EDITORIALS

The Policing of Clinical Trials

George P. Canellos

JCO Jun 12 2000: 2353. [Full Text] [PDF]

LUNG CANCER
	Randomized Phase III Trial of Docetaxel Versus Vinorelbine or Ifosfamide in Patients With Advanced Non–Small-Cell Lung Cancer Previously Treated With Platinum-Containing Chemotherapy Regimens
	Frank V. Fossella, Russell DeVore, Ronald N. Kerr, Jeffrey Crawford, Ronald R. Natale, Frank Dunphy, Leonard Kalman, Vincent Miller, Jin Soo Lee, Melvin Moore, David Gandara, Daniel Karp, Everett Vokes, Mark Kris, Yong Kim, Francis Gamza, and Luz Hammershaimb
	JCO Jun 12 2000: 2354–2362. [Abstract] [Full Text] [PDF]

BREAST CANCER
	Phase I/II Trial of Cyclophosphamide, Mitoxantrone, and Escalated Doses of Carboplatin Supported by Peripheral-Blood Stem Cells in Women With Metastatic Breast Cancer
	Amita Patnaik, Janet MacKinnon, Paul Goss, Tracy Nagy, Keith Stewart, Armand Keating, and Michael Crump
	JCO Jun 12 2000: 2363–2368. [Abstract] [Full Text] [PDF]
	Phase II Trial of Doxorubicin and Docetaxel Plus Granulocyte Colony-Stimulating Factor in Metastatic Breast Cancer: Eastern Cooperative Oncology Group Study E1196
	Joseph A. Sparano, Anne O’Neill, Paul L. Schaefer, Carla I. Falkson, and William C. Wood
	JCO Jun 12 2000: 2369–2377. [Abstract] [Full Text] [PDF]
	Low-Dose Oral Fluorouracil With Eniluracil as First-Line Chemotherapy Against Advanced Breast Cancer: A Phase II Study
	Ian E. Smith, Stephen R. D. Johnston, Mary E. R. O’Brien, Tamas F. Hickish, Richard H. de Boer, Alison Norton, Deborah T. Cirkel, and Claire M. Barton
	JCO Jun 12 2000: 2378–2384. [Abstract] [Full Text] [PDF]
	Phase III Comparative Study of Vinorelbine Combined With Doxorubicin Versus Doxorubicin Alone in Disseminated Metastatic/Recurrent Breast Cancer: National Cancer Institute of Canada Clinical Trials Group Study MA8
	B. Norris, K. I. Pritchard, K. James, J. Myles, K. Bennett, S. Marlin, J. Skillings, B. Findlay, T. Vandenberg, P. Goss, J. Latreille, L. Rudinskas, W. Lofters, M. Trudeau, D. Osoba, and A. Rodgers
	JCO Jun 12 2000: 2385–2394. [Abstract] [Full Text] [PDF]
	Palliative Effect of Chemotherapy: Objective Tumor Response Is Associated With Symptom Improvement in Patients With Metastatic Breast Cancer
	Paul Geels, Elizabeth Eisenhauer, Andrea Bezjak, Benny Zee, and Andrew Day
	JCO Jun 12 2000: 2395–2405. [Abstract] [Full Text] [PDF]
	Second Malignancies After Treatment of Early-Stage Breast Cancer: Lumpectomy and Radiation Therapy Versus Mastectomy
	Edward Obedian, Diana B. Fischer, and Bruce G. Haffty
	JCO Jun 12 2000: 2406–2412. [Abstract] [Full Text] [PDF]

GENITOURINARY CANCER
	Paclitaxel, Ifosfamide, and Cisplatin Second-Line Therapy for Patients With Relapsed Testicular Germ Cell Cancer
	Robert J. Motzer, Joel Sheinfeld, Madhu Mazumdar, Manjit Bains, Tania Mariani, Jennifer Bacik, Dean Bajorin, and George J. Bosl
	JCO Jun 12 2000: 2413–2418. [Abstract] [Full Text] [PDF]
	Phase II Trial of Weekly Intravenous Gemcitabine With Continuous Infusion Fluorouracil in Patients With Metastatic Renal Cell Cancer
	Brian I. Rini, Nicholas J. Vogelzang, Mary C. Dumas, James L. Wade, III, David A. Taber, and Walter M. Stadler
	JCO Jun 12 2000: 2419–2426. [Abstract] [Full Text] [PDF]

PEDIATRIC ONCOLOGY
	Benefit of Intensified Therapy for Patients With Local or Regional Embryonal Rhabdomyosarcoma: Results From the Intergroup Rhabdomyosarcoma Study IV
	K. Scott Baker, James R. Anderson, Michael P. Link, Holcombe E. Grier, Stephen J. Qualman, Harold M. Maurer, John C. Breneman, Eugene S. Wiener, and William M. Crist
	JCO Jun 12 2000: 2427–2434. [Abstract] [Full Text] [PDF]
	Second Cancers Among Long-Term Survivors of Hodgkin’s Disease Diagnosed in Childhood and Adolescence
	Catherine Metayer, Charles F. Lynch, E. Aileen Clarke, Bengt Glimelius, Hans Storm, Eero Pukkala, Timo Joensuu, Flora E. van Leeuwen, Mars B. van’t Veer, Rochelle E. Curtis, Eric J. Holowaty, Michael Andersson, Tom Wiklund, Mary Gospodarowicz, and Lois B. Travis
	JCO Jun 12 2000: 2435–2443. [Abstract] [Full Text] [PDF]

MELANOMA
	High- and Low-Dose Interferon Alfa-2b in High-Risk Melanoma: First Analysis of Intergroup Trial E1690/S9111/C9190
	John M. Kirkwood, Joseph G. Ibrahim, Vernon K. Sondak, Jon Richards, Lawrence E. Flaherty, Marc S. Ernstoff, Thomas J. Smith, Uma Rao, Mary Steele, and Ronald H. Blum
	JCO Jun 12 2000: 2444–2458. [Abstract] [Full Text] [PDF]

PHASE I AND CLINICAL PHARMACOLOGY
	Population Pharmacokinetic Model for Topotecan Derived From Phase I Clinical Trials
	James M. Gallo, Paul B. Laub, Eric K. Rowinsky, Louise B. Grochow, and Sharyn D. Baker
	JCO Jun 12 2000: 2459–2467. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacokinetic Study of Oral Paclitaxel
	Mirte M. Malingré, Jetske M. Meerum Terwogt, Jos H. Beijnen, Hilde Rosing, Franciska J. Koopman, Olaf van Tellingen, Ken Duchin, Wim W. Ten Bokkel Huinink, Martha Swart, Jan Lieverst, and Jan H. M. Schellens
	JCO Jun 12 2000: 2468–2475. [Abstract] [Full Text] [PDF]
	Pharmacoeconomic Analysis of Liposomal Amphotericin B Versus Conventional Amphotericin B in the Empirical Treatment of Persistently Febrile Neutropenic Patients
	Pablo J. Cagnoni, Thomas J. Walsh, Mary M. Prendergast, David Bodensteiner, Sharon Hiemenz, Richard N. Greenberg, Carola A. S. Arndt, Mindy Schuster, Nita Seibel, Vijay Yeldandi, and Kuo B. Tong
	JCO Jun 12 2000: 2476–2483. [Abstract] [Full Text] [PDF]

SPECIAL ARTICLES
	What Would You Do? Specialists’ Perspectives on Cancer Genetic Testing, Prophylactic Surgery, and Insurance Discrimination
	Ellen T. Matloff, Heather Shappell, Karina Brierley, Barbara A. Bernhardt, Wendy McKinnon, and Beth N. Peshkin
	JCO Jun 12 2000: 2484–2492. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Chemotherapy in Neuroendocrine/Merkel Cell Carcinoma of the Skin: Case Series and Review of 204 Cases
	Patricia T. H. Tai, Edward Yu, Eric Winquist, Alex Hammond, Larry Stitt, Jon Tonita, and Jim Gilchrist
	JCO Jun 12 2000: 2493–2499. [Abstract] [Full Text] [PDF]

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