EDITORIALS

Adjuvant Chemotherapy for Adult Soft Tissue Sarcoma: Is There a Standard of Care?

Vivien H.C. Bramwell

JCO Mar 1 2001: 1235–1237. [Full Text] [PDF]

ORIGINAL REPORTS
Sarcomas
	Adjuvant Chemotherapy for Adult Soft Tissue Sarcomas of the Extremities and Girdles: Results of the Italian Randomized Cooperative Trial
	Sergio Frustaci, Franco Gherlinzoni, Antonino De Paoli, Marco Bonetti, Alberto Azzarelli, Alessandro Comandone, Patrizia Olmi, Angela Buonadonna, Giovanni Pignatti, Enza Barbieri, Gaetano Apice, Hassan Zmerly, Diego Serraino, and Piero Picci
	JCO Mar 1 2001: 1238–1247. [Abstract] [Full Text] [PDF]
	Ecteinascidin-743: A Marine-Derived Compound in Advanced, Pretreated Sarcoma Patients—Preliminary Evidence of Activity
	S. Delaloge, A. Yovine, A. Taamma, M. Riofrio, E. Brain, E. Raymond, P. Cottu, F. Goldwasser, J. Jimeno, J. L. Misset, M. Marty, and E. Cvitkovic
	JCO Mar 1 2001: 1248–1255. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacokinetic Study of Ecteinascidin-743, a New Marine Compound, Administered as a 24-hour Continuous Infusion in Patients With Solid Tumors
	A. Taamma, J. L. Misset, M. Riofrio, C. Guzman, E. Brain, L. Lopez Lazaro, H. Rosing, J. M. Jimeno, and E. Cvitkovic
	JCO Mar 1 2001: 1256–1265. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	Does Palliative Chemotherapy Palliate? Evaluation of Expectations, Outcomes, and Costs in Women Receiving Chemotherapy for Advanced Ovarian Cancer
	Catherine Doyle, Michael Crump, Melania Pintilie, and Amit M. Oza
	JCO Mar 1 2001: 1266–1274. [Abstract] [Full Text] [PDF]
	Paclitaxel, an Active Agent in Nonsquamous Carcinomas of the Uterine Cervix: A Gynecologic Oncology Group Study
	John P. Curtin, John A. Blessing, Kenneth D. Webster, Peter G. Rose, Allan R. Mayer, Wesley C. Fowler, Jr, John H. Malfetano, and Ronald D. Alvarez
	JCO Mar 1 2001: 1275–1278. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Glutathione S-Transferase Polymorphisms and Outcome of Chemotherapy in Childhood Acute Myeloid Leukemia
	Stella M. Davies, Leslie L. Robison, Jonathan D. Buckley, Tom Tjoa, William G. Woods, Gretchen A. Radloff, Julie A. Ross, and John P. Perentesis
	JCO Mar 1 2001: 1279–1287. [Abstract] [Full Text] [PDF]
	Postoperative Chemotherapy Without Irradiation for Ependymoma in Children Under 5 Years of Age: A Multicenter Trial of the French Society of Pediatric Oncology
	Jacques Grill, Marie-Cécile Le Deley, Danièle Gambarelli, Marie-Anne Raquin, Dominique Couanet, Alain Pierre-Kahn, Jean-Louis Habrand, François Doz, Didier Frappaz, Jean-Claude Gentet, Christine Edan, Pascal Chastagner, and Chantal Kalifa
	JCO Mar 1 2001: 1288–1296. [Abstract] [Full Text] [PDF]
	Effect of Protracted High-Dose L-Asparaginase Given as a Second Exposure in a Berlin-Frankfurt-Münster–Based Treatment: Results of the Randomized 9102 Intermediate-Risk Childhood Acute Lymphoblastic Leukemia Study—A Report From the Associazione Italiana Ematologia Oncologia Pediatrica
	C. Rizzari, M.G. Valsecchi, M. Aricò, V. Conter, A. Testi, E. Barisone, F. Casale, L. Lo Nigro, R. Rondelli, G. Basso, N. Santoro, and G. Masera
	JCO Mar 1 2001: 1297–1303. [Abstract] [Full Text] [PDF]

GENITOURINARY CANCER
	Serum Prostate-Specific Antigen Decline as a Marker of Clinical Outcome in Hormone-Refractory Prostate Cancer Patients: Association With Progression-Free Survival, Pain End Points, and Survival
	Eric J. Small, Alex McMillan, Mark Meyer, Liang Chen, William J. Slichenmyer, Peter F. Lenehan, and Mario Eisenberger
	JCO Mar 1 2001: 1304–1311. [Abstract] [Full Text] [PDF]
	Phase I Trial of 40-kd Branched Pegylated Interferon Alfa-2a for Patients With Advanced Renal Cell Carcinoma
	Robert J. Motzer, Ashok Rakhit, Michelle Ginsberg, Karen Rittweger, Jacqueline Vuky, Richard Yu, Scott Fettner, and Leon Hooftman
	JCO Mar 1 2001: 1312–1319. [Abstract] [Full Text] [PDF]

LUNG CANCER
	Phase II Trial of Paclitaxel and Carboplatin in Metastatic Small-Cell Lung Cancer: A Groupe Français de Pneumo-Cancérologie Study
	P. Thomas, O. Castelnau, D. Paillotin, H. Léna, G. Robinet, J. F. Muir, P. Delaval, S. Gouva, P. Balmes, F. Blanchon, D. Perdu, R. Poirier, P. Pommier de Santi, C. Penot-Ragon, and J. P. Kleisbauer
	JCO Mar 1 2001: 1320–1325. [Abstract] [Full Text] [PDF]
	Phase I Study of a Decision Aid for Patients With Locally Advanced Non–Small-Cell Lung Cancer
	M. D. Brundage, D. Feldman-Stewart, R. Cosby, R. Gregg, P. Dixon, Y. Youssef, D. Davies, and W. J. Mackillop
	JCO Mar 1 2001: 1326–1335. [Abstract] [Full Text] [PDF]
	Duration of Chemotherapy in Advanced Non–Small-Cell Lung Cancer: A Randomized Trial of Three Versus Six Courses of Mitomycin, Vinblastine, and Cisplatin
	Ian E. Smith, Mary E.R. O’Brien, Denis C. Talbot, Marianne C. Nicolson, Janine L. Mansi, Tamas F. Hickish, Alison Norton, and Susan Ashley
	JCO Mar 1 2001: 1336–1343. [Abstract] [Full Text] [PDF]
	Factors Affecting the Risk of Brain Metastases After Definitive Chemoradiation for Locally Advanced Non–Small-Cell Lung Carcinoma
	Theodore J. Robnett, Mitchell Machtay, James P. Stevenson, Kenneth M. Algazy, and Stephen M. Hahn
	JCO Mar 1 2001: 1344–1349. [Abstract] [Full Text] [PDF]

ORIGINAL REPORTS
Head and Neck Cancer
	Results of a Prospective Randomized Trial Comparing Neoadjuvant Chemotherapy Plus Radiotherapy With Radiotherapy Alone in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
	Jun Ma, Hai-Qiang Mai, Ming-Huang Hong, Hua-Qing Min, Zhi-Da Mao, Nian-Ji Cui, Tai-Xiang Lu, and Hao-Yuan Mo
	JCO Mar 1 2001: 1350–1357. [Abstract] [Full Text] [PDF]
	Synchronous and Metachronous Squamous Cell Carcinomas of the Head and Neck Mucosal Sites
	Haldun S. Erkal, William M. Mendenhall, Robert J. Amdur, Douglas B. Villaret, and Scott P. Stringer
	JCO Mar 1 2001: 1358–1362. [Abstract] [Full Text] [PDF]
	Phase I Study of Paclitaxel Given by Seven-Week Continuous Infusion Concurrent With Radiation Therapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck
	David I. Rosenthal, Jason H. Lee, Robert Sinard, Denise A. Yardley, Mitchell Machtay, D. Marc Rosen, Merrill J. Egorin, Randal S. Weber, Gregory S. Weinstein, Ara A. Chalian, Linda K. Miller, Eugene P. Frenkel, and David P. Carbone
	JCO Mar 1 2001: 1363–1373. [Abstract] [Full Text] [PDF]

Epidemiology
	Estimation of Risk of Inherited Medullary Thyroid Carcinoma in Apparent Sporadic Patients
	M. Wiench, Z. Wygoda, E. Gubala, J. Wloch, K. Lisowska, J. Krassowski, D. Scieglinska, A. Fiszer-Kierzkowska, D. Lange, D. Kula, M. Zeman, J. Roskosz, A. Kukulska, Z. Krawczyk, and B. Jarzab
	JCO Mar 1 2001: 1374–1380. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Reproductive Factors and Risk of Intermediate- or High-Grade B-Cell Non-Hodgkin’s Lymphoma in Women
	Rebecca A. Nelson, Alexandra M. Levine, and Leslie Bernstein
	JCO Mar 1 2001: 1381–1387. [Abstract] [Full Text] [PDF]
	Image-Aided Estimate of Tumor Burden in Hodgkin’s Disease: Evidence of Its Primary Prognostic Importance
	Paolo G. Gobbi, Maria L. Ghirardelli, Marco Solcia, Giuseppe Di Giulio, Francesco Merli, Luisa Tavecchia, Raffaella Bertè, Ottavio Davini, Alessandro Levis, Chiara Broglia, Gabriella Carnevale Maffè, Fiorella Ilariucci, Roberto Dore, and Edoardo Ascari
	JCO Mar 1 2001: 1388–1394. [Abstract] [Full Text] [PDF]
	Autologous Stem-Cell Transplantation for Hodgkin’s Disease: Results and Prognostic Factors in 494 Patients From the Grupo Español de Linfomas/Transplante Autólogo de Médula Ósea Spanish Cooperative Group
	A. Sureda, R. Arranz, A. Iriondo, E. Carreras, J.J. Lahuerta, J. García-Conde, I. Jarque, M.D. Caballero, C. Ferrà, A. López, J. García-Laraña, R. Cabrera, D. Carrera, M.D. Ruiz-Romero, A. León, J. Rifón, J. Díaz-Mediavilla, R. Mataix, M. Morey, J.M. Moraleda, A. Altés, A. López-Guillermo, J. de la Serna, J.M. Fernández-Rañada, J. Sierra, and E. Conde
	JCO Mar 1 2001: 1395–1404. [Abstract] [Full Text] [PDF]
	Mutations With Loss of Heterozygosity of p53 Are Common in Therapy-Related Myelodysplasia and Acute Myeloid Leukemia After Exposure to Alkylating Agents and Significantly Associated With Deletion or Loss of 5q, a Complex Karyotype, and a Poor Prognosis
	Debes H. Christiansen, Mette K. Andersen, and Jens Pedersen-Bjergaard
	JCO Mar 1 2001: 1405–1413. [Abstract] [Full Text] [PDF]
	Results of the Fludarabine and Cyclophosphamide Combination Regimen in Chronic Lymphocytic Leukemia
	Susan M. O’Brien, Hagop M. Kantarjian, Jorge Cortes, Miloslav Beran, Charles A. Koller, Francis J. Giles, Susan Lerner, and Michael Keating
	JCO Mar 1 2001: 1414–1420. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Pharmacokinetic Evaluation of N-[2-(Dimethylamino)Ethyl]Acridine-4-Carboxamide in Patients by Positron Emission Tomography
	Azeem Saleem, Robert J. Harte, Julian C. Matthews, Safiye Osman, Frank Brady, Sajinder K. Luthra, Gavin D. Brown, Norman Bleehen, Tom Connors, Terry Jones, Pat M. Price, and Eric O. Aboagye
	JCO Mar 1 2001: 1421–1429. [Abstract] [Full Text] [PDF]
	Phase I Study of ZD9331 on Short Daily Intravenous Bolus Infusion for 5 Days Every 3 Weeks With Fixed Dosing Recommendations
	B. C. Goh, M. J. Ratain, D. Bertucci, R. Smith, S. Mani, N. J. Vogelzang, R. L. Schilsky, M. Hutchison, M. Smith, S. Averbuch, and E. Douglass
	JCO Mar 1 2001: 1476–1484. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacokinetic Study of PKC412, an Inhibitor of Protein Kinase C
	D. J. Propper, A. C. McDonald, A. Man, P. Thavasu, F. Balkwill, J. P. Braybrooke, F. Caponigro, P. Graf, C. Dutreix, R. Blackie, S. B. Kaye, T. S. Ganesan, D. C. Talbot, A. L. Harris, and C. Twelves
	JCO Mar 1 2001: 1485–1492. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacokinetic Study of Exatecan Mesylate (DX-8951f): A Novel Camptothecin Analog
	Melanie E. Royce, Paulo M. Hoff, Pamela Dumas, Yvonne Lassere, J. Jack Lee, John Coyle, Murray P. Ducharme, Robert De Jager, and Richard Pazdur
	JCO Mar 1 2001: 1493–1500. [Abstract] [Full Text] [PDF]

Melanoma
	High-Dose Interferon Alfa-2b Does Not Diminish Antibody Response to GM2 Vaccination in Patients With Resected Melanoma: Results of the Multicenter Eastern Cooperative Oncology Group Phase II Trial E2696
	John M. Kirkwood, Joseph Ibrahim, David H. Lawson, Michael B. Atkins, Sanjiv S. Agarwala, Keirsten Collins, Ruth Mascari, Donna M. Morrissey, and Paul B. Chapman
	JCO Mar 1 2001: 1430–1436. [Abstract] [Full Text] [PDF]
	Detection of Occult Melanoma Cells in Paraffin-Embedded Histologically Negative Sentinel Lymph Nodes Using a Reverse Transcriptase Polymerase Chain Reaction Assay
	Giuseppe Palmieri, Paolo A. Ascierto, Antonio Cossu, Nicola Mozzillo, Maria L. Motti, Sabrina M.R. Satriano, Gerardo Botti, Corrado Caracò, Egidio Celentano, Rocco A. Satriano, Amelia Lissia, Francesco Tanda, Mario Pirastu, and Giuseppe Castello
	JCO Mar 1 2001: 1437–1443. [Abstract] [Full Text] [PDF]

Breast Cancer
	Reduced Cardiotoxicity and Preserved Antitumor Efficacy of Liposome-Encapsulated Doxorubicin and Cyclophosphamide Compared With Conventional Doxorubicin and Cyclophosphamide in a Randomized, Multicenter Trial of Metastatic Breast Cancer
	Gerald Batist, Gopal Ramakrishnan, Chandra Sekhar Rao, Aruna Chandrasekharan, John Gutheil, Troy Guthrie, Pankaj Shah, Ali Khojasteh, Madhavan Krishnan Nair, Karen Hoelzer, Katherine Tkaczuk, Youn Choi Park, and Lily W. Lee
	JCO Mar 1 2001: 1444–1454. [Abstract] [Full Text] [PDF]
	Patterns of Use of Chemotherapy for Breast Cancer in Older Women: Findings From Medicare Claims Data
	Xianglin Du and James S. Goodwin
	JCO Mar 1 2001: 1455–1461. [Abstract] [Full Text] [PDF]
	Nipple Fluid Carcinoembryonic Antigen and Prostate-Specific Antigen in Cancer-Bearing and Tumor-Free Breasts
	Yashuang Zhao, Sigitas J. Verselis, Neil Klar, Norman L. Sadowsky, Carolyn M. Kaelin, Barbara Smith, Lenka Foretova, and Frederick P. Li
	JCO Mar 1 2001: 1462–1467. [Abstract] [Full Text] [PDF]
	Comparative Analysis of Micrometastasis to the Bone Marrow and Lymph Nodes of Node-Negative Breast Cancer Patients Receiving No Adjuvant Therapy
	Stephan Braun, B. Semeni Cevatli, Cyamak Assemi, Wolfgang Janni, Christina R.M. Kentenich, Christian Schindlbeck, Dorothea Rjosk, and Florian Hepp
	JCO Mar 1 2001: 1468–1475. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Irinotecan in the Treatment of Colorectal Cancer: Clinical Overview
	Udo Vanhoefer, Andreas Harstrick, Wolf Achterrath, Shousong Cao, Siegfried Seeber, and Youcef M. Rustum
	JCO Mar 1 2001: 1501–1518. [Abstract] [Full Text] [PDF]

ASCO SPECIAL ARTICLES
	Platelet Transfusion for Patients With Cancer: Clinical Practice Guidelines of the American Society of Clinical Oncology
	Charles A. Schiffer, Kenneth C. Anderson, Charles L. Bennett, Steven Bernstein, Linda S. Elting, Miriam Goldsmith, Michael Goldstein, Heather Hume, Jeffery J. McCullough, Rosemary E. McIntyre, Bayard L. Powell, John M. Rainey, Scott D. Rowley, Paolo Rebulla, Michael B. Troner, and Alton H. Wagnon
	JCO Mar 1 2001: 1519–1538. [Abstract] [Full Text] [PDF]
	Postmastectomy Radiotherapy: Clinical Practice Guidelines of the American Society of Clinical Oncology
	Abram Recht, Stephen B. Edge, Lawrence J. Solin, David S. Robinson, Alison Estabrook, Richard E. Fine, Gini F. Fleming, Silvia Formenti, Clifford Hudis, Jeffrey J. Kirshner, David A. Krause, Robert R. Kuske, Amy S. Langer, George W. Sledge, Jr, Timothy J. Whelan, and David G. Pfister
	JCO Mar 1 2001: 1539–1569. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Unusual Sites of Malignancy: Case 1. Primary Non-Hodgkin's Lymphoma of the Hand in a Patient With Hepatitis C Infection

Giuseppe Longo, Leonardo Potenza, Nicola D’Apollo, Leonardo Ferrara, Giovanna Gandini, Marcello Bertesi, Giuseppe Torelli, and Giovanni Emilia

JCO Mar 1 2001: 1570–1572. [Full Text] [PDF]

Unusual Sites of Malignancy: Case 2. Orbital Lymphoma

Anthony Abner, Roger Lange, and Gregory Gauvin

JCO Mar 1 2001: 1572–1573. [Full Text] [PDF]

Unusual Sites of Malignancy: Case 3. Solitary Splenic Metastasis in Lung Cancer With Spontaneous Rupture

Suleiman Massarweh and Hari Dhingra

JCO Mar 1 2001: 1574–1575. [Full Text] [PDF]

ART OF ONCOLOGY

Discussing Do-Not-Resuscitate Status

Charles F. von Gunten

JCO Mar 1 2001: 1576–1581. [Full Text] [PDF]

SPECIAL DEPARTMENTS

CORRESPONDENCE

Clarification on the Potential of Subcutaneous Ethyol as a Radioprotective Agent

Karen D. Godette, Charles R. Thomas, Jr, and Michael I. Koukourakis

JCO Mar 1 2001: 1582–1583. [Full Text] [PDF]

Patients Aged 70 Are at High Risk for Neutropenic Infection and Should Receive Hemopoietic Growth Factors When Treated With Moderately Toxic Chemotherapy

Lodovico Balducci, Gary H. Lyman, and Howard Ozer

JCO Mar 1 2001: 1583–1585. [Full Text] [PDF]

ERRATA

Correction for vol. 19, p. 273

JCO Mar 1 2001: 1585. [Full Text] [PDF]

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