EDITORIALS

Medical and Pediatric Oncology, Not Adult and Pediatric Oncology

Laurence H. Baker

JCO Jun 20 2005: 4003–4005. First published on Mar 14 2005; 10.1200/JCO.2005.11.952. [Full Text] [PDF]

Catheter-Associated Thrombosis: Thromboprophylaxis or Not?

M. Levine and A.K. Kakkar

JCO Jun 20 2005: 4006–4008. First published on Mar 14 2005; 10.1200/JCO.2005.12.901. [Full Text] [PDF]

Changing the Way We Think About Chronic Lymphocytic Leukemia

Thomas S. Lin, Michael R. Grever, and John C. Byrd

JCO Jun 20 2005: 4009–4012. First published on Mar 14 2005; 10.1200/JCO.2005.08.964. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

Cancer Patients' and Patient Advocates' Perspectives on a Novel Information Source: A Qualitative Study of The Art of Oncology, When the Tumor Is Not the Target

Kristin S. Vickers, Julie C. Hathaway, Christi A. Patten, Matthew M. Clark, Teresa L. Britt, Sherry A. Looker, Phaedra T. Johnson, and Charles L. Loprinzi

JCO Jun 20 2005: 4013–4020. [Full Text] [PDF]

ORIGINAL REPORTS
Pediatric Oncology
	Adult-Type Soft Tissue Sarcomas in Pediatric-Age Patients: Experience at the Istituto Nazionale Tumori in Milan
	Andrea Ferrari, Michela Casanova, Paola Collini, Cristina Meazza, Roberto Luksch, Maura Massimino, Graziella Cefalo, Monica Terenziani, Filippo Spreafico, Serena Catania, Lorenza Gandola, Alessandro Gronchi, Luigi Mariani, and Franca Fossati-Bellani
	JCO Jun 20 2005: 4021–4030. First published on Mar 14 2005; 10.1200/JCO.2005.02.053. [Abstract] [Full Text] [PDF]
	Phase II Trial of Neoadjuvant Vincristine, Ifosfamide, and Doxorubicin With Granulocyte Colony-Stimulating Factor Support in Children and Adolescents With Advanced-Stage Nonrhabdomyosarcomatous Soft Tissue Sarcomas: A Pediatric Oncology Group Study
	Alberto S. Pappo, Meenakshi Devidas, Jessee Jenkins, Bhaskar Rao, Robert Marcus, Patrick Thomas, Mark Gebhardt, Charles Pratt, and Holcombe E. Grier
	JCO Jun 20 2005: 4031–4038. First published on Mar 14 2005; 10.1200/JCO.2005.03.209. [Abstract] [Full Text] [PDF]
	Improved Response in High-Risk Neuroblastoma With Protracted Topotecan Administration Using a Pharmacokinetically Guided Dosing Approach
	Victor M. Santana, Wayne L. Furman, Catherine A. Billups, Fredric Hoffer, Andrew M. Davidoff, Peter J. Houghton, and Clinton F. Stewart
	JCO Jun 20 2005: 4039–4047. [Abstract] [Full Text] [PDF]
	Impact of Latent Epstein-Barr Virus Infection on Outcome in Children and Adolescents With Hodgkin's Lymphoma
	Alexander Claviez, Markus Tiemann, Heike Lüders, Matthias Krams, Reza Parwaresch, Günther Schellong, and Wolfgang Dörffel
	JCO Jun 20 2005: 4048–4056. [Abstract] [Full Text] [PDF]

Cancer-Related Complications
	Enoxaparin for the Prevention of Venous Thromboembolism Associated With Central Vein Catheter: A Double-Blind, Placebo-Controlled, Randomized Study in Cancer Patients
	Melina Verso, Giancarlo Agnelli, Sergio Bertoglio, Franco C. Di Somma, Francesco Paoletti, Walter Ageno, Mario Bazzan, Pasquale Parise, Roberto Quintavalla, Emanuele Naglieri, Armando Santoro, Davide Imberti, Mariella Sorarù, and Stefano Mosca
	JCO Jun 20 2005: 4057–4062. First published on Mar 14 2005; 10.1200/JCO.2005.06.084. [Abstract] [Full Text] [PDF]
	Randomized Placebo-Controlled Study of Low-Dose Warfarin for the Prevention of Central Venous Catheter–Associated Thrombosis in Patients With Cancer
	Stephen Couban, Michael Goodyear, Margot Burnell, Sean Dolan, Parveen Wasi, David Barnes, Darlene MacLeod, Erica Burton, Pantelis Andreou, and David R. Anderson
	JCO Jun 20 2005: 4063–4069. First published on Mar 14 2005; 10.1200/JCO.2005.10.192. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Chemoimmunotherapy With Fludarabine, Cyclophosphamide, and Rituximab for Relapsed and Refractory Chronic Lymphocytic Leukemia
	William Wierda, Susan O’Brien, Sijin Wen, Stefan Faderl, Guillermo Garcia-Manero, Deborah Thomas, Kim-Anh Do, Jorge Cortes, Charles Koller, Miloslav Beran, Alessandra Ferrajoli, Francis Giles, Susan Lerner, Maher Albitar, Hagop Kantarjian, and Michael Keating
	JCO Jun 20 2005: 4070–4078. First published on Mar 14 2005; 10.1200/JCO.2005.12.516. [Abstract] [Full Text] [PDF]
	Early Results of a Chemoimmunotherapy Regimen of Fludarabine, Cyclophosphamide, and Rituximab As Initial Therapy for Chronic Lymphocytic Leukemia
	Michael J. Keating, Susan O’Brien, Maher Albitar, Susan Lerner, William Plunkett, Francis Giles, Michael Andreeff, Jorge Cortes, Stefan Faderl, Deborah Thomas, Charles Koller, William Wierda, Michelle A. Detry, Alice Lynn, and Hagop Kantarjian
	JCO Jun 20 2005: 4079–4088. First published on Mar 14 2005; 10.1200/JCO.2005.12.051. [Abstract] [Full Text] [PDF]
	Phase II Study of G3139, a Bcl-2 Antisense Oligonucleotide, in Combination With Dexamethasone and Thalidomide in Relapsed Multiple Myeloma Patients
	Ashraf Z. Badros, Olga Goloubeva, Aaron P. Rapoport, Bashi Ratterree, Natalie Gahres, Barry Meisenberg, Naoko Takebe, Meyer Heyman, James Zwiebel, Howard Streicher, Christopher D. Gocke, Dragana Tomic, Jodi A. Flaws, Bin Zhang, and Robert G. Fenton
	JCO Jun 20 2005: 4089–4099. First published on May 2 2005; 10.1200/JCO.2005.14.381. [Abstract] [Full Text] [PDF]
	ABL Mutations in Late Chronic Phase Chronic Myeloid Leukemia Patients With Up-Front Cytogenetic Resistance to Imatinib Are Associated With a Greater Likelihood of Progression to Blast Crisis and Shorter Survival: A Study by the GIMEMA Working Party on Chronic Myeloid Leukemia
	Simona Soverini, Giovanni Martinelli, Gianantonio Rosti, Simona Bassi, Marilina Amabile, Angela Poerio, Barbara Giannini, Elena Trabacchi, Fausto Castagnetti, Nicoletta Testoni, Simona Luatti, Antonio de Vivo, Daniela Cilloni, Barbara Izzo, Milena Fava, Elisabetta Abruzzese, Daniele Alberti, Fabrizio Pane, Giuseppe Saglio, and Michele Baccarani
	JCO Jun 20 2005: 4100–4109. First published on May 2 2005; 10.1200/JCO.2005.05.531. [Abstract] [Full Text] [PDF]
	Phase III Randomized Multicenter Study of a Humanized Anti-CD33 Monoclonal Antibody, Lintuzumab, in Combination With Chemotherapy, Versus Chemotherapy Alone in Patients With Refractory or First-Relapsed Acute Myeloid Leukemia
	Eric J. Feldman, Joseph Brandwein, Richard Stone, Matt Kalaycio, Joseph Moore, Julie O'Connor, Nancy Wedel, Gail J. Roboz, Carole Miller, Raj Chopra, Joseph C. Jurcic, Randy Brown, W. Christopher Ehmann, Philip Schulman, Stanley R. Frankel, Daniel De Angelo, and David Scheinberg
	JCO Jun 20 2005: 4110–4116. [Abstract] [Full Text] [PDF]
	Long-Term Results of the R-CHOP Study in the Treatment of Elderly Patients With Diffuse Large B-Cell Lymphoma: A Study by the Groupe d'Etude des Lymphomes de l'Adulte
	P. Feugier, A. Van Hoof, C. Sebban, P. Solal-Celigny, R. Bouabdallah, C. Fermé, B. Christian, E. Lepage, H. Tilly, F. Morschhauser, P. Gaulard, G. Salles, A. Bosly, C. Gisselbrecht, F. Reyes, and B. Coiffier
	JCO Jun 20 2005: 4117–4126. First published on May 2 2005; 10.1200/JCO.2005.09.131. [Abstract] [Full Text] [PDF]

Radiation Oncology
	Use of Magnetic Resonance Imaging to Assess Blood-Brain/Blood-Glioma Barrier Opening During Conformal Radiotherapy
	Yue Cao, Christina I. Tsien, Zhou Shen, Daniel S. Tatro, Randall Ten Haken, Marc L. Kessler, Thomas L. Chenevert, and Theodore S. Lawrence
	JCO Jun 20 2005: 4127–4136. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	Randomized Trial of Neoadjuvant Chemotherapy Comparing Paclitaxel, Ifosfamide, and Cisplatin With Ifosfamide and Cisplatin Followed by Radical Surgery in Patients With Locally Advanced Squamous Cell Cervical Carcinoma: The SNAP01 (Studio Neo-Adjuvante Portio) Italian Collaborative Study
	Alessandro Buda, Roldano Fossati, Nicoletta Colombo, Francesca Fei, Irene Floriani, Desiderio Gueli Alletti, Dionyssios Katsaros, Fabio Landoni, Andrea Lissoni, Carmine Malzoni, Enrico Sartori, Paolo Scollo, Valter Torri, Paolo Zola, and Costantino Mangioni
	JCO Jun 20 2005: 4137–4145. [Abstract] [Full Text] [PDF]

Surgical Oncology
	Achieving Optimal Outcomes After Radical Prostatectomy
	Jeffery W. Saranchuk, Michael W. Kattan, Elena Elkin, A. Karim Touijer, Peter T. Scardino, and James A. Eastham
	JCO Jun 20 2005: 4146–4151. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Phase I Pharmacokinetic and Pharmacodynamic Study of 17-Allylamino, 17-Demethoxygeldanamycin in Patients With Advanced Malignancies
	Udai Banerji, Anne O'Donnell, Michelle Scurr, Simon Pacey, Sarah Stapleton, Yasmin Asad, Laura Simmons, Alison Maloney, Florence Raynaud, Maeli Campbell, Michael Walton, Sunil Lakhani, Stanley Kaye, Paul Workman, and Ian Judson
	JCO Jun 20 2005: 4152–4161. [Abstract] [Full Text] [PDF]
	Phase I Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PTK787/ZK 222584 Administered Twice Daily in Patients With Advanced Cancer
	Anne L. Thomas, Bruno Morgan, Mark A. Horsfield, Anthony Higginson, Andrea Kay, Lucy Lee, Eric Masson, Marie Puccio-Pick, Dirk Laurent, and William P. Steward
	JCO Jun 20 2005: 4162–4171. First published on May 2 2005; 10.1200/JCO.2005.09.034. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Randomized Phase II/III Trial of Interferon Alfa-2a With and Without 13-cis-Retinoic Acid in Patients With Progressive Metastatic Renal Cell Carcinoma: The European Organisation for Research and Treatment of Cancer Genito-Urinary Tract Cancer Group (EORTC 30951)
	Nina Aass, Pieter H.M. De Mulder, Gerald H.J. Mickisch, Peter Mulders, Allan T. van Oosterom, Hein van Poppel, Sophie D. Fossa, Linda de Prijck, and Richard J. Sylvester
	JCO Jun 20 2005: 4172–4178. [Abstract] [Full Text] [PDF]

Breast Cancer
	Risk of Acute Myeloid Leukemia and Myelodysplastic Syndrome in Trials of Adjuvant Epirubicin for Early Breast Cancer: Correlation With Doses of Epirubicin and Cyclophosphamide
	Claudio Praga, Jonas Bergh, Judith Bliss, Jacques Bonneterre, Bruno Cesana, R. Charles Coombes, Pierre Fargeot, Annika Folin, Pierre Fumoleau, Rosa Giuliani, Pierre Kerbrat, Michel Hery, Jonas Nilsson, Francesco Onida, Martine Piccart, Lois Shepherd, Patrick Therasse, Jacques Wils, and David Rogers
	JCO Jun 20 2005: 4179–4191. [Abstract] [Full Text] [PDF]
	Chemotherapy for Breast Cancer During Pregnancy: An 18-Year Experience From Five London Teaching Hospitals
	Alistair E. Ring, Ian E. Smith, Alison Jones, Catherine Shannon, Eleni Galani, and Paul A. Ellis
	JCO Jun 20 2005: 4192–4197. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	Colony-Stimulating Factors for Chemotherapy-Induced Febrile Neutropenia: A Meta-Analysis of Randomized Controlled Trials
	Otavio A.C. Clark, Gary H. Lyman, Aldemar A. Castro, Luciana G.O. Clark, and Benjamin Djulbegovic
	JCO Jun 20 2005: 4198–4214. [Abstract] [Full Text] [PDF]

BIOLOGY OF NEOPLASIA
	Cyclin D1 in Breast Cancer Pathogenesis
	Andrew Arnold and Alexandros Papanikolaou
	JCO Jun 20 2005: 4215–4224. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

CNS Manifestations of Malignancies: CASE 1. Conjunctival Relapse of Acute Lymphoblastic Leukemia Heralding Pituitary and CNS Disease

Charmaine Hon, Ricky W. Law, Tony W. Shek, and Wing Y. Au

JCO Jun 20 2005: 4225–4226. [Full Text] [PDF]

CNS Manifestations of Malignancies: CASE 2. Skull and Brain Metastasis From Tibial Osteosarcoma

Robert J. Weil, Russell R. Lonser, and Martha M. Quezado

JCO Jun 20 2005: 4226–4229. [Full Text] [PDF]

CNS Manifestations of Malignancies: CASE 3. Leukemic Optic Neuropathy Complicating Leukemia Cutis

Charmaine Hon, Edmond S.K. Ma, Kin Yau, and Wing Y. Au

JCO Jun 20 2005: 4229–4230. [Full Text] [PDF]

ART OF ONCOLOGY

Unrealistic Expectations

Lynn C. Hartmann

JCO Jun 20 2005: 4231–4232. [Full Text] [PDF]

Commentary on "Unrealistic Expectations"

Gregory P. Kalemkerian

JCO Jun 20 2005: 4233–4234. [Full Text] [PDF]

SPECIAL DEPARTMENTS

Correspondence

How Lymphotoxic Is Dose-Intensified Temozolomide? The Glioblastoma Experience

Wolfgang Wick and Michael Weller

JCO Jun 20 2005: 4235–4236. [Full Text] [PDF]

In Reply:

Y.B. Su, Susan E. Krown, Philip O. Livingston, Jedd D. Wolchok, and Paul B. Chapman

JCO Jun 20 2005: 4236. [Full Text] [PDF]

Fellows’ Forum Forgotten?

Archie Bleyer

JCO Jun 20 2005: 4237. [Full Text] [PDF]

Weekly Epirubicin Plus Tamoxifen Versus Tamoxifen Alone As Adjuvant Treatment of Operable, Node-Positive, Elderly Breast Cancer Patients

Carol Alliot

JCO Jun 20 2005: 4237-a–4238. [Full Text] [PDF]

In Reply:

Pierre Fargeot

JCO Jun 20 2005: 4238–4239. [Full Text] [PDF]

Radiation Therapy and Tamoxifen: Concurrent or Sequential? It's No Longer the Question!

David Azria, Andre Pelegrin, Jean-Bernard Dubois, Rene-Olivier Mirimanoff, and Mahmut Ozsahin

JCO Jun 20 2005: 4239–4241. [Full Text] [PDF]

In Reply:

Bruce G. Haffty, Lori Pierce, Eleanor Harris, and Larry Solin

JCO Jun 20 2005: 4241–4242. [Full Text] [PDF]

Potential Risk of a Common Hereditary Thrombophilia and Adjuvant Chemotherapy for Low-Stage Breast Cancer

Susan F. Ely

JCO Jun 20 2005: 4242–4243. [Full Text] [PDF]

Cognitive Impairment, Aromatase Inhibitors, and Age

Paolo Tralongo, Anna Di Mari, and Francesco Ferrau'

JCO Jun 20 2005: 4243. [Full Text] [PDF]

Clinical Responses to Gefinitib After Failure of Treatment With Cetuximab in Advanced Non–Small-Cell Lung Cancer

Luis E. Raez, Gilberto Lopes, and Rogerio Lilenbaum

JCO Jun 20 2005: 4244–4245. [Full Text] [PDF]

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