EDITORIALS

TNFerade to the Rescue? Guidelines for Evaluating Phase I Cancer Gene Transfer Trials

Steven M. Albelda and Daniel H. Sterman

JCO Feb 15 2004: 577–579. First published on Jan 15 2004; 10.1200/JCO.2004.12.964. [Full Text] [PDF]

Temozolomide for Melanoma: New Toxicities and New Opportunities

Thomas F. Gajewski

JCO Feb 15 2004: 580–581. First published on Jan 15 2004; 10.1200/JCO.2004.11.957. [Full Text] [PDF]

Loss of C/EBP and Favorable Prognosis of Acute Myeloid Leukemias: A Biological Paradox

Danilo Perrotti, Guido Marcucci, and Michael A. Caligiuri

JCO Feb 15 2004: 582–584. First published on Jan 15 2004; 10.1200/JCO.2004.12.965. [Full Text] [PDF]

Radiotherapy in Stage I Seminoma of the Testis

Alan Horwich

JCO Feb 15 2004: 585–588. First published on Jan 15 2004; 10.1200/JCO.2004.12.966. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

Hypofractionation Redux?

Thomas E. Goffman and Eli Glatstein

JCO Feb 15 2004: 589–591. [Full Text] [PDF]

ORIGINAL REPORTS
Phase I and Clinical Pharmacology
	TNFerade Biologic, an Adenovector With a Radiation-Inducible Promoter, Carrying the Human Tumor Necrosis Factor Alpha Gene: A Phase I Study in Patients With Solid Tumors
	Neil Senzer, Sridhar Mani, Alexander Rosemurgy, John Nemunaitis, Casey Cunningham, Chandan Guha, Natalia Bayol, Michelle Gillen, Karen Chu, Camilla Rasmussen, Henrik Rasmussen, Donald Kufe, Ralph Weichselbaum, and Nader Hanna
	JCO Feb 15 2004: 592–601. First published on Jan 15 2004; 10.1200/JCO.2004.01.227. [Abstract] [Full Text] [PDF]
	Individualized Patient Dosing in Phase I Clinical Trials: The Role of Escalation With Overdose Control in PNU-214936
	Jonathan D. Cheng, James S. Babb, Corey Langer, Steinar Aamdal, Francisco Robert, Lars Rupert Engelhardt, Olov Fernberg, Joan Schiller, Goran Forsberg, R. Katherine Alpaugh, Louis M. Weiner, and André Rogatko
	JCO Feb 15 2004: 602–609. [Abstract] [Full Text] [PDF]

Melanoma
	Selective CD4+ Lymphopenia in Melanoma Patients Treated With Temozolomide: A Toxicity With Therapeutic Implications
	Y.B. Su, Sejean Sohn, Susan E. Krown, Philip O. Livingston, Jedd D. Wolchok, Carolyn Quinn, Linda Williams, Theresa Foster, Kent A. Sepkowitz, and Paul B. Chapman
	JCO Feb 15 2004: 610–616. First published on Jan 15 2004; 10.1200/JCO.2004.07.060. [Abstract] [Full Text] [PDF]
	NF-B in the Vascular Progression of Melanoma
	Mohammed Kashani-Sabet, Ladan Shaikh, James R. Miller, III, Mehdi Nosrati, Carlos M.M. Ferreira, Robert J. Debs, and Richard W. Sagebiel
	JCO Feb 15 2004: 617–623. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	CEBPA Mutations in Younger Adults With Acute Myeloid Leukemia and Normal Cytogenetics: Prognostic Relevance and Analysis of Cooperating Mutations
	Stefan Fröhling, Richard F. Schlenk, Ina Stolze, Jörg Bihlmayr, Axel Benner, Sylvia Kreitmeier, Karen Tobis, Hartmut Döhner, and Konstanze Döhner
	JCO Feb 15 2004: 624–633. First published on Jan 15 2004; 10.1200/JCO.2004.06.060. [Abstract] [Full Text] [PDF]
	Primary Cutaneous B-Cell Lymphoma Treated With Radiotherapy: A Comparison of the European Organization for Research and Treatment of Cancer and the WHO Classification Systems
	Benjamin D. Smith, Earl J. Glusac, Jennifer M. McNiff, Grace L. Smith, Peter W. Heald, Dennis L. Cooper, and Lynn D. Wilson
	JCO Feb 15 2004: 634–639. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Mortality After Cure of Testicular Seminoma
	Gunar K. Zagars, Matthew T. Ballo, Andrew K. Lee, and Sara S. Strom
	JCO Feb 15 2004: 640–647. First published on Jan 15 2004; 10.1200/JCO.2004.05.205. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Impact of Body Mass Index on Outcomes and Treatment-Related Toxicity in Patients With Stage II and III Rectal Cancer: Findings From Intergroup Trial 0114
	Jeffrey A. Meyerhardt, Joel E. Tepper, Donna Niedzwiecki, Donna R. Hollis, A. David McCollum, Denise Brady, Michael J. O'Connell, Robert J. Mayer, Bernard Cummings, Christopher Willett, John S. Macdonald, Al B. Benson, III, and Charles S. Fuchs
	JCO Feb 15 2004: 648–657. [Abstract] [Full Text] [PDF]
	Phase II Trial of Biweekly Infusional Fluorouracil, Folinic Acid, and Oxaliplatin in Patients With Advanced Gastric Cancer
	Salah-Eddin Al-Batran, Akin Atmaca, Susanna Hegewisch-Becker, Dirk Jaeger, Sabine Hahnfeld, Mathias J Rummel, Gernot Seipelt, Andreas Rost, Jacqueline Orth, Alexander Knuth, and Elke Jaeger
	JCO Feb 15 2004: 658–663. [Abstract] [Full Text] [PDF]
	EBV-Positive Gastric Adenocarcinomas: A Distinct Clinicopathologic Entity With a Low Frequency of Lymph Node Involvement
	Josine van Beek, Axel zur Hausen, Elma Klein Kranenbarg, Cornelis J.H. van de Velde, Jaap M. Middeldorp, Adriaan J.C. van den Brule, Chris J.L.M. Meijer, and Elisabeth Bloemena
	JCO Feb 15 2004: 664–670. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	An Assessment of the Utilization of Complementary and Alternative Medication in Women With Gynecologic or Breast Malignancies
	Marisa A. Navo, Julie Phan, Christy Vaughan, J. Lynn Palmer, Laura Michaud, Kellie L. Jones, Diane C. Bodurka, Karen Basen-Engquist, Gabriel N. Hortobagyi, John J. Kavanagh, and Judith A. Smith
	JCO Feb 15 2004: 671–677. [Abstract] [Full Text] [PDF]
	Human Kallikrein 13 Protein in Ovarian Cancer Cytosols: A New Favorable Prognostic Marker
	Andreas Scorilas, Carla A. Borgoño, Nadia Harbeck, Julia Dorn, Barbara Schmalfeldt, Manfred Schmitt, and Eleftherios P. Diamandis
	JCO Feb 15 2004: 678–685. [Abstract] [Full Text] [PDF]
	Paclitaxel 175 or 225 mg per Meters Squared With Carboplatin in Advanced Ovarian Cancer: A Randomized Trial
	Giorgio Bolis, Giovanna Scarfone, Gianpiero Polverino, Francesco Raspagliesi, Saverio Tateo, Giovanni Richiardi, Mauro Melpignano, Massimo Franchi, Giorgia Mangili, Mauro Presti, Antonella Villa, Enrico Conta, Paolo Guarnerio, Sonia Cipriani, and Fabio Parazzini
	JCO Feb 15 2004: 686–690. [Abstract] [Full Text] [PDF]

Breast Cancer
	Mammaglobin Is Associated With Low-Grade, Steroid Receptor-Positive Breast Tumors From Postmenopausal Patients, and Has Independent Prognostic Value for Relapse-Free Survival Time
	Paul N. Span, Esmé Waanders, Peggy Manders, Joop J.T.M. Heuvel, John A. Foekens, Mark A. Watson, Louk V.A.M. Beex, and Fred C.G.J. Sweep
	JCO Feb 15 2004: 691–698. [Abstract] [Full Text] [PDF]
	Prognosis of Premenopausal Breast Cancer and Childbirth Prior to Diagnosis
	Kelly-Anne Phillips, Roger L. Milne, Michael L. Friedlander, Mark A. Jenkins, Margaret R.E. McCredie, Graham G. Giles, and John L. Hopper
	JCO Feb 15 2004: 699–705. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Change in Neurocognitive Functioning After Treatment With Cranial Radiation in Childhood
	Brenda J. Spiegler, Eric Bouffet, Mark L. Greenberg, James T. Rutka, and Donald J. Mabbott
	JCO Feb 15 2004: 706–713. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Measuring Quality of Life in Routine Oncology Practice Improves Communication and Patient Well-Being: A Randomized Controlled Trial
	Galina Velikova, Laura Booth, Adam B. Smith, Paul M. Brown, Pamela Lynch, Julia M. Brown, and Peter J. Selby
	JCO Feb 15 2004: 714–724. [Abstract] [Full Text] [PDF]
	Randomized, Double-Blind, Dose-Finding Study of Dexamethasone in Preventing Acute Emesis Induced by Anthracyclines, Carboplatin, or Cyclophosphamide:
	The Italian Group for Antiemetic Research
	JCO Feb 15 2004: 725–729. [Abstract] [Full Text] [PDF]

Epidemiology
	Enrollment of African Americans Onto Clinical Treatment Trials: Study Design Barriers
	Lucile L. Adams-Campbell, Chiledum Ahaghotu, Melvin Gaskins, Fitzroy W. Dawkins, Duane Smoot, Octavius D. Polk, Robert Gooding, and Robert L. DeWitty
	JCO Feb 15 2004: 730–734. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	Cancer Risks for Male Carriers of Germline Mutations in BRCA1 or BRCA2: A Review of the Literature
	Alexander Liede, Beth Y. Karlan, and Steven A. Narod
	JCO Feb 15 2004: 735–742. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Unusual Aspects of Melanoma: CASE 1. Jejunal Malignant Melanoma: Intestinal or Unknown Primary?

Liliana Montella, Antonella Vardanega, Angelo Farruggio, and Giorgio Bonciarelli

JCO Feb 15 2004: 743–744. [Full Text] [PDF]

Unusual Aspects of Melanoma: CASE 2. Regionally Advanced Nasal Cavity Melanoma

Michele Del Vecchio, Luca Gattinoni, Laura Lozza, and Emilio Bajetta

JCO Feb 15 2004: 745–746. [Full Text] [PDF]

Unusual Aspects of Melanoma: CASE 3. Melanoma-Associated Retinopathy Presenting With Night Blindness

Doreen A. Myers, Brian R. Bird, Susan M. Ryan, Peter Tormey, Paul McKenna, Seamus O’Reilly, and Oscar S. Breathnach

JCO Feb 15 2004: 746–748. [Full Text] [PDF]

SPECIAL DEPARTMENTS

Correspondence

Improved Outcome With Dose-Dense Chemotherapy

Bruce Keith, Rob Hall, and Aaron Scholnik

JCO Feb 15 2004: 749. [Full Text] [PDF]

Dose-Dense Chemotherapy As Adjuvant Treatment for Breast Cancer

Carl D. Atkins

JCO Feb 15 2004: 749-a–780. [Full Text] [PDF]

Dose Density by Any Other Name

William Hryniuk, Joseph Ragaz, and William Peters

JCO Feb 15 2004: 750–751. [Full Text] [PDF]

In Reply:

Marc L. Citron, Donald A. Berry, Constance Cirrincione, Clifford Hudis, Larry Norton, Eric P. Winer, William J. Gradishar, Nancy E. Davidson, Silvana Martino, Robert Livingston, James N. Ingle, John Carpenter, David Hurd, James F. Holland, Barbara Smith, Carolyn I. Sartor, Eleanor H. Leung, Jeffrey Abrams, Richard L Schilsky, and Hyman B. Muss

JCO Feb 15 2004: 751–753. [Full Text] [PDF]

Trial of Antidepressants for Mildly Depressed Cancer Patients Should Have Been Reported in a Manner Allowing Independent Evaluation of Investigators' Claims

Brigette A. Erwin, Patricia A. Sullivan, and Thomas R. Ten Have

JCO Feb 15 2004: 753–754. [Full Text] [PDF]

In Reply:

Michael J. Fisch, Jean L. Kristeller, Steven Passik, Patrick J. Loehrer, and Lawrence H. Einhorn

JCO Feb 15 2004: 754–756. [Full Text] [PDF]

TGFBR1*6A and Cancer: A Meta-Analysis of 12 Case-Control Studies

Boris Pasche, Virginia Kaklamani, Nanjiang Hou, Taya Young, Alfred Rademaker, Paolo Peterlongo, Nathan Ellis, Kenneth Offit, Trinidad Caldes, Michael Reiss, and Tongzhang Zheng

JCO Feb 15 2004: 756–758. [Full Text] [PDF]

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