EDITORIALS

What Is the Role of High-Dose Chemotherapy in the Era of Targeted Therapies?

Gabriel N. Hortobagyi

JCO Jun 15 2004: 2263–2266. First published on Apr 26 2004; 10.1200/JCO.2004.02.927. [Full Text] [PDF]

Trawling for Genes That Predict Response to Breast Cancer Adjuvant Therapy

Matthew Ellis and Karla Ballman

JCO Jun 15 2004: 2267–2269. First published on May 10 2004; 10.1200/JCO.2004.03.950. [Full Text] [PDF]

New Target, New Drug, Old Paradigm

Manuel Hidalgo

JCO Jun 15 2004: 2270–2272. First published on May 10 2004; 10.1200/JCO.2004.03.918. [Full Text] [PDF]

ORIGINAL REPORTS
Breast Cancer
	High-Dose Chemotherapy With Autologous Hematopoietic Stem-Cell Support Compared With Standard-Dose Chemotherapy in Breast Cancer Patients With 10 or More Positive Lymph Nodes: First Results of a Randomized Trial
	A.R. Zander, N. Kröger, C. Schmoor, W. Krüger, V. Möbus, N. Frickhofen, B. Metzner, W. Schultze, W.E. Berdel, M. Koenigsmann, E. Thiel, H. Wandt, K. Possinger, L. Trümper, R. Kreienberg, M. Carstensen, E.H. Schmidt, F. Jänicke, M. Schumacher, and W. Jonat
	JCO Jun 15 2004: 2273–2283. First published on Apr 26 2004; 10.1200/JCO.2004.07.026. [Abstract] [Full Text] [PDF]
	Gene Expression Profiles Predict Complete Pathologic Response to Neoadjuvant Paclitaxel and Fluorouracil, Doxorubicin, and Cyclophosphamide Chemotherapy in Breast Cancer
	M. Ayers, W.F. Symmans, J. Stec, A.I. Damokosh, E. Clark, K. Hess, M. Lecocke, J. Metivier, D. Booser, N. Ibrahim, V. Valero, M. Royce, B. Arun, G. Whitman, J. Ross, N. Sneige, G.N. Hortobagyi, and L. Pusztai
	JCO Jun 15 2004: 2284–2293. First published on May 10 2004; 10.1200/JCO.2004.05.166. [Abstract] [Full Text] [PDF]
	The Use of Alternate, Non–Cross-Resistant Adjuvant Chemotherapy on the Basis of Pathologic Response to a Neoadjuvant Doxorubicin-Based Regimen in Women With Operable Breast Cancer: Long-Term Results From a Prospective Randomized Trial
	Eva Thomas, Frankie A. Holmes, Terry L. Smith, Aman U. Buzdar, Debra K. Frye, Giuseppe Fraschini, S. Eva Singletary, Richard L. Theriault, Marsha D. McNeese, Frederick Ames, Ronald Walters, and Gabriel N. Hortobagyi
	JCO Jun 15 2004: 2294–2302. [Abstract] [Full Text] [PDF]
	Breast Conservation After Neoadjuvant Chemotherapy: The M.D. Anderson Cancer Center Experience
	Allen M. Chen, Funda Meric-Bernstam, Kelly K. Hunt, Howard D. Thames, Mary Jane Oswald, Elesyia D. Outlaw, Eric A. Strom, Marsha D. McNeese, Henry M. Kuerer, Merrick I. Ross, S. Eva Singletary, Fredrick C. Ames, Barry W. Feig, Aysegul A. Sahin, George H. Perkins, Naomi R. Schechter, Gabriel N. Hortobagyi, and Thomas A. Buchholz
	JCO Jun 15 2004: 2303–2312. [Abstract] [Full Text] [PDF]
	Phase III Study of Intravenous Vinorelbine in Combination With Epirubicin Versus Epirubicin Alone in Patients With Advanced Breast Cancer: A Scandinavian Breast Group Trial (SBG9403)
	Bent Ejlertsen, Henning T. Mouridsen, Sven T. Langkjer, Jorn Andersen, Johanna Sjöström, and Mogens Kjaer
	JCO Jun 15 2004: 2313–2320. [Abstract] [Full Text] [PDF]
	Capecitabine Plus Paclitaxel As Front-Line Combination Therapy for Metastatic Breast Cancer: A Multicenter Phase II Study
	William J. Gradishar, Luis A. Meza, Bipinkumar Amin, Dvorit Samid, Todd Hill, Yin-Miao Chen, Elyse E. Lower, and P. Kelly Marcom
	JCO Jun 15 2004: 2321–2327. [Abstract] [Full Text] [PDF]
	Contralateral Breast Cancer in BRCA1 and BRCA2 Mutation Carriers
	Kelly Metcalfe, Henry T. Lynch, Parviz Ghadirian, Nadine Tung, Ivo Olivotto, Ellen Warner, Olufunmilayo I. Olopade, Andrea Eisen, Barbara Weber, Jane McLennan, Ping Sun, William D. Foulkes, and Steven A. Narod
	JCO Jun 15 2004: 2328–2335. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Safety and Pharmacokinetics of Escalated Doses of Weekly Intravenous Infusion of CCI-779, a Novel mTOR Inhibitor, in Patients With Cancer
	Eric Raymond, Jérôme Alexandre, Sandrine Faivre, Karina Vera, Eric Materman, Joseph Boni, Cathie Leister, Joan Korth-Bradley, Axel Hanauske, and Jean-Pierre Armand
	JCO Jun 15 2004: 2336–2347. First published on May 10 2004; 10.1200/JCO.2004.08.116. [Abstract] [Full Text] [PDF]

Lung Cancer
	Randomized Phase III Study of Gemcitabine and Vinorelbine Versus Gemcitabine, Vinorelbine, and Cisplatin in the Treatment of Advanced Non-Small-Cell Lung Cancer: From the German and Swiss Lung Cancer Study Group
	E. Laack, N. Dickgreber, T. Müller, A. Knuth, J. Benk, C. Lorenz, F. Gieseler, H. Dürk, W. Engel-Riedel, K. Dalhoff, C. Kortsik, U. Graeven, M. Burk, T. Dierlamm, T. Welte, I. Burkholder, L. Edler, and D.K. Hossfeld
	JCO Jun 15 2004: 2348–2356. [Abstract] [Full Text] [PDF]
	Randomized Controlled Trial of the Role of Positron Emission Tomography in the Management of Stage I and II Non-Small-Cell Lung Cancer
	Rosalie C. Viney, Michael J. Boyer, Madeleine T. King, Patricia M. Kenny, Christine A. Pollicino, Jocelyn M. McLean, Brian C. McCaughan, and Michael J. Fulham
	JCO Jun 15 2004: 2357–2362. [Abstract] [Full Text] [PDF]
	Tumor-Specific Methylation in Bronchial Lavage for the Early Detection of Non-Small-Cell Lung Cancer
	Hojoong Kim, Young Mi Kwon, Jin Seuk Kim, Haengbyoung Lee, Jung-Ho Park, Young Mog Shim, Joungho Han, Joobae Park, and Duk-Hwan Kim
	JCO Jun 15 2004: 2363–2370. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Interleukin-6, Interleukin-10, and Vascular Endothelial Growth Factor in Metastatic Renal Cell Carcinoma: Prognostic Value of Interleukin-6—From the Groupe Français d'Immunothérapie
	Sylvie Negrier, David Perol, Christine Menetrier-Caux, Bernard Escudier, Michel Pallardy, Alain Ravaud, Jean-Yves Douillard, Christine Chevreau, Christine Lasset, and Jean-Yves Blay
	JCO Jun 15 2004: 2371–2378. [Abstract] [Full Text] [PDF]

Prevention
	Effects of a High-Fiber, Low-Fat Diet Intervention on Serum Concentrations of Reproductive Steroid Hormones in Women With a History of Breast Cancer
	Cheryl L. Rock, Shirley W. Flatt, Cynthia A. Thomson, Marcia L. Stefanick, Vicky A. Newman, Lovell A. Jones, Loki Natarajan, Cheryl Ritenbaugh, Kathryn A. Hollenbach, John P. Pierce, and R. Jeffrey Chang
	JCO Jun 15 2004: 2379–2387. [Abstract] [Full Text] [PDF]

Epidemiology
	The Risk of Cancer in Users of Statins
	Matthijs R. Graaf, Annette B. Beiderbeck, Antoine C.G. Egberts, Dick J. Richel, and Henk-Jan Guchelaar
	JCO Jun 15 2004: 2388–2394. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Multivariate Prognostic Factor Analysis in Locally Advanced and Metastatic Esophago-Gastric Cancer—Pooled Analysis From Three Multicenter, Randomized, Controlled Trials Using Individual Patient Data
	Ian Chau, Andy R. Norman, David Cunningham, Justin S. Waters, Jacqui Oates, and Paul J. Ross
	JCO Jun 15 2004: 2395–2403. [Abstract] [Full Text] [PDF]
	Improved Sphincter Preservation in Low Rectal Cancer With High-Dose Preoperative Radiotherapy: The Lyon R96-02 Randomized Trial
	Jean-Pierre Gerard, Olivier Chapet, Chantal Nemoz, Johannes Hartweig, Pascale Romestaing, Regis Coquard, Nicolas Barbet, Philippe Maingon, Marc Mahe, Jacques Baulieux, Christian Partensky, Marc Papillon, Olivier Glehen, Bruno Crozet, Jean-Paul Grandjean, and Patrice Adeleine
	JCO Jun 15 2004: 2404–2409. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Abnormal Cytogenetics at Date of Morphologic Complete Remission Predicts Short Overall and Disease-Free Survival, and Higher Relapse Rate in Adult Acute Myeloid Leukemia: Results From Cancer and Leukemia Group B Study 8461
	Guido Marcucci, Krzysztof Mrózek, Amy S. Ruppert, Kellie J. Archer, Mark J. Pettenati, Nyla A. Heerema, Andrew J. Carroll, Prasad R.K. Koduru, Jonathan E. Kolitz, Lisa J. Sterling, Colin G. Edwards, John Anastasi, Richard A. Larson, and Clara D. Bloomfield
	JCO Jun 15 2004: 2410–2418. [Abstract] [Full Text] [PDF]
	Nonmyeloablative Allogeneic Hematopoietic Transplantation: A Promising Salvage Therapy for Patients With Non-Hodgkin's Lymphoma Whose Disease Has Failed a Prior Autologous Transplantation
	Maricer P. Escalón, Richard E. Champlin, Rima M. Saliba, Sandra A. Acholonu, Chitra Hosing, Luis Fayad, Sergio Giralt, Naoto T. Ueno, Farzaneh Maadani, Barbara Pro, Michele Donato, Peter McLaughlin, and Issa F. Khouri
	JCO Jun 15 2004: 2419–2423. [Abstract] [Full Text] [PDF]
	Severe Pulmonary Toxicity in Patients With Advanced-Stage Hodgkin's Disease Treated With a Modified Bleomycin, Doxorubicin, Cyclophosphamide, Vincristine, Procarbazine, Prednisone, and Gemcitabine (BEACOPP) Regimen Is Probably Related to the Combination of Gemcitabine and Bleomycin: A Report of the German Hodgkin's Lymphoma Study Group
	Henning Bredenfeld, Jeremy Franklin, Lucia Nogova, Andreas Josting, S. Fries, Volker Mailänder, Joachim Oertel, Volker Diehl, and Andreas Engert
	JCO Jun 15 2004: 2424–2429. First published on May 10 2004; 10.1200/JCO.2004.09.114. [Abstract] [Full Text] [PDF]

Surgical Oncology
	Cost Minimization Study of Image-Guided Core Biopsy Versus Surgical Excisional Biopsy for Women With Abnormal Mammograms
	Robert M. Golub, Charles L. Bennett, Tammy Stinson, Luz Venta, and Monica Morrow
	JCO Jun 15 2004: 2430–2437. [Abstract] [Full Text] [PDF]

Melanoma
	Screening for Metastasis From Choroidal Melanoma: The Collaborative Ocular Melanoma Study Group Report 23
	Marie Diener-West, Sandra M. Reynolds, Donna J. Agugliaro, Robert Caldwell, Kristi Cumming, John D. Earle, Donna L. Green, Barbara S. Hawkins, James Hayman, Ishmael Jaiyesimi, John M. Kirkwood, Wui-Jin Koh, Dennis M. Robertson, John M. Shaw, and Jonni Thoma
	JCO Jun 15 2004: 2438–2444. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Phase I Trial and Pharmacokinetics of Gemcitabine in Children With Advanced Solid Tumors
	Joel M. Reid, Wenchun Qu, Stephanie L. Safgren, Matthew M. Ames, Mark D. Krailo, Nita L. Seibel, John Kuttesch, and John Holcenberg
	JCO Jun 15 2004: 2445–2451. [Abstract] [Full Text] [PDF]
	Hematologic Toxicity of High-Dose Iodine-131–Metaiodobenzylguanidine Therapy for Advanced Neuroblastoma
	Steven G. DuBois, Julia Messina, John M. Maris, John Huberty, David V. Glidden, Janet Veatch, Martin Charron, Randall Hawkins, and Katherine K. Matthay
	JCO Jun 15 2004: 2452–2460. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Determining the Relationship Between Toxicity and Quality of Life in an Ovarian Cancer Chemotherapy Clinical Trial
	Lorna Butler, Monica Bacon, Mark Carey, Benny Zee, Dongsheng Tu, and Andrea Bezjak
	JCO Jun 15 2004: 2461–2468. [Abstract] [Full Text] [PDF]
	An Eicosapentaenoic Acid Supplement Versus Megestrol Acetate Versus Both for Patients With Cancer-Associated Wasting: A North Central Cancer Treatment Group and National Cancer Institute of Canada Collaborative Effort
	Aminah Jatoi, Kendrith Rowland, Charles L. Loprinzi, Jeff A. Sloan, Shaker R. Dakhil, Neil MacDonald, Bruno Gagnon, Paul J. Novotny, James A. Mailliard, Teresita I.L. Bushey, Suresh Nair, and Brad Christensen
	JCO Jun 15 2004: 2469–2476. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Thalidomide: Current Role in the Treatment of Non-Plasma Cell Malignancies
	Shaji Kumar, Thomas E. Witzig, and S. Vincent Rajkumar
	JCO Jun 15 2004: 2477–2488. [Abstract] [Full Text] [PDF]
	Herbal Remedies in the United States: Potential Adverse Interactions With Anticancer Agents
	Alex Sparreboom, Michael C. Cox, Milin R. Acharya, and William D. Figg
	JCO Jun 15 2004: 2489–2503. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Side Effects of Therapy: CASE 1. Nephrotic Syndrome Associated With Gefitinib Therapy

Ryuichiro Kumasaka, Norio Nakamura, Kenichi Shirato, Hiroshi Osawa, Shingo Takanashi, Yukihiro Hasegawa, Hideaki Yamabe, Masayuki Nakamura, Michiko Tamura, and Ken Okumura

JCO Jun 15 2004: 2504–2505. [Full Text] [PDF]

Side Effects of Therapy: CASE 2. Tamoxifen and Uterine Abnormalities

C. Buijs, P.H.B. Willemse, D.J. Tinga, H. Hollema, E.G. de Vries, and M.J.E. Mourits

JCO Jun 15 2004: 2505–2507. [Full Text] [PDF]

Side Effects of Therapy: CASE 3. Gastric Cancer After Radiotherapy of Pediatric Hodgkin's Disease

J. Alexander Palesty, Wei Wang, Milind M. Javle, and Gary Y. Yang

JCO Jun 15 2004: 2507–2509. [Full Text] [PDF]

SPECIAL DEPARTMENTS

Correspondence

Prognosis in Therapy-Related Acute Myeloid Leukemia and Impact of Karyotype

Wolfgang Kern, Torsten Haferlach, Susanne Schnittger, Wolfgang Hiddemann, and Claudia Schoch

JCO Jun 15 2004: 2510–2511. [Full Text] [PDF]

Surgical Expertise and Outcome in Osteosarcoma Trials

Stefan S. Bielack and Heribert Jürgens

JCO Jun 15 2004: 2511. [Full Text] [PDF]

In Reply:

G. Bacci, A. Longhi, C. Forni, P. Ruggieri, A. Briccoli, M. De Paolis, and E. Setola

JCO Jun 15 2004: 2511-a–2513. [Full Text] [PDF]

Pathologic Complete Response and Survival Advantage in Esophageal Cancer: Old News

Michael J. Kraut

JCO Jun 15 2004: 2513. [Full Text] [PDF]

In Reply:

Alan G. Casson, S. Jane Darnton, Venice Archer, David Ferry, Deborah Stocken, and Paul Mulholland

JCO Jun 15 2004: 2513-a–2514. [Full Text] [PDF]

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