EDITORIALS

The Study of Accrual to Clinical Trials: Can We Learn From Studying Who Enters Our Studies?

Otis W. Brawley

JCO Jun 1 2004: 2039–2040. First published on Apr 13 2004; 10.1200/JCO.2004.02.926. [Full Text] [PDF]

The Debate Is Over; It's Time to Move On

Nicholas J. Petrelli

JCO Jun 1 2004: 2041–2042. First published on Apr 13 2004; 10.1200/JCO.2004.03.956. [Full Text] [PDF]

Chemotherapy for Melanoma: The Resultant of Conflicting Vectors

Malcolm S. Mitchell

JCO Jun 1 2004: 2043–2045. First published on May 3 2004; 10.1200/JCO.2004.03.976. [Full Text] [PDF]

ORIGINAL REPORTS
Breast Cancer
	Factors Associated With Breast Cancer Clinical Trials Participation and Enrollment at a Large Academic Medical Center
	Michael S. Simon, Wei Du, Lawrence Flaherty, Philip A. Philip, Patricia Lorusso, Cheryl Miree, Daryn Smith, and Diane R Brown
	JCO Jun 1 2004: 2046–2052. First published on Apr 13 2004; 10.1200/JCO.2004.03.005. [Abstract] [Full Text] [PDF]
	Signal Transducer and Activator of Transcription-5 Activation and Breast Cancer Prognosis
	Marja T. Nevalainen, Jianwu Xie, Joachim Torhorst, Lukas Bubendorf, Philippe Haas, Juha Kononen, Guido Sauter, and Hallgeir Rui
	JCO Jun 1 2004: 2053–2060. [Abstract] [Full Text] [PDF]
	Failure of Higher-Dose Paclitaxel to Improve Outcome in Patients With Metastatic Breast Cancer: Cancer and Leukemia Group B Trial 9342
	Eric P. Winer, Donald A. Berry, Susan Woolf, David Duggan, Alice Kornblith, Lyndsay N. Harris, Richard A. Michaelson, Jeffrey A. Kirshner, Gini F. Fleming, Michael C. Perry, Mark L. Graham, Stewart A. Sharp, Roger Keresztes, I. Craig Henderson, Clifford Hudis, Hyman Muss, and Larry Norton
	JCO Jun 1 2004: 2061–2068. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Extended Lymph Node Dissection for Gastric Cancer: Who May Benefit? Final Results of the Randomized Dutch Gastric Cancer Group Trial
	H.H. Hartgrink, C.J.H. van de Velde, H. Putter, J.J. Bonenkamp, E. Klein Kranenbarg, I. Songun, K. Welvaart, J.H.J.M. van Krieken, S. Meijer, J.T.M. Plukker, P.J. van Elk, H. Obertop, D.J. Gouma, J.J.B. van Lanschot, C.W. Taat, P.W. de Graaf, M.F. von Meyenfeldt, H. Tilanus, and M. Sasako
	JCO Jun 1 2004: 2069–2077. First published on Apr 13 2004; 10.1200/JCO.2004.08.026. [Abstract] [Full Text] [PDF]
	Phase II Study of Capecitabine in Patients With Fluorouracil-Resistant Metastatic Colorectal Carcinoma
	Paulo M. Hoff, Richard Pazdur, Yvonne Lassere, Susan Carter, Dvorit Samid, Diane Polito, and James L. Abbruzzese
	JCO Jun 1 2004: 2078–2083. [Abstract] [Full Text] [PDF]
	XELOX (Capecitabine Plus Oxaliplatin): Active First-Line Therapy for Patients With Metastatic Colorectal Cancer
	Jim Cassidy, Josep Tabernero, Chris Twelves, René Brunet, Charles Butts, Thierry Conroy, Filippo Debraud, Arie Figer, Johannes Grossmann, Noriaki Sawada, Patrick Schöffski, Alberto Sobrero, Eric Van Cutsem, and Eduardo Díaz-Rubio
	JCO Jun 1 2004: 2084–2091. [Abstract] [Full Text] [PDF]

Melanoma
	Exposure of Melanoma Cells to Dacarbazine Results in Enhanced Tumor Growth and Metastasis In Vivo
	Dina Chelouche Lev, Amir Onn, Vladislava O. Melinkova, Claudia Miller, Valerie Stone, Maribelis Ruiz, Eric C. McGary, Honnavara N. Ananthaswamy, Janet E. Price, and Menashe Bar-Eli
	JCO Jun 1 2004: 2092–2100. First published on May 3 2004; 10.1200/JCO.2004.11.070. [Abstract] [Full Text] [PDF]
	Temozolomide for the Treatment of Brain Metastases Associated With Metastatic Melanoma: A Phase II Study
	Sanjiv S. Agarwala, John M. Kirkwood, Martin Gore, Brigitte Dreno, Nicholas Thatcher, Beate Czarnetski, Michael Atkins, Antonio Buzaid, Dimosthenis Skarlos, and Elaine M. Rankin
	JCO Jun 1 2004: 2101–2107. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Phase I Trial of the Proteasome Inhibitor Bortezomib in Patients With Advanced Solid Tumors With Observations in Androgen-Independent Prostate Cancer
	Christos N. Papandreou, Danai D. Daliani, Darrell Nix, Hong Yang, Timothy Madden, Xuemei Wang, Christine S. Pien, Randall E. Millikan, Shi-Ming Tu, Lance Pagliaro, Jeri Kim, Julian Adams, Peter Elliott, Dixie Esseltine, Alexandria Petrusich, Pauline Dieringer, Cherie Perez, and Christopher J. Logothetis
	JCO Jun 1 2004: 2108–2121. [Abstract] [Full Text] [PDF]
	Phase II Randomized Study of Vaccine Treatment of Advanced Prostate Cancer (E7897): A Trial of the Eastern Cooperative Oncology Group
	Howard L. Kaufman, Wei Wang, Judith Manola, Robert S. DiPaola, Yoo-Joung Ko, Christopher Sweeney, Theresa L. Whiteside, Jeffrey Schlom, George Wilding, and Louis M. Weiner
	JCO Jun 1 2004: 2122–2132. [Abstract] [Full Text] [PDF]
	Ki-67 Staining Is a Strong Predictor of Distant Metastasis and Mortality for Men With Prostate Cancer Treated With Radiotherapy Plus Androgen Deprivation: Radiation Therapy Oncology Group Trial 92–02
	A. Pollack, M. DeSilvio, L.-Y. Khor, R. Li, T.I. Al-Saleem, M.E. Hammond, V. Venkatesan, C.A. Lawton, M. Roach, III, W.U. Shipley, G.E. Hanks, and H.M. Sandler
	JCO Jun 1 2004: 2133–2140. [Abstract] [Full Text] [PDF]
	The Changing Face of Low-Risk Prostate Cancer: Trends in Clinical Presentation and Primary Management
	Matthew R. Cooperberg, Deborah P. Lubeck, Maxwell V. Meng, Shilpa S. Mehta, and Peter R. Carroll
	JCO Jun 1 2004: 2141–2149. [Abstract] [Full Text] [PDF]
	Adjuvant Chemotherapy With Paclitaxel and Carboplatin in Patients With Advanced Carcinoma of the Upper Urinary Tract: A Study by the Hellenic Cooperative Oncology Group
	A. Bamias, Ch. Deliveliotis, G. Fountzilas, D. Gika, A. Anagnostopoulos, M.P. Zorzou, E. Kastritis, C. Constantinides, P. Kosmidis, and M.A. Dimopoulos
	JCO Jun 1 2004: 2150–2154. [Abstract] [Full Text] [PDF]

Treatment-related Complications
	Secondary Leukemias in Refractory Germ Cell Tumor Patients Undergoing Autologous Stem-Cell Transplantation Using High-Dose Etoposide
	William Houck, Rafat Abonour, Gail Vance, and Lawrence H. Einhorn
	JCO Jun 1 2004: 2155–2158. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	Phase III Trial of Doxorubicin Plus Cisplatin With or Without Paclitaxel Plus Filgrastim in Advanced Endometrial Carcinoma: A Gynecologic Oncology Group Study
	Gini F. Fleming, Virginia L. Brunetto, David Cella, Katherine Y. Look, Gary C. Reid, Adnan R. Munkarah, Richard Kline, Robert A. Burger, Annekathryn Goodman, and R. Tucker Burks
	JCO Jun 1 2004: 2159–2166. [Abstract] [Full Text] [PDF]
	Posttherapy [18F] Fluorodeoxyglucose Positron Emission Tomography in Carcinoma of the Cervix: Response and Outcome
	Perry W. Grigsby, Barry A. Siegel, Farrokh Dehdashti, Janet Rader, and Imran Zoberi
	JCO Jun 1 2004: 2167–2171. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Graft-Versus-Lymphoma Effect in Relapsed Peripheral T-Cell Non-Hodgkin's Lymphomas After Reduced-Intensity Conditioning Followed by Allogeneic Transplantation of Hematopoietic Cells
	Paolo Corradini, Anna Dodero, Francesco Zallio, Daniele Caracciolo, Marco Casini, Marco Bregni, Franco Narni, Francesca Patriarca, Mario Boccadoro, Fabio Benedetti, A. Rambaldi, Alessandro M. Gianni, and Corrado Tarella
	JCO Jun 1 2004: 2172–2176. [Abstract] [Full Text] [PDF]

Aids-Related Cancer
	Antiretroviral Treatment Regimens and Immune Parameters in the Prevention of Systemic AIDS-Related Non-Hodgkin's Lymphoma
	Justin Stebbing, Brian Gazzard, Sundhiya Mandalia, Alastair Teague, Ashita Waterston, Vanessa Marvin, Mark Nelson, and Mark Bower
	JCO Jun 1 2004: 2177–2183. [Abstract] [Full Text] [PDF]

Lung Cancer
	Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer
	David H. Johnson, Louis Fehrenbacher, William F. Novotny, Roy S. Herbst, John J. Nemunaitis, David M. Jablons, Corey J. Langer, Russell F. DeVore, III, Jacques Gaudreault, Lisa A. Damico, Eric Holmgren, and Fairooz Kabbinavar
	JCO Jun 1 2004: 2184–2191. [Abstract] [Full Text] [PDF]
	Phase II Trial of Pleural Photodynamic Therapy and Surgery for Patients With Non–Small-Cell Lung Cancer With Pleural Spread
	Joseph S. Friedberg, Rosemarie Mick, James P. Stevenson, Timothy Zhu, Theresa M. Busch, Daniel Shin, Debbie Smith, Melissa Culligan, Andreea Dimofte, Eli Glatstein, and Stephen M. Hahn
	JCO Jun 1 2004: 2192–2201. [Abstract] [Full Text] [PDF]
	Estimate of Lung Cancer Mortality From Low-Dose Spiral Computed Tomography Screening Trials: Implications for Current Mass Screening Recommendations
	Edward F. Patz, Jr, Stephen J. Swensen, and James E. Herndon, II
	JCO Jun 1 2004: 2202–2206. [Abstract] [Full Text] [PDF]

Radiation Oncology
	Pentoxifylline in the Treatment of Radiation-Induced Fibrosis
	Paul Okunieff, Elizabeth Augustine, Jeanne E. Hicks, Terri L. Cornelison, Rosemary M. Altemus, Boris G. Naydich, Ivan Ding, Amy K. Huser, Edward H. Abraham, Judith J. Smith, Norman Coleman, and Lynn H. Gerber
	JCO Jun 1 2004: 2207–2213. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	Four Decades of Continuing Innovation With Fluorouracil: Current and Future Approaches to Fluorouracil Chemoradiation Therapy
	Tyvin A. Rich, Robert C. Shepard, and Stephen T. Mosley
	JCO Jun 1 2004: 2214–2232. [Abstract] [Full Text] [PDF]

SPECIAL ARTICLE
	Cognitive Impairment Associated With Chemotherapy for Cancer: Report of a Workshop
	Ian F. Tannock, Tim A. Ahles, Patricia A. Ganz, and Frits S. van Dam
	JCO Jun 1 2004: 2233–2239. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Paraneoplastic Syndromes in Cancer: CASE 1. Polycythemia As a Result of Ectopic Erythropoietin Production in Metastatic Pancreatic Carcinoid Tumor

I. Samyn, C. Fontaine, F. Van Tussenbroek, M. Pipeleers-Marichal, and J. De Grève

JCO Jun 1 2004: 2240–2242. [Full Text] [PDF]

Paraneoplastic Syndromes in Cancer: CASE 2. Leucocytosis Associated With Liposarcoma Recurrence: Original Presentation of Liposarcoma Recurrence

Gaëtan des Guetz, Pascale Mariani, Paul Freneaux, and Pierre Pouillart

JCO Jun 1 2004: 2242–2243. [Full Text] [PDF]

Paraneoplastic Syndromes in Cancer: CASE 3. Parathyroid Hormone-Related Hypercalcemia in Cholangiocarcinoma

Yun Yen, Peiguo G. Chu, and Wei Feng

JCO Jun 1 2004: 2244–2245. [Full Text] [PDF]

ART OF ONCOLOGY

Real-Time Rationing of Scarce Resources: The Northeast Proton Therapy Center Experience

Reshma Jagsi, Thomas F. DeLaney, Karen Donelan, and Nancy J. Tarbell

JCO Jun 1 2004: 2246–2250. [Full Text] [PDF]

SPECIAL DEPARTMENTS

Correspondence

What ASCO Does for Its Members

Denis B. Hammond

JCO Jun 1 2004: 2251–2252. [Full Text] [PDF]

Concurrence of Germline Mutations in the APC and PTEN Genes in a Colonic Polyposis Family Member

L. Valle, R. Rodríguez-López, M. Robledo, J. Benítez, and M. Urioste

JCO Jun 1 2004: 2252–2253. [Full Text] [PDF]

Cavernosal Arterial Insufficiency and Metabolic Syndrome Probably Represent a Common Pathology of Endothelial Dysfunction in Recipients of High-Dose Therapy and Stem-Cell Transplantation

Ratna Chatterjee, Katerina Palla, and Panagiotis D. Kottaridis

JCO Jun 1 2004: 2253–2254. [Full Text] [PDF]

Uncertainties Regarding Pelvic Radiotherapy for Prostate Cancer

Ronald D. Ennis

JCO Jun 1 2004: 2254–2255. [Full Text] [PDF]

In Reply:

Mack Roach, III

JCO Jun 1 2004: 2255–2257. [Full Text] [PDF]

Internal Mammary Lymphatic Irradiation: To Be or Not to Be?

Mustafa Cengiz

JCO Jun 1 2004: 2257–2258. [Full Text] [PDF]

In Reply:

Salomon M. Stemmer and M. Raphael Pfeffer

JCO Jun 1 2004: 2258. [Full Text] [PDF]

Empathy in the Doctor-Patient Relationship

Maura Anfossi and Gianmauro Numico

JCO Jun 1 2004: 2258-a–2259. [Full Text]

In Reply:

David N. Korones

JCO Jun 1 2004: 2259–2260. [Full Text] [PDF]

Erratum

ERRATUM

JCO Jun 1 2004: 2261. [Full Text] [PDF]

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