OVERVIEW

Integrating Molecular Oncology Into Clinical Practice: Antiangiogenic Therapy

Lee M. Ellis and S. Gail Eckhardt

JCO Feb 10 2005: 937–938. [Full Text] [PDF]

ORIGINAL REPORTS
Translational Studies
	A Multitargeted, Metronomic, and Maximum-Tolerated Dose "Chemo-Switch" Regimen is Antiangiogenic, Producing Objective Responses and Survival Benefit in a Mouse Model of Cancer
	Kristian Pietras and Douglas Hanahan
	JCO Feb 10 2005: 939–952. First published on Nov 22 2004; 10.1200/JCO.2005.07.093. [Abstract] [Full Text] [PDF]
	Tumor-Associated Macrophages: The Double-Edged Sword in Cancer Progression
	Jeremy J.W. Chen, Yi-Chen Lin, Pei-Li Yao, Ang Yuan, Hsang-Yu Chen, Chia-Tung Shun, Meng-Feng Tsai, Chun-Houh Chen, and Pan-Chyr Yang
	JCO Feb 10 2005: 953–964. First published on Dec 14 2004; 10.1200/JCO.2005.12.172. [Abstract] [Full Text] [PDF]

Clinical Trials
	Phase I Clinical and Pharmacokinetic Study of the Novel Raf Kinase and Vascular Endothelial Growth Factor Receptor Inhibitor BAY 43-9006 in Patients With Advanced Refractory Solid Tumors
	Dirk Strumberg, Heike Richly, Ralf A. Hilger, Norbert Schleucher, Sonke Korfee, Mitra Tewes, Markus Faghih, Erich Brendel, Dimitris Voliotis, Claus G. Haase, Brian Schwartz, Ahmad Awada, Rudolf Voigtmann, Max E. Scheulen, and Siegfried Seeber
	JCO Feb 10 2005: 965–972. First published on Dec 21 2004; 10.1200/JCO.2005.06.124. [Abstract] [Full Text] [PDF]
	Blockade of Platelet-Derived Growth Factor Receptor-Beta by CDP860, a Humanized, PEGylated di-Fab', Leads to Fluid Accumulation and Is Associated With Increased Tumor Vascularized Volume
	G.C. Jayson, G.J.M. Parker, S. Mullamitha, J.W. Valle, M. Saunders, L. Broughton, J. Lawrance, B. Carrington, C. Roberts, B. Issa, D.L. Buckley, S. Cheung, K. Davies, Y. Watson, K. Zinkewich-Péotti, L. Rolfe, and A. Jackson
	JCO Feb 10 2005: 973–981. First published on Oct 4 2004; 10.1200/JCO.2005.01.032. [Abstract] [Full Text] [PDF]
	Imatinib-Induced Regression of AIDS-Related Kaposi's Sarcoma
	Henry B. Koon, Glenn J. Bubley, Liron Pantanowitz, David Masiello, Brad Smith, Katherine Crosby, JoAnn Proper, Will Weeden, Thomas E. Miller, Pamela Chatis, Merrill J. Egorin, Steven R. Tahan, and Bruce J. Dezube
	JCO Feb 10 2005: 982–989. First published on Nov 30 2004; 10.1200/JCO.2005.06.079. [Abstract] [Full Text] [PDF]
	Angiogenesis Inhibitor IM862 Is Ineffective Against AIDS-Kaposi's Sarcoma in a Phase III Trial, but Demonstrates Sustained, Potent Effect of Highly Active Antiretroviral Therapy: From the AIDS Malignancy Consortium and IM862 Study Team
	Ariela Noy, David T. Scadden, Jeannette Lee, Bruce J. Dezube, David Aboulafia, Anil Tulpule, Sharon Walmsley, and Parkash Gill
	JCO Feb 10 2005: 990–998. First published on Dec 14 2004; 10.1200/JCO.2005.11.043. [Abstract] [Full Text] [PDF]

General Molecular Oncology Clinical Trial
	Intratumoral Injection of Dendritic Cells Engineered to Secrete Interleukin-12 by Recombinant Adenovirus in Patients With Metastatic Gastrointestinal Carcinomas
	Guillermo Mazzolini, Carlos Alfaro, Bruno Sangro, Esperanza Feijoó, Juan Ruiz, Alberto Benito, Iñigo Tirapu, Ainhoa Arina, Josu Sola, Maite Herraiz, Felipe Lucena, Cristina Olagüe, José Subtil, Jorge Quiroga, Ignacio Herrero, Belén Sádaba, Maurizio Bendandi, Cheng Qian, Jesús Prieto, and Ignacio Melero
	JCO Feb 10 2005: 999–1010. First published on Dec 14 2004; 10.1200/JCO.2005.00.463. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
	Daniel J. Hicklin and Lee M. Ellis
	JCO Feb 10 2005: 1011–1027. First published on Dec 7 2004; 10.1200/JCO.2005.06.081. [Abstract] [Full Text] [PDF]
	Biology and Clinical Development of Vascular Endothelial Growth Factor–Targeted Therapy in Renal Cell Carcinoma
	Brian I. Rini and Eric J. Small
	JCO Feb 10 2005: 1028–1043. First published on Nov 8 2004; 10.1200/JCO.2005.01.186. [Abstract] [Full Text] [PDF]

GLOSSARY

Glossary

JCO Feb 10 2005: 1047–1052. [PDF]

SPECIAL DEPARTMENTS

Correspondence

Interleukin-6 and C-Reactive Protein in Metastatic Renal Cell Carcinoma

Ozden Altundag, Kadri Altundag, and Esra Gunduz

JCO Feb 10 2005: 1044. [Full Text] [PDF]

In Reply:

Sylvie Negrier, David Perol, Christine Menetrier-Caux, Jean-Yves Blay, and Bernard Escudier

JCO Feb 10 2005: 1044a–1045. [Full Text] [PDF]

First, Do No Harm; Second, Make Sure You Are Doing Some Good

Mark Goodman

JCO Feb 10 2005: 1045–1046. [Full Text] [PDF]

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