EDITORIALS

Chemoprevention of Breast Cancer: A Model for Change

V. Craig Jordan and Monica Morrow

JCO Jan 1 2002: 1–3. [Full Text] [PDF]

Asking the Obvious Questions Regarding Patient Burden

Jeff Sloan

JCO Jan 1 2002: 4–6. [Full Text] [PDF]

Irinotecan Dosing: Does the CPT in CPT-11 Stand for "Can’t Predict Toxicity"?

Mark J. Ratain

JCO Jan 1 2002: 7–8. [Full Text] [PDF]

ORIGINAL REPORTS
Breast Cancer
	Outcomes of Tamoxifen Chemoprevention for Breast Cancer in Very High-Risk Women: A Cost-Effectiveness Analysis
	Dawn Hershman, Vijaya Sundararajan, Judith S. Jacobson, Daniel F. Heitjan, Alfred I. Neugut, and Victor R. Grann
	JCO Jan 1 2002: 9–16. [Abstract] [Full Text] [PDF]
	Predictors of Local-Regional Recurrence After Neoadjuvant Chemotherapy and Mastectomy Without Radiation
	Thomas A. Buchholz, Susan L. Tucker, Lawrence Masullo, Henry M. Kuerer, Jessica Erwin, Jessica Salas, Debbie Frye, Eric A. Strom, Marsha D. McNeese, George Perkins, Angela Katz, S. Eva Singletary, Kelly K. Hunt, Aman U. Buzdar, and Gabriel N. Hortobagyi
	JCO Jan 1 2002: 17–23. [Abstract] [Full Text] [PDF]
	Randomized, Controlled, Dose-Range Study of Ro 25-8315 Given Before and After a High-Dose Combination Chemotherapy Regimen in Patients With Metastatic or Recurrent Breast Cancer Patients
	P. Viens, C. Chabannon, P. Pouillard, M. Janvier, W. Brugger, J. Y. Blay, F. Oberling, R. Capdeville, C. Newman, V. Méresse, Z. X. Xu, E. Platzer, P. Van der Auwera, and D. Maraninchi
	JCO Jan 1 2002: 24–36. [Abstract] [Full Text] [PDF]
	Phase II Trial of Biweekly Administration of Vinorelbine and Gemcitabine in Pretreated Advanced Breast Cancer
	George P. Stathopoulos, Sotiris K. Rigatos, Nikos Pergantas, Dimitris Tsavdarides, Ilias Athanasiadis, Nikos A. Malamos, and John G. Stathopoulos
	JCO Jan 1 2002: 37–41. [Abstract] [Full Text] [PDF]
	Fasting Insulin and Outcome in Early-Stage Breast Cancer: Results of a Prospective Cohort Study
	Pamela J. Goodwin, Marguerite Ennis, Kathleen I. Pritchard, Maureen E. Trudeau, Jarley Koo, Yolanda Madarnas, Warren Hartwick, Barry Hoffman, and Nicky Hood
	JCO Jan 1 2002: 42–51. [Abstract] [Full Text] [PDF]
	Survey of Modalities of Toxicity Assessment and Reporting in Noncomparative Prospective Studies of Chemotherapy in Breast Cancer
	Francesco Perrone, Ermelinda De Maio, Paolo Maione, Massimo Di Maio, Alessandro Ottaiano, Matilde Pensabene, Giuseppe Di Lorenzo, Alessandra Vernaglia Lombardi, and Ciro Gallo
	JCO Jan 1 2002: 52–57. [Abstract] [Full Text] [PDF]
	Reinfusion of Autologous Lymphocytes With Granulocyte-Macrophage Colony-Stimulating Factor Induces Rapid Recovery of CD4+ and CD8+ T Cells After High-Dose Chemotherapy for Metastatic Breast Cancer
	G. C. de Gast, F. A. Vyth-Dreese, W. Nooijen, C. J.C. van den Bogaard, J. Sein, M. M.J. Holtkamp, G. A.M. Linthorst, J. W. Baars, J. H. Schornagel, and S. Rodenhuis
	JCO Jan 1 2002: 58–64. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Patients’ Estimation of Overall Treatment Burden: Why Not Ask the Obvious?
	J. Bernhard, R. Maibach, B. Thürlimann, C. Sessa, and M. S. Aapro
	JCO Jan 1 2002: 65–72. [Abstract] [Full Text] [PDF]
	Quality of Life in Long-Term Survivors of Testicular Cancer: A Population-Based Case-Control Study
	F. Joly, J. F. Héron, L. Kalusinski, P. Bottet, D. Brune, N. Allouache, J. Macé-Lesec’h, J. E. Couëtte, J. Pény, and M. Henry-Amar
	JCO Jan 1 2002: 73–80. [Abstract] [Full Text] [PDF]
	Safety and Efficacy of Alteplase for Restoring Function in Occluded Central Venous Catheters: Results of the Cardiovascular Thrombolytic to Open Occluded Lines Trial
	Steven R. Deitcher, Mark R. Fesen, Paul M. Kiproff, Patricia A. Hill, Xin Li, Edward R. McCluskey, and Charles P. Semba
	JCO Jan 1 2002: 317–324. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Impact of Body-Size Measures on Irinotecan Clearance: Alternative Dosing Recommendations
	Ron H.J. Mathijssen, Jaap Verweij, Maja J.A. de Jonge, Kees Nooter, Gerrit Stoter, and Alex Sparreboom
	JCO Jan 1 2002: 81–87. [Abstract] [Full Text] [PDF]
	Phase I Study of Combination Topotecan and Carboplatin in Pediatric Solid Tumors
	Uma H. Athale, Clinton Stewart, John F. Kuttesch, Albert Moghrabi, William Meyer, Charles Pratt, Amar Gajjar, and Richard L. Heideman
	JCO Jan 1 2002: 88–95. [Abstract] [Full Text] [PDF]
	Troxacitabine, an L-Stereoisomeric Nucleoside Analog, on a Five-Times-Daily Schedule: A Phase I and Pharmacokinetic Study in Patients With Advanced Solid Malignancies
	Johann S. de Bono, Joseph Stephenson, Jr, Sharyn D. Baker, Manuel Hidalgo, Amita Patnaik, Lisa A. Hammond, Geoffrey Weiss, Andrew Goetz, Lillian Siu, Cecelia Simmons, Jacques Jolivet, and Eric K. Rowinsky
	JCO Jan 1 2002: 96–109. [Abstract] [Full Text] [PDF]
	Pharmacodynamic Studies of the Epidermal Growth Factor Receptor Inhibitor ZD1839 in Skin From Cancer Patients: Histopathologic and Molecular Consequences of Receptor Inhibition
	Joan Albanell, Federico Rojo, Steve Averbuch, Andrea Feyereislova, Jose Manuel Mascaro, Roy Herbst, Patricia LoRusso, Danny Rischin, Silvia Sauleda, Julia Gee, Robert I. Nicholson, and Jose Baselga
	JCO Jan 1 2002: 110–124. [Abstract] [Full Text] [PDF]

Melanoma
	Results From a Randomized Phase III Study Comparing Combined Treatment With Histamine Dihydrochloride Plus Interleukin-2 Versus Interleukin-2 Alone in Patients With Metastatic Melanoma
	Sanjiv S. Agarwala, John Glaspy, Steven J. O’Day, Malcolm Mitchell, John Gutheil, Eric Whitman, Rene Gonzalez, Evan Hersh, Lynn Feun, Robert Belt, Frank Meyskens, Kristoffer Hellstrand, Diana Wood, John M. Kirkwood, Kurt R. Gehlsen, and Peter Naredi
	JCO Jan 1 2002: 125–133. [Abstract] [Full Text] [PDF]
	Melanoma Information on the Internet: Often Incomplete—A Public Health Opportunity?
	Christopher K. Bichakjian, Jennifer L. Schwartz, Timothy S. Wang, Janette M. Hall, Timothy M. Johnson, and J. Sybil Biermann
	JCO Jan 1 2002: 134–141. [Abstract] [Full Text] [PDF]
	Phase I Study of the Intravenous Administration of Attenuated Salmonella typhimurium to Patients With Metastatic Melanoma
	John F. Toso, Vee J. Gill, Patrick Hwu, Francesco M. Marincola, Nicholas P. Restifo, Douglas J. Schwartzentruber, Richard M. Sherry, Suzanne L. Topalian, James C. Yang, Frida Stock, Linda J. Freezer, Kathleen E. Morton, Claudia Seipp, Leah Haworth, Sharon Mavroukakis, Donald White, Susan MacDonald, John Mao, Mario Sznol, and Steven A. Rosenberg
	JCO Jan 1 2002: 142–152. [Abstract] [Full Text] [PDF]

AIDS Related Cancer
	Matrix Metalloproteinase Inhibitor COL-3 in the Treatment of AIDS-Related Kaposi’s Sarcoma: A Phase I AIDS Malignancy Consortium Study
	Mary Cianfrocca, Timothy P. Cooley, Jeannette Y. Lee, Michelle A. Rudek, David T. Scadden, Lee Ratner, James M. Pluda, William D. Figg, Susan E. Krown, and Bruce J. Dezube
	JCO Jan 1 2002: 153–159. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Phase II Study of Oral Capecitabine in Patients With Advanced or Metastatic Pancreatic Cancer
	Thomas H. Cartwright, Allen Cohn, Jerry A. Varkey, Yin-Miao Chen, Ted P. Szatrowski, John V. Cox, and Joseph J. Schulz
	JCO Jan 1 2002: 160–164. [Abstract] [Full Text] [PDF]
	Randomized Multicenter Phase II Trial of Oxaliplatin Plus Irinotecan Versus Raltitrexed as First-Line Treatment in Advanced Colorectal Cancer
	Werner Scheithauer, Gabriela V. Kornek, Markus Raderer, Herbert Ulrich-Pur, Wolfgang Fiebiger, Claudia Gedlicka, Birgit Schüll, Stefan Brugger, Bruno Schneeweiss, Fritz Lang, Alfred Lenauer, and Dieter Depisch
	JCO Jan 1 2002: 165–172. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	Variations in the Use of Chemotherapy for Elderly Patients With Advanced Ovarian Cancer: A Population-Based Study
	Vijaya Sundararajan, Dawn Hershman, Victor R. Grann, Judith S. Jacobson, and Alfred I. Neugut
	JCO Jan 1 2002: 173–178. [Abstract] [Full Text] [PDF]
	Neoadjuvant Chemotherapy and Radical Surgery Versus Exclusive Radiotherapy in Locally Advanced Squamous Cell Cervical Cancer: Results From the Italian Multicenter Randomized Study
	Pierluigi Benedetti-Panici, Stefano Greggi, Alessandro Colombo, Mariangela Amoroso, Daniela Smaniotto, Diana Giannarelli, Gianni Amunni, Francesco Raspagliesi, Paolo Zola, Costantino Mangioni, and Fabio Landoni
	JCO Jan 1 2002: 179–188. [Abstract] [Full Text] [PDF]

Sarcomas
	High-Dose Samarium-153 Ethylene Diamine Tetramethylene Phosphonate: Low Toxicity of Skeletal Irradiation in Patients With Osteosarcoma and Bone Metastases
	Peter M. Anderson, Gregory A. Wiseman, Angela Dispenzieri, Carola A.S. Arndt, Lynn C. Hartmann, William A. Smithson, Brian P. Mullan, and Oyvind S. Bruland
	JCO Jan 1 2002: 189–196. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Brief Chemotherapy and Involved-Region Irradiation for Limited-Stage Diffuse Large-Cell Lymphoma: An 18-Year Experience From the British Columbia Cancer Agency
	Tamara N. Shenkier, Nicholas Voss, Randall Fairey, Randy D. Gascoyne, Paul Hoskins, Richard Klasa, Paul Klimo, Susan E. O’Reilly, Simon Sutcliffe, and Joseph M. Connors
	JCO Jan 1 2002: 197–204. [Abstract] [Full Text] [PDF]
	Campath-1H Treatment of T-Cell Prolymphocytic Leukemia in Patients for Whom at Least One Prior Chemotherapy Regimen Has Failed
	M. J. Keating, B. Cazin, S. Coutré, R. Birhiray, T. Kovacsovics, W. Langer, B. Leber, T. Maughan, K. Rai, G. Tjønnfjord, M. Bekradda, M. Itzhaki, and P. Hérait
	JCO Jan 1 2002: 205–213. [Abstract] [Full Text] [PDF]
	Follow-Up of Complete Cytogenetic Remission in Patients With Chronic Myeloid Leukemia After Cessation of Interferon Alfa
	F. X. Mahon, X. Delbrel, P. Cony-Makhoul, C. Fabères, J. M. Boiron, C. Barthe, C. Bilhou-Nabéra, A. Pigneux, G. Marit, and J. Reiffers
	JCO Jan 1 2002: 214–220. [Abstract] [Full Text] [PDF]
	New Prognostic Score Based on Treatment Outcome of Patients With Relapsed Hodgkin’s Lymphoma Registered in the Database of the German Hodgkin’s Lymphoma Study Group
	Andreas Josting, Jeremy Franklin, Michael May, Peter Koch, Maria K. Beykirch, Juergen Heinz, Christian Rudolph, Volker Diehl, and Andreas Engert
	JCO Jan 1 2002: 221–230. [Abstract] [Full Text] [PDF]
	Importance of Radiotherapy in the Outcome of Patients With Primary CNS Lymphoma: An Analysis of the CHOD/BVAM Regimen Followed by Two Different Radiotherapy Treatments
	E. M. Bessell, A. López-Guillermo, S. Villá, E. Verger, B. Nomdedeu, J. Petit, P. Byrne, E. Montserrat, and F. Graus
	JCO Jan 1 2002: 231–236. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Treatment of Childhood Acute Lymphoblastic Leukemia: Results of Dana-Farber ALL Consortium Protocol 87-01
	Jean Marie LeClerc, Amy L. Billett, Richard D. Gelber, Virginia Dalton, Nancy Tarbell, Jeffrey M. Lipton, Ronald Barr, Luis A. Clavell, Barbara Asselin, Craig Hurwitz, Marshall Schorin, Steven E. Lipshultz, Lieven Declerck, Lewis B. Silverman, Harvey J. Cohen, and Stephen E. Sallan
	JCO Jan 1 2002: 237–246. [Abstract] [Full Text] [PDF]

Lung Cancer
	Preoperative Chemotherapy Followed by Surgery Compared With Primary Surgery in Resectable Stage I (Except T1N0), II, and IIIa Non–Small-Cell Lung Cancer
	Alain Depierre, Bernard Milleron, Denis Moro-Sibilot, Sylvie Chevret, Elisabeth Quoix, Bernard Lebeau, Denis Braun, Jean-Luc Breton, Etienne Lemarié, Sylvie Gouva, Nadine Paillot, Jeanne-Marie Bréchot, Henri Janicot, François-Xavier Lebas, Philippe Terrioux, Jean Clavier, Pascal Foucher, Michel Monchâtre, Daniel Coëtmeur, Marie-Claude Level, Pascal Leclerc, François Blanchon, Jean-Michel Rodier, Luc Thiberville, Anne Villeneuve, Virginie Westeel, and Claude Chastang
	JCO Jan 1 2002: 247–253. [Abstract] [Full Text] [PDF]
	Cooperative Role of Telomerase Activity and p16 Expression in the Prognosis of Non–Small-Cell Lung Cancer
	Rosa González-Quevedo, Pilar Iniesta, Alberto Morán, Carmen de Juan, Andrés Sánchez-Pernaute, C. Fernández, Antonio Torres, E. Díaz-Rubio, Jose-Luis Balibrea, and Manuel Benito
	JCO Jan 1 2002: 254–262. [Abstract] [Full Text] [PDF]
	Outcomes and Cost-Effectiveness of Alternative Staging Strategies for Non–Small-Cell Lung Cancer
	Nestor F. Esnaola, Sophia N. Lazarides, Steven J. Mentzer, and Karen M. Kuntz
	JCO Jan 1 2002: 263–273. [Abstract] [Full Text] [PDF]
	Phase II Trial of a Single Weekly Intravenous Dose of Ranpirnase in Patients With Unresectable Malignant Mesothelioma
	Stanislaw M. Mikulski, John J. Costanzi, Nicholas J. Vogelzang, Spence McCachren, Robert N. Taub, Hoo Chun, Abraham Mittelman, Timothy Panella, Carmelo Puccio, Robert Fine, and Kuslima Shogen
	JCO Jan 1 2002: 274–281. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Increased Risk of Ischemic Stroke After Radiotherapy on the Neck in Patients Younger Than 60 Years
	Lucille D.A. Dorresteijn, Arnoud C. Kappelle, Willem Boogerd, Willem J. Klokman, Alfons J.M. Balm, Ronald B. Keus, Flora E. van Leeuwen, and Harry Bartelink
	JCO Jan 1 2002: 282–288. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Interferon-Alfa as a Comparative Treatment for Clinical Trials of New Therapies Against Advanced Renal Cell Carcinoma
	Robert J. Motzer, Jennifer Bacik, Barbara A. Murphy, Paul Russo, and Madhu Mazumdar
	JCO Jan 1 2002: 289–296. [Abstract] [Full Text] [PDF]
	Salvage Chemotherapy for Patients With Advanced Pure Seminoma
	Jacqueline Vuky, Satish K. Tickoo, Joel Sheinfeld, Jennifer Bacik, Alison Amsterdam, Madhu Mazumdar, Victor Reuter, Dean F. Bajorin, George J. Bosl, and Robert J. Motzer
	JCO Jan 1 2002: 297–301. [Abstract] [Full Text] [PDF]
	Phase II Trial of Thalidomide for Patients With Advanced Renal Cell Carcinoma
	Robert J. Motzer, William Berg, Michelle Ginsberg, Paul Russo, Jacqueline Vuky, Richard Yu, Jennifer Bacik, and Madhu Mazumdar
	JCO Jan 1 2002: 302–306. [Abstract] [Full Text] [PDF]

Cost Effectiveness
	Costs of Treatment for Elderly Women With Early-Stage Breast Cancer in Fee-for-Service Settings
	Joan L. Warren, Martin L. Brown, Michael P. Fay, Nicola Schussler, Arnold L. Potosky, and Gerald F. Riley
	JCO Jan 1 2002: 307–316. [Abstract] [Full Text] [PDF]

BIOLOGY OF NEOPLASIA
	STI571: A Paradigm of New Agents for Cancer Therapeutics
	Michael J. Mauro, Michael O’Dwyer, Michael C. Heinrich, and Brian J. Druker
	JCO Jan 1 2002: 325–334. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Palliative Uses of Methylphenidate in Patients With Cancer: A Review
	Mark Rozans, Albert Dreisbach, Juan J.L. Lertora, and Marc J. Kahn
	JCO Jan 1 2002: 335–339. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Extramedullary Sites of Involvement in Hematologic Malignancies: Case 1. Multifocal Intracranial Involvement with Mantle-Cell Lymphoma

Asad Dean, Thomas E. Rogers, Jan Diehl, and Jonathan E. Dowell

JCO Jan 1 2002: 340–342. [Full Text] [PDF]

Extramedullary Sites of Involvement in Hematologic Malignancies: Case 2. Lymphocyte Morphology in Splenic Marginal Zone Lymphoma

Roger G. Owen

JCO Jan 1 2002: 342–344. [Full Text] [PDF]

Extramedullary Sites of Involvement in Hematologic Malignancies: Case 3. Hemorrhagic Gastric Plasmacytoma as the Primary Presentation in Multiple Myeloma

C. S. Chim, W. M. Wong, J. Nicholls, L. P. Chung, and R. Liang

JCO Jan 1 2002: 344–347. [Full Text] [PDF]

ART OF ONCOLOGY

Opioid Rotation in the Management of Refractory Cancer Pain

Rose Anne Indelicato and Russell K. Portenoy

JCO Jan 1 2002: 348–352. [Full Text] [PDF]

SPECIAL DEPARTMENTS

CORRESPONDENCE

Replacement of Carboplatin by Oxaliplatin May be One Solution for Patients Treated for Ovarian Carcinoma Who Are Hypersensitive to Carboplatin

M. Gutierrez, P. Pautier, and C. Lhommé

JCO Jan 1 2002: 353. [Full Text] [PDF]

Human Bone Marrow Myeloma Cells Express RANKL

Orhan Sezer, Ulrike Heider, Christian Jakob, Jan Eucker, Kurt Possinger, and G. David Roodman

JCO Jan 1 2002: 353-a–354. [Full Text] [PDF]

Tumor Lysis Syndrome After STI571 in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

Eldad J. Dann, Riva Fineman, and Jacob M. Rowe

JCO Jan 1 2002: 354–355. [Full Text] [PDF]

Radiation Recall Dermatitis From High-Dose Interferon Alfa-2b

Rosalyn Thomas and Baldassarre Stea

JCO Jan 1 2002: 355–357. [Full Text] [PDF]

Treatment of Intracranial Metastatic Esthesioneuroblastoma

Marc C. Chamberlain

JCO Jan 1 2002: 357–358. [Full Text] [PDF]

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