EDITORIALS

Antithrombotic Therapy in Cancer

Nicholas R. Lemoine

JCO Apr 1 2005: 2119–2120. First published on Feb 7 2005; 10.1200/JCO.2005.10.975. [Full Text] [PDF]

The Frail Are Not Always Elderly

Matti S. Aapro

JCO Apr 1 2005: 2121–2122. First published on Feb 14 2005; 10.1200/JCO.2005.10.976. [Full Text] [PDF]

ORIGINAL REPORTS
Tumor Biology
	Randomized Comparison of Low Molecular Weight Heparin and Coumarin Derivatives on the Survival of Patients With Cancer and Venous Thromboembolism
	Agnes Y.Y. Lee, Frederick R. Rickles, Jim A. Julian, Michael Gent, Ross I. Baker, Chris Bowden, Ajay K. Kakkar, Martin Prins, and Mark N. Levine
	JCO Apr 1 2005: 2123–2129. First published on Feb 7 2005; 10.1200/JCO.2005.03.133. [Abstract] [Full Text] [PDF]
	The Effect of Low Molecular Weight Heparin on Survival in Patients With Advanced Malignancy
	Clara P.W. Klerk, Susanne M. Smorenburg, Hans-Martin Otten, Anthonie W.A. Lensing, Martin H. Prins, Franco Piovella, Paolo Prandoni, Monique M.E.M. Bos, Dick J. Richel, Geertjan van Tienhoven, and Harry R. Büller
	JCO Apr 1 2005: 2130–2135. First published on Feb 7 2005; 10.1200/JCO.2005.03.134. [Abstract] [Full Text] [PDF]

Lung Cancer
	Randomized Phase II Study of Two Gemcitabine Schedules for Patients With Impaired Performance Status (Karnofsky performance status 70) and Advanced Non–Small-Cell Lung Cancer
	S. Baka, L. Ashcroft, H. Anderson, M. Lind, P. Burt, R. Stout, I. Dowd, D. Smith, P. Lorigan, and N. Thatcher
	JCO Apr 1 2005: 2136–2144. First published on Feb 14 2005; 10.1200/JCO.2005.01.003. [Abstract] [Full Text] [PDF]
	Randomized Trial of Amifostine in Locally Advanced Non–Small-Cell Lung Cancer Patients Receiving Chemotherapy and Hyperfractionated Radiation: Radiation Therapy Oncology Group Trial 98-01
	Benjamin Movsas, Charles Scott, Corey Langer, Maria Werner-Wasik, Nicos Nicolaou, Ritsuko Komaki, Mitchell Machtay, Colum Smith, Rita Axelrod, Linda Sarna, Todd Wasserman, and Roger Byhardt
	JCO Apr 1 2005: 2145–2154. [Abstract] [Full Text] [PDF]

Breast Cancer
	Safety and Efficacy of Two Different Doses of Capecitabine in the Treatment of Advanced Breast Cancer in Older Women
	Emilio Bajetta, Giuseppe Procopio, Luigi Celio, Luca Gattinoni, Silvia Della Torre, Luigi Mariani, Laura Catena, Riccardo Ricotta, Raffaella Longarini, Nicoletta Zilembo, and Roberto Buzzoni
	JCO Apr 1 2005: 2155–2161. First published on Feb 14 2005; 10.1200/JCO.2005.02.167. [Abstract] [Full Text] [PDF]
	Phase II Study of Efficacy, Safety, and Pharmacokinetics of Trastuzumab Monotherapy Administered on a 3-Weekly Schedule
	José Baselga, Xavier Carbonell, Noel-Jaime Castañeda-Soto, Michael Clemens, Michael Green, Vernon Harvey, Serafin Morales, Claire Barton, and Parviz Ghahramani
	JCO Apr 1 2005: 2162–2171. [Abstract] [Full Text] [PDF]
	Postoperative Adjuvant Therapy With Tamoxifen, Tegafur Plus Uracil, or Both in Women With Node-Negative Breast Cancer: A Pooled Analysis of Six Randomized Controlled Trials
	Shinzaburo Noguchi, Hiroki Koyama, Junichi Uchino, Rikiya Abe, Shigeto Miura, Keizo Sugimachi, Kohei Akazawa, and Osahiko Abe
	JCO Apr 1 2005: 2172–2184. [Abstract] [Full Text] [PDF]
	Patients With an Unclassified Genetic Variant in the BRCA1 or BRCA2 Genes Show Different Clinical Features From Those With a Mutation
	Encarna B. Gómez-García, Ton Ambergen, Marinus J. Blok, and Arthur van den Wijngaard
	JCO Apr 1 2005: 2185–2190. [Abstract] [Full Text] [PDF]
	Prospective, Randomized Comparison of High-Dose Chemotherapy With Stem-Cell Support Versus Intermediate-Dose Chemotherapy After Surgery and Adjuvant Chemotherapy in Women With High-Risk Primary Breast Cancer: A Report of CALGB 9082, SWOG 9114, and NCIC MA-13
	William P. Peters, Gary L. Rosner, James J. Vredenburgh, Elizabeth J. Shpall, Michael Crump, Paul G. Richardson, Michael W. Schuster, Lawrence B. Marks, Constance Cirrincione, Larry Norton, I.C. Henderson, Richard L. Schilsky, and David D. Hurd
	JCO Apr 1 2005: 2191–2200. First published on Mar 14 2005; 10.1200/JCO.2005.10.202. [Abstract] [Full Text] [PDF]

Clinical Trials
	Improving Accrual of Older Persons to Cancer Treatment Trials: A Randomized Trial Comparing an Educational Intervention With Standard Information: CALGB 360001
	Gretchen G. Kimmick, Bercedis L. Peterson, Alice B. Kornblith, Jeanne Mandelblatt, Jeffrey L. Johnson, Judith Wheeler, Robin Heinze, Harvey J. Cohen, and Hyman B. Muss
	JCO Apr 1 2005: 2201–2207. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Increasing Incidence of Late Second Malignancies After Conditioning With Cyclophosphamide and Total-Body Irradiation and Autologous Bone Marrow Transplantation for Non-Hodgkin’s Lymphoma
	Jennifer R. Brown, Heather Yeckes, Jonathan W. Friedberg, Donna Neuberg, Helen Kim, Lee M. Nadler, and Arnold S. Freedman
	JCO Apr 1 2005: 2208–2214. First published on Mar 7 2005; 10.1200/JCO.2005.05.158. [Abstract] [Full Text] [PDF]
	Meta-Analysis to Evaluate the Role of Interferon in Follicular Lymphoma
	A.Z.S. Rohatiner, W.M. Gregory, B. Peterson, E. Borden, P. Solal-Celigny, A. Hagenbeek, R.I. Fisher, M. Unterhalt, R. Arranz, T. Chisesi, A. Aviles, and T.A. Lister
	JCO Apr 1 2005: 2215–2223. First published on Jan 31 2005; 10.1200/JCO.2005.06.146. [Abstract] [Full Text] [PDF]
	Vascular and Neoplastic Risk in a Large Cohort of Patients With Polycythemia Vera
	Roberto Marchioli, Guido Finazzi, Raffaele Landolfi, Jack Kutti, Heinz Gisslinger, Carlo Patrono, Raphael Marilus, Ana Villegas, Gianni Tognoni, and Tiziano Barbui
	JCO Apr 1 2005: 2224–2232. First published on Feb 14 2005; 10.1200/JCO.2005.07.062. [Abstract] [Full Text] [PDF]
	Primary CNS Lymphoma of T-Cell Origin: A Descriptive Analysis From the International Primary CNS Lymphoma Collaborative Group
	Tamara N. Shenkier, Jean-Yves Blay, Brian Patrick O’Neill, Philip Poortmans, Eckhard Thiel, Kristoph Jahnke, Lauren E. Abrey, Edward Neuwelt, Richard Tsang, Tracy Batchelor, Nancy Harris, Andrés J.M. Ferreri, Maurilio Ponzoni, Peter O’Brien, James Rubenstein, and Joseph M. Connors
	JCO Apr 1 2005: 2233–2239. [Abstract] [Full Text] [PDF]
	Concurrent Administration of High-Dose Rituximab Before and After Autologous Stem-Cell Transplantation for Relapsed Aggressive B-Cell Non-Hodgkin’s Lymphomas
	Issa F. Khouri, Rima M. Saliba, Chitra Hosing, Grace-Julia Okoroji, Sandra Acholonu, Paolo Anderlini, Daniel Couriel, Marcos De Lima, Michele L. Donato, Luis Fayad, Segio Giralt, Roy Jones, Martin Korbling, Farzaneh Maadani, John T. Manning, Barbara Pro, Elizabeth Shpall, Anas Younes, Peter McLaughlin, and Richard E. Champlin
	JCO Apr 1 2005: 2240–2247. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Prognostic Significance of Allelic Imbalance at the c-kit Gene Locus and c-kit Overexpression by Immunohistochemistry in Pediatric Osteosarcomas
	Natacha Entz-Werlé, Luc Marcellin, Marie-Pierre Gaub, Eric Guerin, Anne Schneider, Perrine Berard-Marec, Chantal Kalifa, Laurence Brugiere, Helène Pacquement, Claudine Schmitt, Marie-Dominique Tabone, Corinne Jeanne-Pasquier, Philippe Terrier, Frédérique Dijoud, Pierre Oudet, Patrick Lutz, and Annie Babin-Boilletot
	JCO Apr 1 2005: 2248–2255. [Abstract] [Full Text] [PDF]
	Serial Evaluation of Academic and Behavioral Outcome After Treatment With Cranial Radiation in Childhood
	Donald J. Mabbott, Brenda J. Spiegler, Mark L. Greenberg, James T. Rutka, Douglas J. Hyder, and Eric Bouffet
	JCO Apr 1 2005: 2256–2263. [Abstract] [Full Text] [PDF]
	Early Responses to Chemotherapy of Normal and Malignant Hematologic Cells Are Prognostic in Children With Acute Lymphoblastic Leukemia
	Stephen J. Laughton, Lesley J. Ashton, Edward Kwan, Murray D. Norris, Michelle Haber, and Glenn M. Marshall
	JCO Apr 1 2005: 2264–2271. [Abstract] [Full Text] [PDF]
	Risk of New Cancers After Radiotherapy in Long-Term Survivors of Retinoblastoma: An Extended Follow-Up
	Ruth A. Kleinerman, Margaret A. Tucker, Robert E. Tarone, David H. Abramson, Johanna M. Seddon, Marilyn Stovall, Frederick P. Li, and Joseph F. Fraumeni, Jr
	JCO Apr 1 2005: 2272–2279. [Abstract] [Full Text] [PDF]
	Unequivocal Delineation of Clinicogenetic Subgroups and Development of a New Model for Improved Outcome Prediction in Neuroblastoma
	Jo Vandesompele, Michael Baudis, Katleen De Preter, Nadine Van Roy, Peter Ambros, Nick Bown, Christian Brinkschmidt, Holger Christiansen, Valérie Combaret, Maria Lastowska, James Nicholson, Anne O'Meara, Dominique Plantaz, Raymond Stallings, Bénédicte Brichard, Caroline Van den Broecke, Sylvia De Bie, Anne De Paepe, Geneviève Laureys, and Frank Speleman
	JCO Apr 1 2005: 2280–2299. [Abstract] [Full Text] [PDF]

Surgical Oncology
	Merkel Cell Carcinoma: Prognosis and Treatment of Patients From a Single Institution
	Peter J. Allen, Wilbur B. Bowne, David P. Jaques, Murray F. Brennan, Klaus Busam, and Daniel G. Coit
	JCO Apr 1 2005: 2300–2309. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Chemoradiation With and Without Surgery in Patients With Locally Advanced Squamous Cell Carcinoma of the Esophagus
	Michael Stahl, Martin Stuschke, Nils Lehmann, Hans-Joachim Meyer, Martin K. Walz, Siegfried Seeber, Bodo Klump, Wilfried Budach, Reinhard Teichmann, Marcus Schmitt, Gerd Schmitt, Claus Franke, and Hansjochen Wilke
	JCO Apr 1 2005: 2310–2317. [Abstract] [Full Text] [PDF] [Publisher's Note]
	Low Microsatellite Instability Is Associated With Poor Prognosis in Stage C Colon Cancer
	Maija R.J. Kohonen-Corish, Joseph J. Daniel, Charles Chan, Betty P.C. Lin, Sun Young Kwun, Owen F. Dent, Varinderpal S. Dhillon, Ronald J.A. Trent, Pierre H. Chapuis, and E. Leslie Bokey
	JCO Apr 1 2005: 2318–2324. [Abstract] [Full Text] [PDF]
	Outcome Results of the 1996-1999 Patterns of Care Survey of the National Practice for Patients Receiving Radiation Therapy for Carcinoma of the Esophagus
	Mohan Suntharalingam, Jennifer Moughan, Lawrence R. Coia, Mark J. Krasna, Lisa Kachnic, Daniel G. Haller, Christopher G. Willet, Madhu J. John, Bruce D. Minsky, and Jean B. Owen
	JCO Apr 1 2005: 2325–2331. [Abstract] [Full Text] [PDF]
	Combining Gemcitabine and Capecitabine in Patients With Advanced Biliary Cancer: A Phase II Trial
	Jennifer J. Knox, David Hedley, Amit Oza, Ron Feld, Lillian L. Siu, Eric Chen, Mahsan Nematollahi, Gregory R. Pond, Jessica Zhang, and Malcolm J. Moore
	JCO Apr 1 2005: 2332–2338. [Abstract] [Full Text] [PDF]
	Prognostic Role of Interleukin-1ß Gene and Interleukin-1 Receptor Antagonist Gene Polymorphisms in Patients With Advanced Gastric Cancer
	Francesco Graziano, Annamaria Ruzzo, Daniele Santini, Bostjan Humar, Giuseppe Tonini, Vincenzo Catalano, Rossana Berardi, Francesca Pizzagalli, Federica Arduini, Italo Bearzi, Mario Scartozzi, Stefano Cascinu, Enrica Testa, Rita Ficarelli, and Mauro Magnani
	JCO Apr 1 2005: 2339–2345. [Abstract] [Full Text] [PDF]

Melanoma
	Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma
	Mark E. Dudley, John R. Wunderlich, James C. Yang, Richard M. Sherry, Suzanne L. Topalian, Nicholas P. Restifo, Richard E. Royal, Udai Kammula, Don E. White, Sharon A. Mavroukakis, Linda J. Rogers, Gerald J. Gracia, Stephanie A. Jones, David P. Mangiameli, Michelle M. Pelletier, Juan Gea-Banacloche, Michael R. Robinson, David M. Berman, Armando C. Filie, Andrea Abati, and Steven A. Rosenberg
	JCO Apr 1 2005: 2346–2357. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Extracapsular Extension of Pelvic Lymph Node Metastases From Urothelial Carcinoma of the Bladder Is an Independent Prognostic Factor
	Achim Fleischmann, George N. Thalmann, Regula Markwalder, and Urs E. Studer
	JCO Apr 1 2005: 2358–2365. [Abstract] [Full Text] [PDF]

Palliative Care
	Effects of Parenteral Hydration in Terminally Ill Cancer Patients: A Preliminary Study
	Eduardo Bruera, Raul Sala, Maria Antonieta Rico, Jairo Moyano, Carlos Centeno, Jie Willey, and J. Lynn Palmer
	JCO Apr 1 2005: 2366–2371. [Abstract] [Full Text] [PDF]

Radiation Oncology
	Randomized Phase II Study of Temozolomide and Radiotherapy Compared With Radiotherapy Alone in Newly Diagnosed Glioblastoma Multiforme
	Helen Athanassiou, Maria Synodinou, Evagelos Maragoudakis, Mihalis Paraskevaidis, Cosmas Verigos, Despina Misailidou, Dosia Antonadou, George Saris, Konstantinos Beroukas, and Pantelis Karageorgis
	JCO Apr 1 2005: 2372–2377. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Effectiveness of Physical Activity on Cardiorespiratory Fitness and Health-Related Quality of Life in Young and Middle-Aged Cancer Patients Shortly After Chemotherapy
	Lene Thorsen, Eva Skovlund, Sigmund B. Strømme, Kjersti Hornslien, Alv A. Dahl, and Sophie D. Fosså
	JCO Apr 1 2005: 2378–2388. [Abstract] [Full Text] [PDF]
	Study of Anxiety Disorder and Depression in Long-Term Survivors of Testicular Cancer
	Alv A. Dahl, Carl Fredrik Haaland, Arnstein Mykletun, Roy Bremnes, Olav Dahl, Olbjørn Klepp, Erik Wist, and Sophie D. Fosså
	JCO Apr 1 2005: 2389–2395. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Arsenic Trioxide: New Clinical Experience With an Old Medication in Hematologic Malignancies
	Dan Douer and Martin S. Tallman
	JCO Apr 1 2005: 2396–2410. [Abstract] [Full Text] [PDF]
	Possible Future Issues in the Treatment of Glioblastomas: Special Emphasis on Cell Migration and the Resistance of Migrating Glioblastoma Cells to Apoptosis
	Florence Lefranc, Jacques Brotchi, and Robert Kiss
	JCO Apr 1 2005: 2411–2422. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Side Effects and Good Effects from New Chemotherapeutic Agents: CASE 1. Gefitinib-Induced Interstitial Fibrosis

Neil C. Nagaria, Janet Cogswell, Jin K. Choe, and Basil Kasimis

JCO Apr 1 2005: 2423–2424. [Full Text] [PDF]

Side Effects and Good Effects from New Chemotherapeutic Agents: CASE 2. Thalidomide-Induced Interstitial Pneumonitis

Masahiro Onozawa, Satoshi Hashino, Susumu Sogabe, Masahira Haneda, Hiromasa Horimoto, Koh Izumiyama, Takeshi Kondo, Luis Perez Aldana, Kunio Hamada, and Masahiro Asaka

JCO Apr 1 2005: 2425–2426. [Full Text] [PDF]

Side Effects and Good Effects from New Chemotherapeutic Agents: CASE 3. Bortezomib in Primary Refractory Plasmacytoma

C.S. Chim, G.C. Ooi, F. Loong, A.W.M. Au, and A.K.W. Lie

JCO Apr 1 2005: 2426–2428. [Full Text] [PDF]

ART OF ONCOLOGY

Witness

Daniel Rayson

JCO Apr 1 2005: 2429–2430. [Full Text] [PDF]

SPECIAL DEPARTMENTS

Correspondence

Adjuvant Interferon Therapy for Melanoma

Barry Hancock, Keith Wheatley, Natalie Ives, and Martin Gore

JCO Apr 1 2005: 2431. [Full Text] [PDF]

In Reply:

Stergios J. Moschos, Stephanie Land, John M. Kirkwood, and Lynn M. Schuchter

JCO Apr 1 2005: 2431-a–2432. [Full Text] [PDF]

Highly Active Antiretroviral Therapy in AIDS-Associated Kaposi's Sarcoma (KS): Implications for the Design of Therapeutic Trials in Patients With Advanced Symptomatic KS

Guglielmo Nasti and Umberto Tirelli

JCO Apr 1 2005: 2433. [Full Text] [PDF]

In Reply:

Susan E. Krown

JCO Apr 1 2005: 2433-a–2434. [Full Text] [PDF]

Elevated Body Mass Index Predicts for Longer Overall Survival Duration in Men With Metastatic Hormone-Refractory Prostate Cancer

Susan Halabi, Eric J. Small, and Nicholas J. Vogelzang

JCO Apr 1 2005: 2434–2435. [Full Text] [PDF]

In Reply:

Stephen Freedland

JCO Apr 1 2005: 2435. [Full Text] [PDF]

CA125 Nadir Values As a Prognostic Factor in Epithelial Ovarian Cancer

Kadri Altundag, Ozden Altundag, Paolo Morandi, and Mehmet Gunduz

JCO Apr 1 2005: 2435-a–2436. [Full Text] [PDF]

In Reply:

Sandro Pignata, Francesco Perrone, Massimo Di Maio, Ciro Gallo, and Sabino De Placido

JCO Apr 1 2005: 2436–2437. [Full Text] [PDF]

Rationing and Decision Making

Raymond P. Abratt

JCO Apr 1 2005: 2437–2438. [Full Text] [PDF]

In Reply:

Reshma Jagsi, Thomas F. DeLaney, Karen Donelan, and Nancy J. Tarbell

JCO Apr 1 2005: 2438. [Full Text] [PDF]

Overestimation of Lung Cancer Mortality in a Computed Tomography–Screened Population

Frederic W. Grannis

JCO Apr 1 2005: 2439–2440. [Full Text] [PDF]

In Reply:

Edward F. Patz, Jr, Stephen J. Swensen, and James E. Herndon, II

JCO Apr 1 2005: 2440–2441. [Full Text] [PDF]

Pattern of Care at the End of Life: Does Age Make a Difference?

Christine Simmons and Mark Clemons

JCO Apr 1 2005: 2441. [Full Text] [PDF]

In Reply:

Bruno Gagnon and Nancy Mayo

JCO Apr 1 2005: 2441-a–2442. [Full Text] [PDF]

Looking for the Role of NSAIDs in Cancer Pain

Sebastiano Mercadante

JCO Apr 1 2005: 2442–2443. [Full Text] [PDF]

In Reply:

Ewan McNicol and Daniel B. Carr

JCO Apr 1 2005: 2443. [Full Text] [PDF]

Errata

Erratum

JCO Apr 1 2005: 2444. [Full Text] [PDF]

Erratum

JCO Apr 1 2005: 2444-a. [Full Text] [PDF]

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