EDITORIALS

Are Anthracycline-Taxane Regimens the New Standard of Care in the Treatment of Metastatic Breast Cancer?

Vicente Valero and Gabriel N. Hortobagyi

JCO Mar 15 2003: 959–962. [Full Text] [PDF]

Optimal Chemotherapy for Women With Breast Cancer: The Plot Thickens

Joseph L. Pater and Kathleen I. Pritchard

JCO Mar 15 2003: 963–964. First published on Feb 7 2003; 10.1200/JCO.2003.12.067. [Full Text] [PDF]

Lymph Node Dissection: Is It Diagnostic or Therapeutic?

Elin R. Sigurdson

JCO Mar 15 2003: 965–967. [Full Text] [PDF]

ORIGINAL REPORTS
Breast Cancer
	Docetaxel and Doxorubicin Compared With Doxorubicin and Cyclophosphamide as First-Line Chemotherapy for Metastatic Breast Cancer: Results of a Randomized, Multicenter, Phase III Trial
	Jean-Marc Nabholtz, Carla Falkson, Daniel Campos, Janos Szanto, Miguel Martin, Stephen Chan, Tadeuz Pienkowski, Jerzy Zaluski, Tamas Pinter, Maciej Krzakowski, Daniel Vorobiof, Robert Leonard, Ian Kennedy, Nacer Azli, Michael Murawsky, Alessandro Riva, and Pierre Pouillart
	JCO Mar 15 2003: 968–975. [Abstract] [Full Text] [PDF]
	Improved Outcomes From Adding Sequential Paclitaxel but Not From Escalating Doxorubicin Dose in an Adjuvant Chemotherapy Regimen for Patients With Node-Positive Primary Breast Cancer
	I. Craig Henderson, Donald A. Berry, George D. Demetri, Constance T. Cirrincione, Lori J. Goldstein, Silvana Martino, James N. Ingle, M. Robert Cooper, Daniel F. Hayes, Katherine H. Tkaczuk, Gini Fleming, James F. Holland, David B. Duggan, John T. Carpenter, Emil Frei, III, Richard L. Schilsky, William C. Wood, Hyman B. Muss, and Larry Norton
	JCO Mar 15 2003: 976–983. First published on Feb 7 2003; 10.1200/JCO.2003.02.063. [Abstract] [Full Text] [PDF]
	Randomized Trial of Tamoxifen Versus Tamoxifen Plus Aminoglutethimide as Adjuvant Treatment in Postmenopausal Breast Cancer Patients With Hormone Receptor-Positive Disease: Austrian Breast and Colorectal Cancer Study Group Trial 6
	Marianne Schmid, Raimund Jakesz, Hellmut Samonigg, Ernst Kubista, Michael Gnant, Christian Menzel, Michael Seifert, Karin Haider, Susanne Taucher, Brigitte Mlineritsch, Peter Steindorfer, Werner Kwasny, Michael Stierer, Christoph Tausch, Michael Fridrik, Viktor Wette, Günther Steger, and Hubert Hausmaninger
	JCO Mar 15 2003: 984–990. [Abstract] [Full Text] [PDF]
	Randomized Controlled Trial Comparing Oral Doxifluridine Plus Oral Cyclophosphamide With Doxifluridine Alone in Women With Node-Positive Breast Cancer After Primary Surgery
	Takeshi Tominaga, Hiroki Koyama, Tetsuya Toge, Shigeto Miura, Keizo Sugimachi, Susumu Yamaguchi, Koichi Hirata, Yasumasa Monden, Yasuo Nomura, Masakazu Toi, Izo Kimijima, Shinzaburo Noguchi, Hiroshi Sonoo, Kazuaki Asaishi, Tadashi Ikeda, Tadaoki Morimoto, Jun Ota, Yasuo Ohashi, and Osahiko Abe
	JCO Mar 15 2003: 991–998. [Abstract] [Full Text] [PDF]
	Multicenter Phase II Study of Oral Bexarotene for Patients With Metastatic Breast Cancer
	Francisco J. Esteva, John Glaspy, Said Baidas, Leslie Laufman, Laura Hutchins, Maura Dickler, Debu Tripathy, Roger Cohen, Angela DeMichele, Richard C. Yocum, C. Kent Osborne, Daniel F. Hayes, Gabriel N. Hortobagyi, Eric Winer, and George D. Demetri
	JCO Mar 15 2003: 999–1006. [Abstract] [Full Text] [PDF]
	Phase II, Randomized, Double-Blind Study of Two Dose Levels of Arzoxifene in Patients With Locally Advanced or Metastatic Breast Cancer
	Aman Buzdar, Joyce A. O’Shaughnessy, Daniel J. Booser, John E. Pippen, Jr., Stephen E. Jones, Pamela N. Munster, Patrick Peterson, Allen S. Melemed, Eric Winer, and Clifford Hudis
	JCO Mar 15 2003: 1007–1014. [Abstract] [Full Text] [PDF]
	Immunotherapy of Advanced Breast Cancer With a Heterophilic Ganglioside (NeuGcGM3) Cancer Vaccine
	Adriana Carr, Edmundo Rodríguez, María del Carmen Arango, Rolando Camacho, Marta Osorio, Mariano Gabri, Guido Carrillo, Zolidina Valdés, Yanín Bebelagua, Rolando Pérez, and Luis Enrique Fernández
	JCO Mar 15 2003: 1015–1021. [Abstract] [Full Text] [PDF]
	Invasion Factors uPA/PAI-1 and HER2 Status Provide Independent and Complementary Information on Patient Outcome in Node-Negative Breast Cancer
	Iris Zemzoum, Ronald E. Kates, Jeffrey S. Ross, Peer Dettmar, Moshumi Dutta, Cordula Henrichs, Suna Yurdseven, Heinz Höfler, Marion Kiechle, Manfred Schmitt, and Nadia Harbeck
	JCO Mar 15 2003: 1022–1028. [Abstract] [Full Text] [PDF]

Lung Cancer
	Effect of Number of Lymph Nodes Sampled on Outcome in Patients With Stage I Non–Small-Cell Lung Cancer
	Ajeet Gajra, Nancy Newman, Gary P. Gamble, Leslie J. Kohman, and Stephen L. Graziano
	JCO Mar 15 2003: 1029–1034. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	Human Kallikrein 6 (hK6): A New Potential Serum Biomarker for Diagnosis and Prognosis of Ovarian Carcinoma
	Eleftherios P. Diamandis, Andreas Scorilas, Stefano Fracchioli, Marleen van Gramberen, Henk de Bruijn, Alfthan Henrik, Antoninus Soosaipillai, Linda Grass, George M. Yousef, Ulf-Hakan Stenman, Marco Massobrio, Ate GJ van der Zee, Ignace Vergote, and Dionyssios Katsaros
	JCO Mar 15 2003: 1035–1043. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Treatment of Primary CNS Lymphoma With Methotrexate and Deferred Radiotherapy: A Report of NABTT 96–07
	Tracy Batchelor, Kathryn Carson, Alison O’Neill, Stuart A. Grossman, Jane Alavi, Pamela New, Fred Hochberg, and Regina Priet
	JCO Mar 15 2003: 1044–1049. [Abstract] [Full Text] [PDF]
	Randomized Phase I/II Study of Troxacitabine Combined With Cytarabine, Idarubicin, or Topotecan in Patients With Refractory Myeloid Leukemias
	Francis J. Giles, Stefan Faderl, Deborah A. Thomas, Jorge E. Cortes, Guillermo Garcia-Manero, Dan Douer, Alexandra M. Levine, Charles A. Koller, Sima S. Jeha, Susan M. O’Brien, Elihu H. Estey, and Hagop M. Kantarjian
	JCO Mar 15 2003: 1050–1056. [Abstract] [Full Text] [PDF]

Melanoma
	Clinical Outcome of Stage I/II Melanoma Patients After Selective Sentinel Lymph Node Dissection: Long-Term Follow-Up Results
	R.J.C.L.M. Vuylsteke, P.A.M. van Leeuwen, M.G. Statius Muller, H.A. Gietema, D.R. Kragt, and S. Meijer
	JCO Mar 15 2003: 1057–1065. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Regulatory Approvals of Pediatric Oncology Drugs: Previous Experience and New Initiatives
	Steven Hirschfeld, Peter T.C. Ho, Malcolm Smith, and Richard Pazdur
	JCO Mar 15 2003: 1066–1073. First published on Feb 7 2003; 10.1200/JCO.2003.11.138. [Abstract] [Full Text] [PDF]
	Risk of Secondary Leukemia After a Solid Tumor in Childhood According to the Dose of Epipodophyllotoxins and Anthracyclines: A Case-Control Study by the Société Française d’Oncologie Pédiatrique
	Marie-Cécile Le Deley, Thierry Leblanc, Akthar Shamsaldin, Marie-Anne Raquin, Brigitte Lacour, Danièle Sommelet, Agnès Chompret, Jean-Michel Cayuela, Chantal Bayle, Alain Bernheim, Florent de Vathaire, Gilles Vassal, and Catherine Hill
	JCO Mar 15 2003: 1074–1081. [Abstract] [Full Text] [PDF]
	Impact of Metaiodobenzylguanidine Scintigraphy on Assessing Response of High-Risk Neuroblastoma to Dose-Intensive Induction Chemotherapy
	Brian H. Kushner, Samuel D.J. Yeh, Kim Kramer, Steven M. Larson, and Nai-Kong V. Cheung
	JCO Mar 15 2003: 1082–1086. [Abstract] [Full Text] [PDF]
	Quantitation of GD2 Synthase mRNA by Real-Time Reverse Transcriptase Polymerase Chain Reaction: Clinical Utility in Evaluating Adjuvant Therapy in Neuroblastoma
	Irene Y. Cheung, M. Serena Lo Piccolo, Brian H. Kushner, Kim Kramer, and Nai-Kong V. Cheung
	JCO Mar 15 2003: 1087–1093. [Abstract] [Full Text] [PDF]

Radiation Oncology
	Early Detection of Response to Radiation Therapy in Patients With Brain Malignancies Using Conventional and High b-Value Diffusion-Weighted Magnetic Resonance Imaging
	Yael Mardor, Raphael Pfeffer, Roberto Spiegelmann, Yiftach Roth, Stephan E. Maier, Ouzi Nissim, Raanan Berger, Ami Glicksman, Jacob Baram, Arie Orenstein, Jack S. Cohen, and Thomas Tichler
	JCO Mar 15 2003: 1094–1100. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Radiotherapy for Stages IIA/B Testicular Seminoma: Final Report of a Prospective Multicenter Clinical Trial
	Johannes Classen, Heinz Schmidberger, Christoph Meisner, Rainer Souchon, Marie-Luise Sautter-Bihl, Rolf Sauer, Stefan Weinknecht, Kai-U. Köhrmann, and Michael Bamberg
	JCO Mar 15 2003: 1101–1106. [Abstract] [Full Text] [PDF]
	Quality of Life in Good Prognosis Patients With Metastatic Germ Cell Cancer: A Prospective Study of the European Organization for Research and Treatment of Cancer Genitourinary Group/Medical Research Council Testicular Cancer Study Group (30941/TE20)
	Sophie D. Fosså, Ronald de Wit, J. Trevor Roberts, Peter M. Wilkinson, Pieter H.M. de Mulder, Graham M. Mead, Pat Cook, Linda de Prijck, Sally Stenning, Neil K. Aaronson, Andrew Bottomley, and Laurence Collette
	JCO Mar 15 2003: 1107–1118. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Preoperative Concurrent Chemoradiotherapy in Locally Advanced Rectal Cancer With High-Dose Radiation and Oxaliplatin-Containing Regimen: The Lyon R0–04 Phase II Trial
	Jean-Pierre Gérard, Olivier Chapet, Chantal Nemoz, Pascale Romestaing, Françoise Mornex, Régis Coquard, Nicolas Barbet, Dan Atlan, Patrice Adeleine, and Gilles Freyer
	JCO Mar 15 2003: 1119–1124. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacokinetic Study of Intravenous Irinotecan Plus Oral Ciclosporin in Patients With Fluorouracil-Refractory Metastatic Colon Cancer
	John D. Chester, Simon P. Joel, Susan L. Cheeseman, Geoffrey D. Hall, Michael S. Braun, Jackie Perry, Theresa Davis, Christopher J. Button, and Matthew T. Seymour
	JCO Mar 15 2003: 1125–1132. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Identifying Potential Indicators of the Quality of End-of-Life Cancer Care From Administrative Data
	Craig C. Earle, Elyse R. Park, Bonnie Lai, Jane C. Weeks, John Z. Ayanian, and Susan Block
	JCO Mar 15 2003: 1133–1138. [Abstract] [Full Text] [PDF]
	Economic Evaluation of Breast Cancer Treatment: Considering the Value of Patient Choice
	Daniel Polsky, Jeanne S. Mandelblatt, Jane C. Weeks, Laura Venditti, Yi-Ting Hwang, Henry A. Glick, Jack Hadley, and Kevin A. Schulman
	JCO Mar 15 2003: 1139–1146. [Abstract] [Full Text] [PDF]
	General Quality of Life 2 Years Following Treatment for Prostate Cancer: What Influences Outcomes? Results From the Prostate Cancer Outcomes Study
	David F. Penson, Ziding Feng, Alan Kuniyuki, Dale McClerran, Peter C. Albertsen, Dennis Deapen, Frank Gilliland, Richard Hoffman, Robert A. Stephenson, Arnold L. Potosky, and Janet L. Stanford
	JCO Mar 15 2003: 1147–1154. [Abstract] [Full Text] [PDF]
	Maternal Preoccupation and Parenting as Predictors of Emotional and Behavioral Problems in Children of Women With Breast Cancer
	John J. Sigal, J. Christopher Perry, James M. Robbins, Marie-Anik Gagné, and Edgard Nassif
	JCO Mar 15 2003: 1155–1160. [Abstract] [Full Text] [PDF]
	Influenza Vaccination in Elderly Patients With Advanced Colorectal Cancer
	Craig C. Earle
	JCO Mar 15 2003: 1161–1166. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Phase I Clinical and Pharmacology Study of Clofarabine in Patients With Solid and Hematologic Cancers
	Hagop M. Kantarjian, Varsha Gandhi, Peter Kozuch, Stefan Faderl, Francis Giles, Jorge Cortes, Susan O’Brien, Nuhad Ibrahim, Fadlo Khuri, Min Du, Mary Beth Rios, Sima Jeha, Peter McLaughlin, William Plunkett, and Michael Keating
	JCO Mar 15 2003: 1167–1173. [Abstract] [Full Text] [PDF]

Biology of Neoplasia
	Role of DNA Mismatch Repair Defects in the Pathogenesis of Human Cancer
	Päivi Peltomäki
	JCO Mar 15 2003: 1174–1179. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Granulosa Cell Tumor of the Ovary
	Susan Tinsley Schumer and Stephen A. Cannistra
	JCO Mar 15 2003: 1180–1189. [Abstract] [Full Text] [PDF]

SPECIAL DEPARTMENTS

CORRESPONDENCE

Adjuvant Chemotherapy for Node-Positive Breast Cancer Patients: Which is the Reference Today?

Pierre Fumoleau, Jacques Bonneterre, and Elisabeth Luporsi

JCO Mar 15 2003: 1190–1191. [Full Text] [PDF]

In Reply:

Jean-Marc A. Nabholtz

JCO Mar 15 2003: 1191–1192. [Full Text] [PDF]

To the Editor

Henry Ekert and David Ashley

JCO Mar 15 2003: 1192. [Full Text] [PDF]

In Reply:

James Nachman

JCO Mar 15 2003: 1192-a. [Full Text] [PDF]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.