EDITORIALS

Quality Trials and Quality of Life in Non–Small-Cell Lung Cancer

Peter Harper, Tim Plunkett, and David Khayat

JCO Aug 15 2003: 3007–3008. First published on Jul 1 2003; 10.1200/JCO.2003.05.079. [Full Text] [PDF]

Platin or No Platin? That Is the Question

Joan H. Schiller

JCO Aug 15 2003: 3009–3010. First published on Jul 1 2003; 10.1200/JCO.2003.76.018. [Full Text] [PDF]

Bioweapons of Tumor Mass Destruction?

Martin J.S. Dyer

JCO Aug 15 2003: 3011–3012. First published on Jul 1 2003; 10.1200/JCO.2003.04.155. [Full Text] [PDF]

The Myth of Measurable Disease in Ovarian Cancer

Maurie Markman

JCO Aug 15 2003: 3013–3015. [Full Text] [PDF]

ORIGINAL REPORTS
Lung Cancer
	Randomized, Multinational, Phase III Study of Docetaxel Plus Platinum Combinations Versus Vinorelbine Plus Cisplatin for Advanced Non–Small-Cell Lung Cancer: The TAX 326 Study Group
	Frank Fossella, Jose R. Pereira, Joachim von Pawel, Anna Pluzanska, Vera Gorbounova, Eckhard Kaukel, Karin V. Mattson, Rodryg Ramlau, Aleksandra Szczesna, Panagiotis Fidias, Michael Millward, and Chandra P. Belani
	JCO Aug 15 2003: 3016–3024. First published on Jul 1 2003; 10.1200/JCO.2003.12.046. [Abstract] [Full Text] [PDF]
	Gemcitabine Plus Vinorelbine Compared With Cisplatin Plus Vinorelbine or Cisplatin Plus Gemcitabine for Advanced Non–Small-Cell Lung Cancer: A Phase III Trial of the Italian GEMVIN Investigators and the National Cancer Institute of Canada Clinical Trials Group
	Cesare Gridelli, Ciro Gallo, Frances A. Shepherd, Alfonso Illiano, Francovito Piantedosi, Sergio Federico Robbiati, Luigi Manzione, Santi Barbera, Luciano Frontini, Enzo Veltri, Brian Findlay, Silvio Cigolari, Robert Myers, Giovanni P. Ianniello, Vittorio Gebbia, Giampietro Gasparini, Sergio Fava, Vera Hirsh, Andrea Bezjak, Lesley Seymour, and Francesco Perrone
	JCO Aug 15 2003: 3025–3034. First published on Jul 1 2003; 10.1200/JCO.2003.06.099. [Abstract] [Full Text] [PDF]
	Conditional Survival of Patients With the Four Major Histologic Subgroups of Lung Cancer in Denmark
	Halla Skuladottir and Jørgen H. Olsen
	JCO Aug 15 2003: 3035–3040. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	CHOP Compared With CHOP Plus Granulocyte Colony-Stimulating Factor in Elderly Patients With Aggressive Non-Hodgkin’s Lymphoma
	J.K. Doorduijn, B. van der Holt, G.W. van Imhoff, K.G. van der Hem, M.H.H. Kramer, M.H.J. van Oers, G.J. Ossenkoppele, M.R. Schaafsma, L.F. Verdonck, G.E.G. Verhoef, M.M.C. Steijaert, I. Buijt, C.A. Uyl-de Groot, M. van Agthoven, A.H. Mulder, and P. Sonneveld
	JCO Aug 15 2003: 3041–3050. [Abstract] [Full Text] [PDF]
	Phase I/II Trial of Epratuzumab (Humanized Anti-CD22 Antibody) in Indolent Non-Hodgkin’s Lymphoma
	John P. Leonard, Morton Coleman, Jamie C. Ketas, Amy Chadburn, Scott Ely, Richard R. Furman, William A. Wegener, Hans J. Hansen, Heather Ziccardi, Michael Eschenberg, Urte Gayko, Alessandra Cesano, and David M. Goldenberg
	JCO Aug 15 2003: 3051–3059. First published on Jul 1 2003; 10.1200/JCO.2003.01.082. [Abstract] [Full Text] [PDF]
	Durable Remissions of Myelodysplastic Syndrome and Acute Myeloid Leukemia After Reduced-Intensity Allografting
	D.C. Taussig, A.J. Davies, J.D. Cavenagh, H. Oakervee, D. Syndercombe-Court, S. Kelsey, J.A.L. Amess, A.Z.S. Rohatiner, T.A. Lister, and M.J. Barnett
	JCO Aug 15 2003: 3060–3065. [Abstract] [Full Text] [PDF]
	Risk of Acute Leukemia Following Epirubicin-Based Adjuvant Chemotherapy: A Report From the National Cancer Institute of Canada Clinical Trials Group
	Michael Crump, Dongsheng Tu, Lois Shepherd, Mark Levine, Vivien Bramwell, and Kathleen Pritchard
	JCO Aug 15 2003: 3066–3071. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	High-Dose Therapy for Patients With Primary Multifocal and Early Relapsed Ewing’s Tumors: Results of Two Consecutive Regimens Assessing the Role of Total-Body Irradiation
	S. Burdach, A. Meyer-Bahlburg, H.J. Laws, R. Haase, B. van Kaik, B. Metzner, A. Wawer, R. Finke, U. Göbel, J. Haerting, H. Pape, H. Gadner, J. Dunst, and H. Juergens
	JCO Aug 15 2003: 3072–3078. [Abstract] [Full Text] [PDF]
	Patterns of Failure Using a Conformal Radiation Therapy Tumor Bed Boost for Medulloblastoma
	Suzanne L. Wolden, Ira J. Dunkel, Mark M. Souweidane, Laura Happersett, Yasmin Khakoo, Karen Schupak, David Lyden, and Steven A. Leibel
	JCO Aug 15 2003: 3079–3083. [Abstract] [Full Text] [PDF]
	Homocysteine, Pharmacogenetics, and Neurotoxicity in Children With Leukemia
	Shinji Kishi, James Griener, Cheng Cheng, Soma Das, Edwin H. Cook, Deqing Pei, Melissa Hudson, Jeffrey Rubnitz, John T. Sandlund, Ching-Hon Pui, and Mary V. Relling
	JCO Aug 15 2003: 3084–3091. [Abstract] [Full Text] [PDF]

SARCOMAS
	Phase I Trial of Preoperative Concurrent Doxorubicin and Radiation Therapy, Surgical Resection, and Intraoperative Electron-Beam Radiation Therapy for Patients With Localized Retroperitoneal Sarcoma
	Peter W.T. Pisters, Matthew T. Ballo, Mark J. Fenstermacher, Barry W. Feig, Kelly K. Hunt, Kevin A. Raymond, Michael A. Burgess, Gunar K. Zagars, Raphael E. Pollock, Robert S. Benjamin, and Shreyaskumar R. Patel
	JCO Aug 15 2003: 3092–3097. [Abstract] [Full Text] [PDF]

GASTROINTESTINAL CANCER
	Phase I/II Trial of Capecitabine, Oxaliplatin, and Radiation for Rectal Cancer
	Claus Rödel, Gerhard. G. Grabenbauer, Thomas Papadopoulos, Werner Hohenberger, Hans-Joachim Schmoll, and Rolf Sauer
	JCO Aug 15 2003: 3098–3104. [Abstract] [Full Text] [PDF]
	Automated, Multiplex Assay for High-Frequency Microsatellite Instability in Colorectal Cancer
	G.M. Nash, M. Gimbel, J. Shia, A.T. Culliford, D.R. Nathanson, M. Ndubuisi, Y. Yamaguchi, Z.S. Zeng, F. Barany, and P.B. Paty
	JCO Aug 15 2003: 3105–3112. [Abstract] [Full Text] [PDF]

GYNECOLOGIC CANCER
	Can Patients With Relapsed, Previously Untreated, Stage I Epithelial Ovarian Cancer Be Successfully Treated With Salvage Therapy?
	Desiree F. Kolomainen, Roger A’Hern, Fareeda Y. Coxon, Cyril Fisher, D. Michael King, Peter R. Blake, Desmond P.J. Barton, John H. Shepherd, Stanley B. Kaye, and Martin E. Gore
	JCO Aug 15 2003: 3113–3118. [Abstract] [Full Text] [PDF]
	Prognostic Value of the Human Kallikrein Gene 15 Expression in Ovarian Cancer
	George M. Yousef, Andreas Scorilas, Dionyssios Katsaros, Stefano Fracchioli, Lisa Iskander, Carla Borgono, Irene A. Rigault de la Longrais, Manuela Puopolo, Marco Massobrio, and Eleftherios P. Diamandis
	JCO Aug 15 2003: 3119–3126. [Abstract] [Full Text] [PDF]

ORIGINAL REPORTS
Genitourinary Cancer
	Randomized Study of High-Dose and Low-Dose Interleukin-2 in Patients With Metastatic Renal Cancer
	James C. Yang, Richard M. Sherry, Seth M. Steinberg, Suzanne L. Topalian, Douglas J. Schwartzentruber, Patrick Hwu, Claudia A. Seipp, Linda Rogers-Freezer, Kathleen E. Morton, Donald E. White, David J. Liewehr, Maria J. Merino, and Steven A. Rosenberg
	JCO Aug 15 2003: 3127–3132. [Abstract] [Full Text] [PDF]
	Adjuvant High-Dose Bolus Interleukin-2 for Patients With High-Risk Renal Cell Carcinoma: A Cytokine Working Group Randomized Trial
	Joseph I. Clark, Michael B. Atkins, Walter J. Urba, Steven Creech, Robert A. Figlin, Janice P. Dutcher, Larry Flaherty, Jeffrey A. Sosman, Theodore F. Logan, Richard White, Geoffrey R. Weiss, Bruce G. Redman, Christopher P.G. Tretter, David McDermott, John W. Smith, Michael S. Gordon, and Kim A. Margolin
	JCO Aug 15 2003: 3133–3140. First published on Jun 16 2003; 10.1200/JCO.2003.02.014. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	How to Optimize Physicians’ Communication Skills in Cancer Care: Results of a Randomized Study Assessing the Usefulness of Posttraining Consolidation Workshops
	Darius Razavi, Isabelle Merckaert, Serge Marchal, Yves Libert, Sandrine Conradt, Jacques Boniver, Anne-Marie Etienne, Ovide Fontaine, Pascal Janne, Jean Klastersky, Christine Reynaert, Pierre Scalliet, Jean-Louis Slachmuylder, and Nicole Delvaux
	JCO Aug 15 2003: 3141–3149. [Abstract] [Full Text] [PDF]
	Zoledronic Acid Versus Placebo in the Treatment of Skeletal Metastases in Patients With Lung Cancer and Other Solid Tumors: A Phase III, Double-Blind, Randomized Trial—The Zoledronic Acid Lung Cancer and Other Solid Tumors Study Group
	Lee S. Rosen, David Gordon, Simon Tchekmedyian, Ronald Yanagihara, Vera Hirsh, M. Krzakowski, M. Pawlicki, Paul de Souza, Ming Zheng, Gladys Urbanowitz, Dirk Reitsma, and John J. Seaman
	JCO Aug 15 2003: 3150–3157. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Importance of Predosing of Recombinant Human Thrombopoietin to Reduce Chemotherapy-Induced Early Thrombocytopenia
	Saroj Vadhan-Raj, Shreyaskumar Patel, Carlos Bueso-Ramos, Jody Folloder, Nicholas Papadopolous, Andrew Burgess, Lyle D. Broemeling, Hal E. Broxmeyer, and Robert S. Benjamin
	JCO Aug 15 2003: 3158–3167. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Challenging Problems in Advanced Malignancy: CASE 1. CHYLOPERICARDIUM DURING THE TREATMENT OF NON-HODGKIN’S LYMPHOMA

You-Hyun Lee, Seock-Ah Im, Seung-Hyun Nam, Si-Nae Lee, Yookyung Kim, Chu-Myong Seong, Woon Sup Han, Sun Wha Lee, Seong-Hoon Park, and Soon Nam Lee

JCO Aug 15 2003: 3168–3170. [Full Text] [PDF]

Challenging Problems in Advanced Malignancy: CASE 2. DISSEMINATED INTRAVASCULAR COAGULATION IN METASTATIC HORMONE-REFRACTORY PROSTATE CANCER

Lewis J. Kampel

JCO Aug 15 2003: 3170–3171. [Full Text] [PDF]

Challenging Problems in Advanced Malignancy: CASE 3. IMATINIB MESYLATE–INDUCED INTERSTITIAL PNEUMONITIS

Manuel F. Rosado, Elio Donna, and Yeon S. Ahn

JCO Aug 15 2003: 3171–3173. [Full Text] [PDF]

Challenging Problems in Advanced Malignancy: CASE 4. USE OF POSITRON EMISSION TOMOGRAPHY TO SOLVE A DIAGNOSTIC DILEMMA IN A PATIENT WITH NON-HODGKIN’S LYMPHOMA

B.T. Hennessy, A. Horgan, M. Hogan, J. Barry, S. O Reilly, and O. Breathnach

JCO Aug 15 2003: 3173–3176. [Full Text] [PDF]

SPECIAL DEPARTMENTS

Correspondence

Modified Fibonacci Search

George A. Omura

JCO Aug 15 2003: 3177. [Full Text] [PDF]

Pamidronate for Early-Stage, Untreated Myeloma

Pellegrino Musto, Antonietta Falcone, Grazia Sanpaolo, Carlo Bodenizza, and Angelo Michele Carella

JCO Aug 15 2003: 3177-a–3178. [Full Text] [PDF]

In Reply:

Bruce E. Hillner and Robert A. Kyle

JCO Aug 15 2003: 3178. [Full Text] [PDF]

What Do Global Quality-of-Life Questions Really Measure? Insights From Hobday et al and the "Do Something" Rule

David Cella

JCO Aug 15 2003: 3178-a–3179. [Full Text] [PDF]

In Reply:

Timothy Hobday, Jeff Sloan, and Richard Goldberg

JCO Aug 15 2003: 3179. [Full Text] [PDF]

The Predictive Role of HER2 Overexpression in Early Breast Cancer

Alfredo Tartarone, Gianpiero Romano, Giovanni Iodice, Alba Capobianco, and Nicola Di Renzo

JCO Aug 15 2003: 3179-a–3180. [Full Text] [PDF]

In Reply:

S. Menard, E. Biganzoli, P. Valagussa, P. Boracchi, and A. Moliterni

JCO Aug 15 2003: 3180. [Full Text] [PDF]

Errata

ERRATUM

JCO Aug 15 2003: 3181. [Full Text] [PDF]

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