica-Worms, G. Bridger, T. J. Ley, et al.
Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
Blood, June 11, 2009; 113(24): 6206 - 6214.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. F. DiPersio, E. A. Stadtmauer, A. Nademanee, I. N. M. Micallef, P. J. Stiff, J. L. Kaufman, R. T. Maziarz, C. Hosing, S. Fruehauf, M. Horwitz, et al.
Plerixafor and G-CSF versus placebo and G-CSF to mobilize hematopoietic stem cells for autologous stem cell transplantation in patients with multiple myeloma
Blood, June 4, 2009; 113(23): 5720 - 5726.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. K. Azab, J. M. Runnels, C. Pitsillides, A.-S. Moreau, F. Azab, X. Leleu, X. Jia, R. Wright, B. Ospina, A. L. Carlson, et al.
CXCR4 inhibitor AMD3100 disrupts the interaction of multiple myeloma cells with the bone marrow microenvironment and enhances their sensitivity to therapy
Blood, April 30, 2009; 113(18): 4341 - 4351.
[Abstract] [Full Text] [PDF]

Home page
 aacredbookHome page
M. A. Schroeder, M. P. Rettig, P. Ramirez, and J. F. DiPersio
Optimal Mobilization of Normal and Leukemic Stem Cells via Modulation of Chemokine and Integrin Axes
Am. Assoc. Cancer Res. Educ. Book, April 18, 2009; 2009(1): 15 - 22.
[Full Text] [PDF]

Home page
 BloodHome page
S. M. Devine, R. Vij, M. Rettig, L. Todt, K. McGlauchlen, N. Fisher, H. Devine, D. C. Link, G. Calandra, G. Bridger, et al.
Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction
Blood, August 15, 2008; 112(4): 990 - 998.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
M. J. Kucia, M. Wysoczynski, W. Wu, E. K. Zuba-Surma, J. Ratajczak, and M. Z. Ratajczak
Evidence That Very Small Embryonic-Like Stem Cells Are Mobilized into Peripheral Blood
Stem Cells, August 1, 2008; 26(8): 2083 - 2092.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Papayannopoulou and D. T. Scadden
Stem-cell ecology and stem cells in motion
Blood, April 15, 2008; 111(8): 3923 - 3930.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
R. M. Lemoli and A. D'Addio
Hematopoietic stem cell mobilization
Haematologica, March 1, 2008; 93(3): 321 - 324.
[Full Text] [PDF]

Home page
 BloodHome page
H. Kohara, Y. Omatsu, T. Sugiyama, M. Noda, N. Fujii, and T. Nagasawa
Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling
Blood, December 15, 2007; 110(13): 4153 - 4160.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
M Devetten and J. Armitage
Hematopoietic cell transplantation: progress and obstacles
Ann. Onc., September 1, 2007; 18(9): 1450 - 1456.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
M. Abraham, K. Biyder, M. Begin, H. Wald, I. D. Weiss, E. Galun, A. Nagler, and A. Peled
Enhanced Unique Pattern of Hematopoietic Cell Mobilization Induced by the CXCR4 Antagonist 4F-Benzoyl-TN14003
Stem Cells, September 1, 2007; 25(9): 2158 - 2166.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
I. Kryczek, S. Wei, E. Keller, R. Liu, and W. Zou
Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis
Am J Physiol Cell Physiol, March 1, 2007; 292(3): C987 - C995.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
L. Yang, E. Jackson, B. M. Woerner, A. Perry, D. Piwnica-Worms, and J. B. Rubin
Blocking CXCR4-Mediated Cyclic AMP Suppression Inhibits Brain Tumor Growth In vivo
Cancer Res., January 15, 2007; 67(2): 651 - 658.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. C. Spoo, M. Lubbert, W. G. Wierda, and J. A. Burger
CXCR4 is a prognostic marker in acute myelogenous leukemia
Blood, January 15, 2007; 109(2): 786 - 791.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
C. Carlo-Stella, M. Di Nicola, P. Longoni, L. Cleris, C. Lavazza, R. Milani, M. Milanesi, M. Magni, V. Pace, F. Colotta, et al.
Placental Growth Factor-1 Potentiates Hematopoietic Progenitor Cell Mobilization Induced by Granulocyte Colony-Stimulating Factor in Mice and Nonhuman Primates
Stem Cells, January 1, 2007; 25(1): 252 - 261.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
Z. Zeng, I. J. Samudio, M. Munsell, J. An, Z. Huang, E. Estey, M. Andreeff, and M. Konopleva
Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
Mol. Cancer Ther., December 1, 2006; 5(12): 3113 - 3121.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. M. Shepherd, B. J. Capoccia, S. M. Devine, J. DiPersio, K. M. Trinkaus, D. Ingram, and D. C. Link
Angiogenic cells can be rapidly mobilized and efficiently harvested from the blood following treatment with AMD3100
Blood, December 1, 2006; 108(12): 3662 - 3667.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
J. S. Hu, C. M. Freeman, V. R. Stolberg, B. C. Chiu, G. J. Bridger, S. P. Fricker, N. W. Lukacs, and S. W. Chensue
AMD3465, a Novel CXCR4 Receptor Antagonist, Abrogates Schistosomal Antigen-Elicited (Type-2) Pulmonary Granuloma Formation
Am. J. Pathol., August 1, 2006; 169(2): 424 - 432.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Condomines, P. Quittet, Z.-Y. Lu, L. Nadal, P. Latry, E. Lopez, M. Baudard, G. Requirand, C. Duperray, J.-F. Schved, et al.
Functional Regulatory T Cells Are Collected in Stem Cell Autografts by Mobilization with High-Dose Cyclophosphamide and Granulocyte Colony-Stimulating Factor.
J. Immunol., June 1, 2006; 176(11): 6631 - 6639.
[Abstract] [Full Text] [PDF]

Home page
 Occup Med (Lond)Home page
M. E. Berger, D. M. Christensen, P. C. Lowry, O. W. Jones, and A. L. Wiley
Medical management of radiation injuries: current approaches
Occup. Med., May 1, 2006; 56(3): 162 - 172.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Ottaiano, R. Franco, A. Aiello Talamanca, G. Liguori, F. Tatangelo, P. Delrio, G. Nasti, E. Barletta, G. Facchini, B. Daniele, et al.
Overexpression of Both CXC Chemokine Receptor 4 and Vascular Endothelial Growth Factor Proteins Predicts Early Distant Relapse in Stage II-III Colorectal Cancer Patients.
Clin. Cancer Res., May 1, 2006; 12(9): 2795 - 2803.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Larochelle, A. Krouse, M. Metzger, D. Orlic, R. E. Donahue, S. Fricker, G. Bridger, C. E. Dunbar, and P. Hematti
AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates
Blood, May 1, 2006; 107(9): 3772 - 3778.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Chen, A. Larochelle, S. Fricker, G. Bridger, C. E. Dunbar, and J. L. Abkowitz
Mobilization as a preparative regimen for hematopoietic stem cell transplantation
Blood, May 1, 2006; 107(9): 3764 - 3771.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Scala, P. Giuliano, P. A. Ascierto, C. Ierano, R. Franco, M. Napolitano, A. Ottaiano, M. L. Lombardi, M. Luongo, E. Simeone, et al.
Human Melanoma Metastases Express Functional CXCR4
Clin. Cancer Res., April 15, 2006; 12(8): 2427 - 2433.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Foudi, P. Jarrier, Y. Zhang, M. Wittner, J.-F. Geay, Y. Lecluse, T. Nagasawa, W. Vainchenker, and F. Louache
Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice
Blood, March 15, 2006; 107(6): 2243 - 2251.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. A. Burger and T. J. Kipps
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
Blood, March 1, 2006; 107(5): 1761 - 1767.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
K. Li, C. K. Y. Chuen, S. M. Lee, P. Law, T. F. Fok, P. C. Ng, C. K. Li, D. Wong, A. Merzouk, H. Salari, et al.
Small Peptide Analogue of SDF-1{alpha} Supports Survival of Cord Blood CD34+ Cells in Synergy with Other Cytokines and Enhances Their Ex Vivo Expansion and Engraftment into Nonobese Diabetic/Severe Combined Immunodeficient Mice
Stem Cells, January 1, 2006; 24(1): 55 - 64.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Burroughs, M. Mielcarek, M.-T. Little, G. Bridger, R. MacFarland, S. Fricker, J. Labrecque, B. M. Sandmaier, and R. Storb
Durable engraftment of AMD3100-mobilized autologous and allogeneic peripheral-blood mononuclear cells in a canine transplantation model
Blood, December 1, 2005; 106(12): 4002 - 4008.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Burger, T. Hartmann, M. Krome, J. Rawluk, H. Tamamura, N. Fujii, T. J. Kipps, and J. A. Burger
Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells
Blood, September 1, 2005; 106(5): 1824 - 1830.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
N. Flomenberg, S. M. Devine, J. F. DiPersio, J. L. Liesveld, J. M. McCarty, S. D. Rowley, D. H. Vesole, K. Badel, and G. Calandra
The use of AMD3100 plus G-CSF for autologous hematopoietic progenitor cell mobilization is superior to G-CSF alone
Blood, September 1, 2005; 106(5): 1867 - 1874.
[Abstract] [Full Text] [PDF]

Home page
 Stem CellsHome page
M. Kucia, R. Reca, K. Miekus, J. Wanzeck, W. Wojakowski, A. Janowska-Wieczorek, J. Ratajczak, and M. Z. Ratajczak
Trafficking of Normal Stem Cells and Metastasis of Cancer Stem Cells Involve Similar Mechanisms: Pivotal Role of the SDF-1-CXCR4 Axis
Stem Cells, August 1, 2005; 23(7): 879 - 894.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
G. Grignani, E. Perissinotto, G. Cavalloni, F. Carnevale Schianca, and M. Aglietta
Clinical Use of AMD3100 to Mobilize CD34+ Cells in Patients Affected by Non-Hodgkin's Lymphoma or Multiple Myeloma
J. Clin. Oncol., June 1, 2005; 23(16): 3871 - 3872.
[Full Text] [PDF]

Home page
 JCOHome page
S. Devine, Y. Gazitt, and G. Calandra
In Reply:
J. Clin. Oncol., June 1, 2005; 23(16): 3872 - 3873.
[Full Text] [PDF]

Home page
 JEMHome page
H. E. Broxmeyer, C. M. Orschell, D. W. Clapp, G. Hangoc, S. Cooper, P. A. Plett, W. C. Liles, X. Li, B. Graham-Evans, T. B. Campbell, et al.
Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist
J. Exp. Med., April 18, 2005; 201(8): 1307 - 1318.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. Noonan, W. Matsui, P. Serafini, R. Carbley, G. Tan, J. Khalili, M. Bonyhadi, H. Levitsky, K. Whartenby, and I. Borrello
Activated Marrow-Infiltrating Lymphocytes Effectively Target Plasma Cells and Their Clonogenic Precursors
Cancer Res., March 1, 2005; 65(5): 2026 - 2034.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
S. Scala, A. Ottaiano, P. A. Ascierto, M. Cavalli, E. Simeone, P. Giuliano, M. Napolitano, R. Franco, G. Botti, and G. Castello
Expression of CXCR4 Predicts Poor Prognosis in Patients with Malignant Melanoma
Clin. Cancer Res., March 1, 2005; 11(5): 1835 - 1841.
[Abstract] [Full Text] [PDF]


About
JCO		 Editorial
Roster		 Advertising
Information		 Librarians &
Institutions		 Rights &
Permissions		 PDA Services

Copyright © 2004 by the American Society of Clinical Oncology, Online ISSN: 1527-7755. Print ISSN: 0732-183X
Terms and Conditions of Use
  HighWire Press HighWire Press™ assists in the publication of JCO Online