IN MEMORIAM

C. GORDON ZUBROD, MD

Emil Frei III

JCO May 1 1999: 1331. [Full Text] [PDF]

EDITORIALS

Concurrent Chemotherapy and Radiation: A Major Advance for Women With Cervical Cancer

Patricia J. Eifel

JCO May 1 1999: 1334. [Full Text] [PDF]

The Tea Leaves of Small Trials

David P. Harrington

JCO May 1 1999: 1336. [Full Text] [PDF]

RAPID PUBLICATIONS
	Randomized Comparison of Fluorouracil Plus Cisplatin Versus Hydroxyurea as an Adjunct to Radiation Therapy in Stage IIB-IVA Carcinoma of the Cervix With Negative Para-Aortic Lymph Nodes: A Gynecologic Oncology Group and Southwest Oncology Group Study
	Charles W. Whitney, William Sause, Brian N. Bundy, John H. Malfetano, Edward V. Hannigan, Wesley C. Fowler, Jr, Daniel L. Clarke-Pearson, and Shu-Yuan Liao
	JCO May 1 1999: 1339g. [Abstract] [Full Text] [PDF]

GASTROINTESTINAL CANCER
	Comparative Efficacy of Adjuvant Chemotherapy in Patients With Dukes' B Versus Dukes' C Colon Cancer: Results From Four National Surgical Adjuvant Breast and Bowel Project Adjuvant Studies (C-01, C-02, C-03, and C-04)
	Eleftherios Mamounas, Samuel Wieand, Norman Wolmark, Harry D. Bear, James N. Atkins, Kyunghee Song, Judy Jones, and Howard Rockette
	JCO May 1 1999: 1349. [Abstract] [Full Text] [PDF]
	Efficacy of Adjuvant Fluorouracil and Folinic Acid in B2 Colon Cancer
	JCO May 1 1999: 1356. [Abstract] [Full Text] [PDF]
	Analysis of the p53/BAX Pathway in Colorectal Cancer: Low BAX Is a Negative Prognostic Factor in Patients With Resected Liver Metastases
	Isrid Sturm, Claus-Henning Köhne, Gerhard Wolff, Henrik Petrowsky, Timo Hillebrand, Steffen Hauptmann, Matthias Lorenz, Bernd Dörken, and Peter T. Daniel
	JCO May 1 1999: 1364. [Abstract] [Full Text] [PDF]
	p53 and K-ras Gene Mutations Correlate With Tumor Aggressiveness But Are Not of Routine Prognostic Value in Colorectal Cancer
	Silvia Tortola, Eugenio Marcuello, Isabel González, Germán Reyes, Rosa Arribas, Gemma Aiza, Francesc J. Sancho, Miguel A. Peinado, and Gabriel Capella
	JCO May 1 1999: 1375. [Abstract] [Full Text] [PDF]

GYNECOLOGIC CANCER
	Prognostic Significance of Angiogenesis and Ki-67, p53, and p21 Expression: A Population-Based Endometrial Carcinoma Study
	Helga B. Salvesen, Ole Erik Iversen, and Lars A. Akslen
	JCO May 1 1999: 1382. [Abstract] [Full Text] [PDF]
	Detection of Human Papillomavirus Types 16 and 18 mRNA in Peripheral Blood of Advanced Cervical Cancer Patients and Its Association With Prognosis
	Chih-Jen Tseng, Chia C. Pao, Jen-Daw Lin, Yung-Kuei Soong, Ji-Hong Hong, and Swei Hsueh
	JCO May 1 1999: 1391. [Abstract] [Full Text] [PDF]

BREAST CANCER
	Safety and Efficacy of Using a Single Agent or a Phase II Agent Before Instituting Standard Combination Chemotherapy in Previously Untreated Metastatic Breast Cancer Patients: Report of a Randomized Study—Cancer and Leukemia Group B 8642
	Mary E. Costanza, Raymond B. Weiss, I. Craig Henderson, Larry Norton, Donald A. Berry, Constance Cirrincione, Eric Winer, William C. Wood, Emil Frei III, O. Ross McIntyre, and Richard L. Schilsky
	JCO May 1 1999: 1397. [Abstract] [Full Text] [PDF]
	Infusional Paclitaxel and Weekly Vinorelbine Chemotherapy With Concurrent Filgrastim for Metastatic Breast Cancer: High Complete Response Rate in a Phase I-II Study of Doxorubicin-Treated Patients
	Georgiana K. Ellis, Julie R. Gralow, H. Irving Pierce, Margaret A. Williams, and R. B. Livingston
	JCO May 1 1999: 1407. [Abstract] [Full Text] [PDF]
	Prospective Randomized Trial of Docetaxel Versus Mitomycin Plus Vinblastine in Patients With Metastatic Breast Cancer Progressing Despite Previous Anthracycline-Containing Chemotherapy
	J.-M. Nabholtz, H. J. Senn, W. R. Bezwoda, D. Melnychuk, L. Deschênes, J. Douma, T. A. Vandenberg, B. Rapoport, R. Rosso, V. Trillet-Lenoir, J. Drbal, A. Molino, J.W.R. Nortier, D. J. Richel, T. Nagykalnai, P. Siedlecki, N. Wilking, J. Y. Genot, P.S.G.J. Hupperets, F. Pannuti, D. Skarlos, E. M. Tomiak, M. Murawsky, M. Alakl, A. Riva, and M. Aapro
	JCO May 1 1999: 1413. [Abstract] [Full Text] [PDF]
	Phase II Trial of Liposome-Encapsulated Doxorubicin, Cyclophosphamide, and Fluorouracil as First-Line Therapy in Patients With Metastatic Breast Cancer
	Vicente Valero, Aman U. Buzdar, Richard L. Theriault, Nozar Azarnia, Gustavo A. Fonseca, Jie Willey, Michael Ewer, Ronald S. Walters, Bruce Mackay, Donald Podoloff, Daniel Booser, Lily W. Lee, and Gabriel N. Hortobagyi
	JCO May 1 1999: 1425. [Abstract] [Full Text] [PDF]
	Phase II Trial of High-Dose Liposome-Encapsulated Doxorubicin With Granulocyte Colony-Stimulating Factor in Metastatic Breast Cancer
	C. L. Shapiro, T. Ervin, L. Welles, N. Azarnia, J. Keating, and Daniel F. Hayes
	JCO Apr 1 1999: 1435. [Abstract] [Full Text] [PDF]
	Tumor Characteristics and Clinical Outcome of Tubular and Mucinous Breast Carcinomas
	Sami G. Diab, Gary M. Clark, C. Kent Osborne, Arlene Libby, D. Craig Allred, and Richard M. Elledge
	JCO May 1 1999: 1442. [Abstract] [Full Text] [PDF]
	Breast-Conserving Therapy: Proteases as Risk Factors in Relation to Survival After Local Relapse
	Marion E. Meijer-van Gelder, Maxime P. Look, Joan Bolt-de Vries, Harry A. Peters, Jan G.M. Klijn, and John A. Foekens
	JCO May 1 1999: 1449. [Abstract] [Full Text] [PDF]
	Time Trends in Systemic Adjuvant Treatment for Node-Negative Breast Cancer
	Nicole Hébert-Croteau, Jacques Brisson, Jean Latreille, Gilles Gariépy, Caty Blanchette, and Luc Deschênes
	JCO May 1 1999: 1458. [Abstract] [Full Text] [PDF]
	Is Axillary Lymph Node Dissection Indicated for Early-Stage Breast Cancer? A Decision Analysis
	Giovanni Parmigiani, Donald A. Berry, Eric P. Winer, Claudia Tebaldi, J. Dirk Iglehart, and Leonard R. Prosnitz
	JCO May 1 1999: 1465. [Abstract] [Full Text] [PDF]
	Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand-Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer
	Jennet M. Harvey, Gary M. Clark, C. Kent Osborne, and D. Craig Allred
	JCO May 1 1999: 1474. [Abstract] [Full Text] [PDF]
	Estrogen Replacement Therapy After Localized Breast Cancer: Clinical Outcome of 319 Women Followed Prospectively
	Rena Vassilopoulou-Sellin, Lina Asmar, Gabriel N. Hortobagyi, Mary Jean Klein, Marsha McNeese, Sonja E. Singletary, and Richard L. Theriault
	JCO May 1 1999: 1482. [Abstract] [Full Text] [PDF]
	Effect of Tamoxifen on Sexual Functioning in Patients With Breast Cancer
	Joanne E. Mortimer, Leslie Boucher, Jack Baty, Diana L. Knapp, Elizabeth Ryan, and Julia H. Rowland
	JCO May 1 1999: 1488. [Abstract] [Full Text] [PDF]

GENITOURINARY CANCER
	Testicular Function After Cytotoxic Chemotherapy: Evidence of Leydig Cell Insufficiency
	S. J. Howell, J. A. Radford, W.D.J. Ryder, and S. M. Shalet
	JCO May 1 1999: 1493. [Abstract] [Full Text] [PDF]
	Postoperative Nomogram for Disease Recurrence After Radical Prostatectomy for Prostate Cancer
	Michael W. Kattan, Thomas M. Wheeler, and Peter T. Scardino
	JCO May 1 1999: 1499. [Abstract] [Full Text] [PDF]

MELANOMA
	Prospective Study of Fluorodeoxyglucose–Positron Emission Tomography Imaging of Lymph Node Basins in Melanoma Patients Undergoing Sentinel Node Biopsy
	Jeffrey D. Wagner, Donald Schauwecker, Darrell Davidson, John J. Coleman III, Scott Saxman, Gary Hutchins, Charlene Love, and John T. Hayes
	JCO May 1 1999: 1508. [Abstract] [Full Text] [PDF]

BRAIN TUMORS
	Irinotecan Therapy in Adults With Recurrent or Progressive Malignant Glioma
	Henry S. Friedman, William P. Petros, Allan H. Friedman, Larry J. Schaaf, Tracy Kerby, Jennifer Lawyer, Mary Parry, Peter J. Houghton, Shelley Lovell, Karima Rasheed, Tim Cloughsey, Elizabeth S. Stewart, O. Michael Colvin, James M. Provenzale, Roger E. McLendon, Darell D. Bigner, Ilkcan Cokgor, Michael Haglund, Jeremy Rich, David Ashley, Joseph Malczyn, Gary L. Elfring, and Langdon L. Miller
	JCO May 1 1999: 1516. [Abstract] [Full Text] [PDF]

LUNG CANCER
	Cisplatin, Gemcitabine, and Vinorelbine Combination Therapy in Advanced Non–Small-Cell Lung Cancer: A Phase II Randomized Study of the Southern Italy Cooperative Oncology Group
	Pasquale Comella, Giuseppe Frasci, Nicola Panza, Luigi Manzione, Vito Lorusso, Gaetano Di Rienzo, Riccardo Cioffi, Giuseppe De Cataldis, Luigi Maiorino, Domenico Bilancia, Gianpaolo Nicolella, Michele Natale, Franco Carpagnano, Carmen Pacilio, Mario De Lena, Andrea Bianco, and Giuseppe Comella
	JCO May 1 1999: 1526. [Abstract] [Full Text] [PDF]

BONE MARROW TRANSPLANTATION
	Expression of MUC-1 Epitopes on Normal Bone Marrow: Implications for the Detection of Micrometastatic Tumor Cells
	Wolfram Brugger, Hans-Jörg Bühring, Frank Grünebach, Wichard Vogel, Sepp Kaul, Robert Müller, Tim H. Brümmendorf, Benedikt L. Ziegler, Irene Rappold, Peter Brossart, Stefan Scheding, and Lothar Kanz
	JCO May 1 1999: 1535. [Abstract] [Full Text] [PDF]
	Improved Outcome With T-Cell–Depleted Bone Marrow Transplantation for Acute Leukemia
	Franco Aversa, Adelmo Terenzi, Alessandra Carotti, Rita Felicini, Roberta Jacucci, Tiziana Zei, Paolo Latini, Cynthia Aristei, Antonella Santucci, Maria Paola Martelli, Isabel Cunningham, Yair Reisner, and Massimo F. Martelli
	JCO May 1 1999: 1545. [Abstract] [Full Text] [PDF]
	Plasmablastic Morphology Is an Independent Predictor of Poor Survival After Autologous Stem-Cell Transplantation for Multiple Myeloma
	S. Vincent Rajkumar, Rafael Fonseca, Martha Q. Lacy, Thomas E. Witzig, Terry M. Therneau, Robert A. Kyle, Mark R. Litzow, Morie A. Gertz, and Philip R. Greipp
	JCO May 1 1999: 1551. [Abstract] [Full Text] [PDF]

HEMATOLOGIC MALIGNANCIES
	Small Noncleaved, Non-Burkitt's (Burkitt-Like) Lymphoma: Cytogenetics Predict Outcome and Reflect Clinical Presentation
	Nicol Macpherson, David Lesack, Richard Klasa, Doug Horsman, Joseph M. Connors, Michael Barnett, and Randy D. Gascoyne
	JCO May 1 1999: 1558. [Abstract] [Full Text] [PDF]

PEDIATRIC ONCOLOGY
	Cerebrospinal Fluid Asparagine Concentrations After Escherichia coli Asparaginase in Children With Acute Lymphoblastic Leukemia
	Michael H. Woo, Lawrence J. Hak, Michael C. Storm, Amar J. Gajjar, John T. Sandlund, Patricia L. Harrison, Bo Wang, Ching-Hon Pui, and Mary V. Relling
	JCO May 1 1999: 1568. [Abstract] [Full Text] [PDF]

PHASE I AND CLINICAL PHARMACOLOGY
	Pharmacokinetic Study of Single Doses of Oral Fludarabine Phosphate in Patients With "Low-Grade" Non-Hodgkin's Lymphoma and B-Cell Chronic Lymphocytic Leukemia
	James M. Foran, David Oscier, Jennifer Orchard, Stephen A. Johnson, Mary Tighe, Michael H. Cullen, Philippa G. de Takats, Christian Kraus, Marcus Klein, and T. Andrew Lister
	JCO May 1 1999: 1574. [Abstract] [Full Text] [PDF]
	Tumor, Normal Tissue, and Plasma Pharmacokinetic Studies of Fluorouracil Biomodulation With N-Phosphonacetyl-L-aspartate, Folinic Acid, and Interferon Alfa
	Robert J.A. Harte, Julian C. Matthews, Susan M. O'Reilly, D.W. Owen Tilsley, Safiye Osman, Gavin Brown, Sajinder J. Luthra, Frank Brady, Terry Jones, and Patricia M. Price
	JCO May 1 1999: 1580. [Abstract] [Full Text] [PDF]
	High-Dose Leucovorin as Sole Therapy for Methotrexate Toxicity
	Carlos D. Flombaum and Paul A. Meyers
	JCO May 1 1999: 1589. [Abstract] [Full Text] [PDF]
	Impact of Therapeutic Research on Informed Consent and the Ethics of Clinical Trials: A Medical Oncology Perspective
	Christopher K. Daugherty
	JCO May 1 1999: 1601. [Abstract] [Full Text] [PDF]

SUPPORTIVE CARE AND QUALITY OF LIFE
	Moral Concerns of Different Types of Patients in Clinical BRCA1/2 Gene Mutation Testing
	Guido Goelen, Adelheid Rigo, Maryse Bonduelle, and Jacques De Grève
	JCO May 1 1999: 1595. [Abstract] [Full Text] [PDF]

BIOLOGY OF NEOPLASIA
	Role of FHIT in Human Cancer
	Carlo M. Croce, Gabriella Sozzi, and Kay Huebner
	JCO May 1 1999: 1618. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Review of the Efficacy of Individualized Chemotherapy Selected by In Vitro Drug Sensitivity Testing for Patients With Cancer
	Patricia Cortazar and Bruce E. Johnson
	JCO May 1 1999: 1625. [Abstract] [Full Text] [PDF]

SPECIAL ARTICLES

National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial: A Reflective Commentary

Bernard Fisher

JCO May 1 1999: 1632. [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Uncommon Sites of Presentation of Hematologic Malignancies

Abhinav Chandra and David Eilender

JCO May 1 1999: 1640. [Full Text] [PDF]

Uncommon Sites of Presentation of Hematologic Malignancies

Christian Taverna, Peter Vogt, and Bernhard C. Pestalozzi

JCO May 1 1999: 1640a. [Full Text] [PDF]

CORRESPONDENCE
	Quality of Life in Advanced Colorectal Cancer
	Thierry Conroy and Francis Guillemin
	JCO May 1 1999: 1644a. [Full Text] [PDF]
	Misleading Title and Abstract in Recent Granulocyte-Macrophage Colony-Stimulating Factor Trial
	Joel S. Grossman, Joan Kroener, Alain Ravaud, and Binh Nguyen Bui
	JCO May 1 1999: 1644b. [Full Text] [PDF]
	Prostate-Specific Antigen Doubling Time: A Potential Surrogate End Point in Hormone-Refractory Prostate Cancer
	Hans-Peter Schmid, Axel Semjonow, Rudolf Maibach, and Nancy A. Dawson
	JCO May 1 1999: 1644c. [Full Text] [PDF]
	Meta-Analyses of Published Results Are Unreliable
	Marc Buyse, Robert W. Carlson, Pascal Piedbois, R. Fossati, C. Confalonieri, V. Torri, and A. Liberati
	JCO May 1 1999: 1644d. [Full Text] [PDF]
	Use of Placebos in Delayed-Emesis Studies
	Rudolph M. Navari and Paul J. Hesketh
	JCO May 1 1999: 1644f. [Full Text] [PDF]
	Immunohistochemical Assays for HER2 Overexpression
	Diane M. Maia
	JCO May 1 1999: 1644g. [Full Text] [PDF]
	Cardiotoxicity Associated With Paclitaxel/Trastuzumab Combination Therapy
	Susan Jerian, Patricia Keegan, and Edith A. Perez
	JCO May 1 1999: e1644. [Full Text] [PDF]

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