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Resectable Brain Metastases

From the Cleveland Clinic Brain Tumor Institute; Departments of Neurosurgery and Radiation Oncology, Cleveland, OH

Address reprint requests to Michael A. Vogelbaum MD, PhD, Brain Tumor Institute/ND40, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH; e-mail: vogelbm{at}neus.ccf.org

Brain metastases are the most common brain tumors seen in clinical practice, comprising well over half of all brain tumors. For many years, surgical resection of brain metastases was considered a form of palliative therapy only, but more recently it has been shown to have a more important role in extending survival in appropriately selected patients. Newer surgical techniques have helped to reduce the morbidity associated with tumor resection. Although randomized studies have demonstrated the need for postoperative whole-brain radiotherapy, there remains interest in the use of other surgical adjuncts to delay or eliminate the need for fractionated radiotherapy. The use of various treatment modalities, particularly image-guided surgery and stereotactic radiosurgery, allows clinicians who are focused on the treatment of brain metastases to achieve superior levels of tumor control within the brain. As a result, overall survival is much more dependent on the status of the patient's systemic disease.

Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.

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