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© 2003 American Society for Clinical Oncology Thalidomide Alone or With Dexamethasone for Previously Untreated Multiple Myeloma
From the The University of Texas MD Anderson Cancer Center, Houston, TX. Address reprint requests to Donna Weber, MD, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 429, Houston, TX 77030, email: dmweber{at}mdanderson.org.
Purpose: To evaluate the activity of thalidomide in patients with asymptomatic multiple myeloma and of thalidomide-dexamethasone in patients with previously untreated symptomatic myeloma. Patients and Methods: Twenty-eight patients with previously untreated asymptomatic myeloma were treated with thalidomide 100 to 200 mg orally (PO) at bedtime (qhs) with serial increments of 50 to 100 mg at weekly intervals, as tolerated to a maximum of 600 mg PO qhs. Forty consecutive previously untreated patients with symptomatic myeloma were also treated as above (maximum dose 400 mg) and received dexamethasone 20 mg/m2 for 4 days beginning on days 1, 9, and 17; the second and third cycles of repeated dexamethasone were begun on day 30. Both groups of patients were treated for at least 3 months. Results: The response rate was 36% for patients treated with thalidomide alone and 72% for patients treated with thalidomide-dexamethasone, the latter including complete remission in 16% of patients. The median time to remission was 4.2 months with thalidomide alone and 0.7 months with thalidomide-dexamethasone. Grade 3 toxicity included infections (nine patients) and thrombotic/embolic events (seven patients). Five deaths have occurred as a result of multiple myeloma (two patients), infection (one patient), unknown cause (one patient), and a possible thromboembolic event (one patient). Conclusion: Thalidomide alone was effective in patients with newly diagnosed myeloma. The combination with dexamethasone induced a high frequency of response, rapid onset of remission, and low incidence of serious irreversible toxicity. These observations support further studies of this promising combination for patients with newly diagnosed multiple myeloma.
ALTHOUGH MANY treatments have been useful for patients with multiple myeloma, the disease eventually relapses and becomes resistant to treatment. Combinations of multiple alkylating agents with glucocorticoids or of vincristine-doxorubicin-dexamethasone (VAD) have not improved survival in comparison with melphalan-prednisone.1 Whereas treatments such as myeloablative therapy with autologous stem cell support have improved survival for many patients, other patients achieve limited or no gain because of early death, short remission, or persistent resistant disease.
Recently, Singhal et al2 described a 26% response rate for patients with resistant myeloma treated with thalidomide, as determined by Although the mechanism of action of thalidomide remains unclear and may be related to antiangiogenic or direct antitumor effects against myeloma, the drug is effective despite resistance to multiple standard therapies including alkylating agents, anthracycline, glucocorticoid combinations, and intensive therapy with stem cell support. Consequently, thalidomide may also be effective at diagnosis, possibly leading to improved response rate, particularly complete response (CR), and eventually impacting survival. We therefore initiated trials for previously untreated disease with thalidomide alone for asymptomatic patients, and in combination with repeated dexamethasone for symptomatic disease. Based on our prior experience in patients with resistant disease, we postulated that the combination of thalidomide-dexamethasone would induce rapid reduction of tumor mass, allowing prompt collection of autologous blood stem cells with granulocyte-colony-stimulating factor alone. Therefore, in eligible patients, treatment with thalidomide-dexamethasone was followed by intensive therapy with autologous stem cell support in an attempt to achieve maximum reduction of tumor burden.
Patients and Drug Regimens Between May 1999 and September 2001 we defined the role of thalidomide alone (provided by Celgene Corporation, Warren, NJ) in 28 consecutive patients with asymptomatic multiple myeloma. Only those patients at high risk for progression were eligible based on previously described combinations of risk factors (lytic bone lesion, IgA type, monoclonal protein  3.0 g/dL, Bence Jones protein [BJP] > 50 mg/d, or abnormal magnetic resonance imaging).8 High-risk disease was defined by lytic bone lesions or two risk factors, where the median time to progression was approximately 18 months. The initial dose of thalidomide was planned at 200 mg PO qhs, with serial increments of 50 to 200 mg at 1- to 2-week intervals in absence of serious toxicity, to a maximum of 600 mg PO qhs: two patients were started at 100 mg, two patients at 150 mg, and 24 patients at 200 mg. With moderate side effects, the thalidomide dose was reduced by 50- to 100-mg decrements until an acceptable level was reached and maintained. For severe toxicity, thalidomide was held and restarted using the aforementioned decrements after the side effect had improved. The median maximum dose achieved was 400 mg (one patient received a maximum dose of 150 mg, nine patients 200 mg, three patients 300 mg, 10 patients 400 mg, two patients 500 mg, and three patients 600 mg). Between July 2000 and July 2001, we also treated 40 consecutive, previously untreated patients with symptomatic multiple myeloma with thalidomide in a similar schedule, but with a maximum dose of 400 mg and combined with dexamethasone 20 mg/m2 for 4 days beginning on days 1, 9, and 17. Whereas the initial thalidomide dose was planned to be 100 mg, escalated weekly by 100 mg increments to 400 mg, 28 patients started at 100 mg, seven patients at 150 mg, and five patients at 200 mg. Only patients with low or intermediate tumor mass were eligible. Second cycles of repeated dexamethasone began on day 30, as did third cycles in 10 patients whose myeloma had improved but was not in remission. The median maximum dose of thalidomide received was 200 mg (three patients received a maximum dose of 150 mg, 18 patients received 200 mg, one patient 250 mg, 10 patients 300 mg, and eight patients 400 mg). Treatment with the combination was continued for at least 3 months (unless there was disease progression) until the earliest occurance of maximum plateau of myeloma protein reduction, autologous transplant-supported intensification, other treatments (VAD, PS-341) for resistant disease, or unacceptable toxicities (thrombotic events in two patients occurred prior to more effective prophylaxis with therapeutic doses of coumadin). For responding patients not in CR, and for those not proceeding to myeloablative therapy, thalidomide alone was continued in a maximum dose with tolerable side effects alone or with dexamethasone for 4 days each month. Patients in CR received at least 4 months of thalidomide-dexamethasone and then were observed without maintenance therapy. For both trials, more than 80% of patients received thalidomide in an average daily dose of 100 to 200 mg each evening during the initial 2 months of therapy.
The first 24 patients who received the combination were given coumadin 1 mg PO daily (qd) for prophylaxis of deep venous thrombosis (DVT). After it was clear that this was not preventive, therapeutic doses of prophylactic anticoagulation with coumadin or low– molecular weight heparin were given to the remaining 16 patients. These treatments were conducted after approval by our institutional review board and in accordance with an assurance filed with and approved by the Department of Health and Human Services. All patients provided written informed consent and were observed on the Celgene system for thalidomide education and prescribing safety (STEPS) program. Table 1
Staging and Clinical Response The diagnosis of multiple myeloma was based on standard criteria: all showed bone marrow plasmacytosis of more than 15% except for 16 patients who had biopsy-proven plasmacytomas and multiple lytic bone lesions, all patients showed a monoclonal globulin on serum or urine electrophoresis, and 28% of asymptomatic patients and 80% of symptomatic patients had lytic bone lesions. Plasma cell tumor mass was defined in each patient as high, intermediate, or low.9,10 High tumor mass was defined by either corrected serum calcium more than 11.5 mg/dL or hemoglobin less than 8.5 g/dL, and patients with such advanced disease were excluded. Low tumor mass required normal serum calcium, hemoglobin more than 10.5 g/dL, and serum myeloma protein less than 4.5 g/dL. All other patients were classified as intermediate tumor mass. Thus, as summarized in Table 1  , asymptomatic patients treated with thalidomide alone had less advanced disease than symptomatic patients given thalidomide-dexamethasone.
Partial response (PR) was defined as reductions by Using the same criteria, we evaluated our previous trials for similar groups of previously untreated patients for frequency and speed of myeloma response. This included 140 patients treated between June 1997 and May 2000 with dexamethasone alone (20 mg/m2 PO qd on days 1 to 4, 9 to 12, and 17 to 20 and repeated at 4 to 5 weeks with subsequent maintenance days 1 to 4, every 4 weeks), 170 patients treated between January 1992 and August 1997 with melphalan-dexamethasone (melphalan 8 mg/m2/d PO for 4 days and same regimen of dexamethasone every 5 weeks), and 128 patients treated between December 1984 and October 1993 with VAD (vincristine 0.4 mg/d and doxorubicin 9 mg/m2/d by continuous infusion IV over 24 hours for 4 days with dexamethasone as above repeated every 4 to 5 weeks).12,13,14
Frequency of Remission Disease remission was noted in 10 patients (36%) treated with thalidomide alone and in 29 patients (72%) treated with thalidomide-dexamethasone. Five patients treated with the combination achieved CR (16%) based on disappearance of serum myeloma protein and, if present, urine paraprotein by immunofixation; two of nine additional patients with only Bence Jones protein had complete disappearance by urine immunofixation. Two patients achieved CR by immunofixation, but follow-up marrow was not available at the time of this report. Five patients included as PRs had reductions of serum paraprotein by 75% (median pretreatment serum level of 3.6 g/dL, median posttreatment value of 0.8 g/dL) but did not achieve 75% reduction of minimal BJP (< 200 mg/d; median pretreatment BJP 0.021 g/d, median posttreatment BJP 0.012 g/d). All responding patients showed relief of bone pain, correction of anemia when present, and in 25 patients with posttreatment marrow available, reduction of marrow plasmacytosis to less than 10%. Two responding patients required vertebroplasty for relief of persistent back pain. The median time to remission for patients responsive to thalidomide alone was 4.2 months, in contrast to 0.7 months for those who received thalidomide-dexamethasone. For patients responsive to combination therapy, 86% of patients were in remission within 2 months; the median time to complete remission was 2.3 months (range, 1.6 to 2.9 months). No clinical or laboratory features, including ß2-microglobulin and paraprotein level, correlated with response. At a median follow-up of 25 and 9 months, respectively, relapse had occurred in three patients on thalidomide alone after 4, 12, and 21 months, and in one patient on the combination, so it is premature to assess remission duration and survival.
Autologous Blood Stem Cells
Toxicity
Thalidomide produced remissions in 36% of patients with previously untreated asymptomatic multiple myeloma, similar to the frequency observed in patients with resistant disease.2,3 This effect was similar to that of other single agents, such as melphalan and high-dose dexamethasone, supporting the potential for more frequent control with combinations of these drugs that act by different mechanisms. Furthermore, our results with thalidomide as a single agent were nearly identical to those reported by Rajkumar et al,15 who observed six responses in 16 similar patients (38%) using doses ranging from 200 to 800 mg/d. Among previously untreated patients with more advanced and symptomatic disease, the combination of thalidomide-dexamethasone doubled the response rate and induced remissions more rapidly, indicating that the combination of both drugs was superior to either alone. This experience conforms well with the superiority of the same combination among patients with resistant disease, even those who had been resistant to sequential trials of dexamethasone and thalidomide separately.4,5 Our results with this combination were also similar to the response rate of 64% observed by Rajkumar et al16 in 50 comparable, newly diagnosed patients. Given the 25% incidence of thrombotic/embolic events in the first 24 patients treated with thalidomide-dexamethasone and warfarin 1 mg PO qd, and the absence of thrombotic events in the subsequent 16 patients given therapeutic doses of warfarin, further characterization of coagulation factors at baseline and during treatment and the preventive role of therapeutic anticoagulation in high-risk patients should be addressed. Whereas most other side effects were mild and reversible with dose reduction or temporary cessation of thalidomide, neuropathy was rarely irreversible. These uncommon side effects should not detract from the higher response rate of thalidomide-dexamethasone with little or no serious toxicity in the majority of patients. The newer immunomodulatory derivatives (IMiDs) of thalidomide, which seem more potent in vitro, may avoid or reduce serious side effects such as neuropathy while retaining significant antitumor effects.17,18 The potential value of thalidomide alone as prophylactic therapy for asymptomatic myeloma remains unclear. While the time to disease progression may be prolonged for those with responsive disease, premature and long-term therapy in asymptomatic patients may contribute to later drug resistance when the more effective thalidomide-dexamethasone combination may be necessary for disease progression. In some asymptomatic patients who experience neuropathy, prolonged therapy with thalidomide may also prevent future use of this and other potentially neuropathic drugs (thalidomide, vincristine, PS-341) when the disease becomes symptomatic. Randomized controlled studies that include data on later sensitivity to induction therapy for symptomatic disease, remission time, and late side effects are required to clarify these questions. The mechanism of myeloma control with thalidomide remains unclear. Thalidomide inhibits angiogenesis in vitro, induces apoptosis, and reduces the high levels of certain angiogenesis factors, such as VEGF and bFGF, that are present in patients with multiple myeloma and other hematologic malignancies.19–21 However, no correlation between marrow vascularization and clinical response of myeloma has been noted.2 Recently, a direct effect inducing G1 growth arrest and subsequent apoptosis, perhaps through interleukin-6 downregulation, has been demonstrated in vitro.21
Regardless of the mechanism, thalidomide-dexamethasone provided a simple, relatively safe, and remarkably effective primary treatment for nearly three-fourths of patients with previously untreated symptomatic multiple myeloma. Results seemed superior to previous experiences in comparable patients with dexamethasone alone, or in combination with melphalan, and similar to those with VAD, but with fewer complications (Table 3
Since the complete remission rate remained low, this program of induction therapy should be followed by intensive consolidation therapy in most eligible patients to achieve complete remission that translates into longer survival.22 Because serious irreversible toxicity was rare and myelosuppression virtually nonexistent, patients with responsive disease proceeded early to stem cell collection with granulocyte colony-stimulating factor alone, followed by high-dose melphalan therapy with stem cell support. Considering the ease of oral administration, the infrequency of serious irreversible side effects, and the rapidity of response permitting early stem cell collection, the combination of thalidomide-dexamethasone may well represent the treatment of choice for myeloma patients with disease of low or intermediate tumor mass.
We thank Rose Guevara for secretarial support.
Supported by the myeloma research funds established by Hill and Knowlton (in honor of William Max Watson) and Kay Laro. Thalidomide provided by Celgene Corporation, Warren, NJ.
1. Myeloma Trialists Collaborative Group: Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: An overview of 6,633 patients from 27 randomized trials. J Clin Oncol 16:3832–3842, 1998
2. Singhal S, Mehta J, Desikan R, et al: Antitumor activity of thalidomide in refractory multiple myeloma. N Engl J Med 341:1565–1571, 1999 3. Alexanian R, Weber D: Thalidomide for resistant and relapsing myeloma. Semin Hematol 37:22–25, 2000[Medline] 4. Weber DM, Rankin K, Delasalle K, et al: Thalidomide alone and in combination for previously untreated multiple myeloma. VIII International Myeloma Workshop, Banff, Canada 109:2001 (abstract S66) 5. Rajkumar SV: Angiogenesis and anti-angiogenic therapy with thalidomide for myeloma, Banff, Canada. VIII International Myeloma Workshop, p112, 2001 (abstract S68) 6. Durie BGM, Stepan DE: Efficacy of low dose thalidomide in multiple myeloma. Blood 94:316a, 1999 (abstract)
7. Dimopoulos MA, Zervas K, Kouvatseas G, et al: Thalidomide and dexamethasone combination for refractory myeloma. Ann Oncol 12:991–995, 2001 8. Weber DM, Dimopoulos M, Moulopoulos LA, et al: Prognostic features of asymptomatic multiple myeloma. Br J Haematol 97:810–814, 1997[Medline] 9. Durie B, Salmon S: A clinical staging system for multiple myeloma. Cancer 36:842–847, 1975[CrossRef][Medline] 10. Alexanian R, Balcerzak S, Bonnet J, et al: Prognostic factors in multiple myeloma. Cancer 36:1192–1201, 1975[CrossRef][Medline]
11. McLaughlin P, Alexanian R: Myeloma protein kinetics following chemotherapy. Blood 60:851–855, 1982 12. Alexanian R, Barlogie B, Tucker S: VAD-based regimens as primary treatment for multiple myeloma. Am J Hematol 33:86, 1990[Medline]
13. Alexanian R, Weber D, Dimopoulos M, et al: Randomized trial of
14. Alexanian R, Dimopoulos M, Delasalle K, et al: Primary dexamethasone treatment of multiple myeloma. Blood 80:887–890, 1992 15. Rajkumar S, Dispenzieri A, Fonseca R, et al: Thalidomide for previously untreated indolent or smoldering multiple myeloma. Leukemia 15:1274–1276, 2001[CrossRef][Medline] 16. Rajkumar V, Hayman S, Gertz M, et al: Combination therapy with thalidomide plus dexamethasone for newly diagnosed multiple myeloma. Blood 98:849a, 2001 (abstract) 17. Richardson P, Schlossman R, Hideshima T, et al: A phase I study of oral CC5013, an immunomodulatory thalidomide derivative in patients with relapsed and refractory multiple myeloma. Blood 98:775a, 2001 (abstract) 18. Zangari M, Tricot G, Zeldis J, et al: Results of phase I study of CC5013 for the treatment of multiple myeloma patients who relapse after high dose chemotherapy. Blood 98:775a, 2001 (abstract)
19. D’Amato RJ, Loughnan MS, Flynn E, et al: Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci 91:4082–4085, 1994 20. Kenyon BM, Brown F, D’Amato RJ: Effects of thalidomide and metabolites in a mouse corneal model of neovascularization. Exp Eye Res 64:971–978, 1997[CrossRef][Medline]
21. Hideshima T, Chauhan D, Shima Y, et al: Thalidomide and its analogs overcome drug resistance to human multiple myeloma cells to conventional therapy. Blood 96:2943–2950, 2000 22. Alexanian R, Weber D, Giralt S, et al: Impact of complete remission with intensive therapy in patients with responsive multiple myeloma. Bone Marrow Transplant 27:1037–1043, 2001.[CrossRef][Medline] Submitted March 27, 2002; accepted September 6, 2002. This article has been cited by other articles:
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ABSTRACT
INTRODUCTION
-interferon or dexamethasone as maintenance treatment for multiple myeloma. Am J Hematol 65:204–209, 2000
