EDITORIALS

Anaplastic Oligodendroglial Tumors: A Tale of Two Trials

Mark R. Gilbert and Frederick F. Lang

JCO Jun 20 2006: 2689–2690. [Full Text] [PDF]

Cyclooxygenase-2 Selective Inhibitors and Prostate Cancer: What Is the Clinical Benefit?

Raymond N. DuBois

JCO Jun 20 2006: 2691–2693. [Full Text] [PDF]

Surgery of the Primary Tumor in Metastatic Breast Cancer: Closing the Barn Door After the Horse Has Bolted?

Monica Morrow and Lori Goldstein

JCO Jun 20 2006: 2694–2696. First published on May 15 2006; 10.1200/JCO.2006.05.9824. [Full Text] [PDF]

Adjuvant Chemotherapy Use and Outcomes in Older Women With Breast Cancer: What Have We Learned?

Rebecca A. Silliman and Patricia A. Ganz

JCO Jun 20 2006: 2697–2699. [Full Text] [PDF]

Oral Second-Line Chemotherapy for Advanced Non–Small-Cell Lung Cancer: The Bottom Line

David R. Gandara and Angela M. Davies

JCO Jun 20 2006: 2700–2701. First published on May 8 2006; 10.1200/JCO.2006.06.1432. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

Downstaging or Downsizing: Time for a New Staging System in Advanced Colorectal Cancer?

Graeme Poston, Rene Adam, and Jean-Nicolas Vauthey

JCO Jun 20 2006: 2702–2706. [Full Text] [PDF]

ORIGINAL REPORTS
Neurooncology
	Phase III Trial of Chemotherapy Plus Radiotherapy Compared With Radiotherapy Alone for Pure and Mixed Anaplastic Oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402
	Gregory Cairncross, Brian Berkey, Edward Shaw, Robert Jenkins, Bernd Scheithauer, David Brachman, Jan Buckner, Karen Fink, Luis Souhami, Normand Laperierre, Minesh Mehta, and Walter Curran
	JCO Jun 20 2006: 2707–2714. [Abstract] [Full Text] [PDF]
	Adjuvant Procarbazine, Lomustine, and Vincristine Improves Progression-Free Survival but Not Overall Survival in Newly Diagnosed Anaplastic Oligodendrogliomas and Oligoastrocytomas: A Randomized European Organisation for Research and Treatment of Cancer Phase III Trial
	Martin J. van den Bent, Antoine F. Carpentier, Alba A. Brandes, Marc Sanson, Martin J.B. Taphoorn, Hans J.J.A. Bernsen, Marc Frenay, Cees C. Tijssen, Wolfgang Grisold, Laslo Sipos, Hanny Haaxma-Reiche, Johannes M. Kros, Mathilde C.M. van Kouwenhoven, Charles J. Vecht, Anouk Allgeier, Denis Lacombe, and Thierry Gorlia
	JCO Jun 20 2006: 2715–2722. [Abstract] [Full Text] [PDF] [Publisher's Note]

Genitourinary Cancer
	Celecoxib Versus Placebo for Men With Prostate Cancer and a Rising Serum Prostate-Specific Antigen After Radical Prostatectomy and/or Radiation Therapy
	Matthew R. Smith, Judith Manola, Donald S. Kaufman, William K. Oh, Glenn J. Bubley, and Philip W. Kantoff
	JCO Jun 20 2006: 2723–2728. [Abstract] [Full Text] [PDF]
	Phase II Trial of Intravesical Gemcitabine in Bacille Calmette-Guérin–Refractory Transitional Cell Carcinoma of the Bladder
	Guido Dalbagni, Paul Russo, Bernard Bochner, Leah Ben-Porat, Joel Sheinfeld, Pramod Sogani, Machelle S. Donat, Harry W. Herr, and Dean Bajorin
	JCO Jun 20 2006: 2729–2734. [Abstract] [Full Text] [PDF]
	Detection of Occult Lymph Node Metastases in Locally Advanced Node-Negative Prostate Cancer
	Vincenzo Pagliarulo, Debra Hawes, Frank H. Brands, Susan Groshen, Jie Cai, John P. Stein, Gary Lieskovsky, Donald G. Skinner, and Richard J. Cote
	JCO Jun 20 2006: 2735–2742. [Abstract] [Full Text] [PDF]

Breast Cancer
	Complete Excision of Primary Breast Tumor Improves Survival of Patients With Metastatic Breast Cancer at Diagnosis
	Elisabetta Rapiti, Helena M. Verkooijen, Georges Vlastos, Gerald Fioretta, Isabelle Neyroud-Caspar, André Pascal Sappino, Pierre O. Chappuis, and Christine Bouchardy
	JCO Jun 20 2006: 2743–2749. First published on May 15 2006; 10.1200/JCO.2005.04.2226. [Abstract] [Full Text] [PDF] [Russian PDF]
	Use and Outcomes of Adjuvant Chemotherapy in Older Women With Breast Cancer
	Sharon H. Giordano, Zhigang Duan, Yong-Fang Kuo, Gabriel N. Hortobagyi, and James S. Goodwin
	JCO Jun 20 2006: 2750–2756. [Abstract] [Full Text] [PDF]
	Adjuvant Chemotherapy and Survival in Older Women With Hormone Receptor–Negative Breast Cancer: Assessing Outcome in a Population-Based, Observational Cohort
	Elena B. Elkin, Arti Hurria, Nandita Mitra, Deborah Schrag, and Katherine S. Panageas
	JCO Jun 20 2006: 2757–2764. [Abstract] [Full Text] [PDF]
	Randomized Controlled Trial of Weight Training and Lymphedema in Breast Cancer Survivors
	Rehana L. Ahmed, William Thomas, Douglas Yee, and Kathryn H. Schmitz
	JCO Jun 20 2006: 2765–2772. First published on May 15 2006; 10.1200/JCO.2005.03.6749. [Abstract] [Full Text] [PDF] [Publisher's Note]
	Pegylated Liposomal Doxorubicin and Trastuzumab in HER-2 Overexpressing Metastatic Breast Cancer: A Multicenter Phase II Trial
	Stephen Chia, Mark Clemons, Lee-Ann Martin, Angela Rodgers, Karen Gelmon, Gregory R. Pond, and Lawrence Panasci
	JCO Jun 20 2006: 2773–2778. First published on May 8 2006; 10.1200/JCO.2005.03.8331. [Abstract] [Full Text] [PDF]
	Stroke Rates and Risk Factors in Patients Treated With Radiation Therapy for Early-Stage Breast Cancer
	Reshma Jagsi, Kent A. Griffith, Todd Koelling, Rachel Roberts, and Lori J. Pierce
	JCO Jun 20 2006: 2779–2785. First published on May 15 2006; 10.1200/JCO.2005.04.0014. [Abstract] [Full Text] [PDF]
	Randomized Phase III Study of Trastuzumab, Paclitaxel, and Carboplatin Compared With Trastuzumab and Paclitaxel in Women With HER-2–Overexpressing Metastatic Breast Cancer
	Nicholas Robert, Brian Leyland-Jones, Lina Asmar, Robert Belt, Des Ilegbodu, David Loesch, Robert Raju, Elizabeth Valentine, Robert Sayre, Melody Cobleigh, Kathy Albain, Cecelia McCullough, Lea Fuchs, and Dennis Slamon
	JCO Jun 20 2006: 2786–2792. [Abstract] [Full Text] [PDF]
	Quantitative Fluoroestradiol Positron Emission Tomography Imaging Predicts Response to Endocrine Treatment in Breast Cancer
	Hannah M. Linden, Svetlana A. Stekhova, Jeanne M. Link, Julie R. Gralow, Robert B. Livingston, Georgiana K. Ellis, Philip H. Petra, Lanell M. Peterson, Erin K. Schubert, Lisa K. Dunnwald, Kenneth A. Krohn, and David A. Mankoff
	JCO Jun 20 2006: 2793–2799. First published on May 8 2006; 10.1200/JCO.2005.04.3810. [Abstract] [Full Text] [PDF] [Publisher's Note]

Lung Cancer
	Phase III Study Comparing Oral Topotecan to Intravenous Docetaxel in Patients With Pretreated Advanced Non–Small-Cell Lung Cancer
	Rodryg Ramlau, Radj Gervais, Maciej Krzakowski, Joachim von Pawel, Eckhard Kaukel, Raymond P. Abratt, Bernie Dharan, Kelly M. Grotzinger, Graham Ross, Graham Dane, and Frances A. Shepherd
	JCO Jun 20 2006: 2800–2807. First published on May 8 2006; 10.1200/JCO.2005.03.6491. [Abstract] [Full Text] [PDF]
	The "Big Dog" Effect: Variability Assessing the Causes of Error in Diagnoses of Patients With Lung Cancer
	Stephen S. Raab, Frederick A. Meier, Richard J. Zarbo, D. Chris Jensen, Kim R. Geisinger, Christine N. Booth, Uma Krishnamurti, Chad H. Stone, Janine E. Janosky, and Dana M. Grzybicki
	JCO Jun 20 2006: 2808–2814. [Abstract] [Full Text] [PDF]

Supportive Care And Quality Of Life
	Sexual Problems in Younger Women After Breast Cancer Surgery
	Stephanie R. Burwell, L. Douglas Case, Carolyn Kaelin, and Nancy E. Avis
	JCO Jun 20 2006: 2815–2821. [Abstract] [Full Text] [PDF]
	Prospective Changes in Quality of Life After Ductal Carcinoma-in-Situ: Results From the Nurses' Health Study
	Larissa Nekhlyudov, Candyce H. Kroenke, Inkyung Jung, Michelle D. Holmes, and Graham A. Colditz
	JCO Jun 20 2006: 2822–2827. [Abstract] [Full Text] [PDF]
	Quality of Life and Pain in Advanced Stage Prostate Cancer: Results of a Southwest Oncology Group Randomized Trial Comparing Docetaxel and Estramustine to Mitoxantrone and Prednisone
	Donna L. Berry, Carol M. Moinpour, Caroline S. Jiang, Donna Pauler Ankerst, Daniel P. Petrylak, Lynne V. Vinson, Primo N. Lara, Sharon Jones, Mary E. Taplin, Patrick A. Burch, Maha H.A. Hussain, and E. David Crawford
	JCO Jun 20 2006: 2828–2835. [Abstract] [Full Text] [PDF]
	Phase III Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Black Cohosh in the Management of Hot Flashes: NCCTG Trial N01CC1
	Barbara A. Pockaj, James G. Gallagher, Charles L. Loprinzi, Philip J. Stella, Debra L. Barton, Jeff A. Sloan, Beth I. Lavasseur, Radha M. Rao, Tom R. Fitch, Kendrith M. Rowland, Paul J. Novotny, Patrick J. Flynn, Elliott Richelson, and Abdul H. Fauq
	JCO Jun 20 2006: 2836–2841. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	End-of-Life Decisions Among Cancer Patients Compared With Noncancer Patients in Flanders, Belgium
	Lieve Van den Block, Johan Bilsen, Reginald Deschepper, Greta Van Der Kelen, Jan L. Bernheim, and Luc Deliens
	JCO Jun 20 2006: 2842–2848. [Abstract] [Full Text] [PDF]

Melanoma
	Prospective Multi-Institutional Study of Reverse Transcriptase Polymerase Chain Reaction for Molecular Staging of Melanoma
	Charles R. Scoggins, Merrick I. Ross, Douglas S. Reintgen, R. Dirk Noyes, James S. Goydos, Peter D. Beitsch, Marshall M. Urist, Stephan Ariyan, B. Scott Davidson, Jeffrey J. Sussman, Michael J. Edwards, Robert C.G. Martin, Angela M. Lewis, Arnold J. Stromberg, Andrew J. Conrad, Lee Hagendoorn, Jeffrey Albrecht, and Kelly M. McMasters
	JCO Jun 20 2006: 2849–2857. [Abstract] [Full Text] [PDF]
	Utility of Computed Tomography and Magnetic Resonance Imaging Staging Before Completion Lymphadenectomy in Patients With Sentinel Lymph Node–Positive Melanoma
	Thomas A. Aloia, Jeffrey E. Gershenwald, Robert H. Andtbacka, Marcella M. Johnson, Christopher W. Schacherer, Chaan S. Ng, Janice N. Cormier, Jeffrey E. Lee, Merrick I. Ross, and Paul F. Mansfield
	JCO Jun 20 2006: 2858–2865. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Phase I/II Study of Cetuximab in Combination With Cisplatin or Carboplatin and Fluorouracil in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck
	Jean Bourhis, Fernando Rivera, Ricard Mesia, Ahmad Awada, Lionel Geoffrois, Christian Borel, Yves Humblet, Antonio Lopez-Pousa, Ricardo Hitt, M. Eugenia Vega Villegas, Lionel Duck, Dominique Rosine, Nadia Amellal, Armin Schueler, and Andreas Harstrick
	JCO Jun 20 2006: 2866–2872. First published on May 22 2006; 10.1200/JCO.2005.04.3547. [Abstract] [Full Text] [PDF]
	Phase III Randomized Trial of Very Accelerated Radiation Therapy Compared With Conventional Radiation Therapy in Squamous Cell Head and Neck Cancer: A GORTEC Trial
	Jean Bourhis, Michel Lapeyre, Jacques Tortochaux, Michel Rives, Mehdi Aghili, Sylvain Bourdin, François Lesaunier, Toufik Benassi, Claire Lemanski, Lionel Geoffrois, Antoine Lusinchi, Pierre Verrelle, Etienne Bardet, Morbize Julieron, Pierre Wibault, Monique Luboinski, and Ellen Benhamou
	JCO Jun 20 2006: 2873–2878. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Intensified Platinum Therapy Is an Ineffective Strategy for Improving Outcome in Pediatric Patients With Advanced Hepatoblastoma
	Marcio H. Malogolowkin, Howard Katzenstein, Mark D. Krailo, Zhengjia Chen, Laura Bowman, Marleta Reynolds, Milton Finegold, Brian Greffe, Jon Rowland, Kurt Newman, Richard B. Womer, Wendy B. London, and Robert P. Castleberry
	JCO Jun 20 2006: 2879–2884. [Abstract] [Full Text] [PDF]
	FCGR2A Polymorphism Is Correlated With Clinical Outcome After Immunotherapy of Neuroblastoma With Anti-GD2 Antibody and Granulocyte Macrophage Colony-Stimulating Factor
	Nai-Kong V. Cheung, Rebecca Sowers, Andrew J. Vickers, Irene Y. Cheung, Brian H. Kushner, and Richard Gorlick
	JCO Jun 20 2006: 2885–2890. First published on May 8 2006; 10.1200/JCO.2005.04.6011. [Abstract] [Full Text] [PDF]
	High-Risk Neuroblastoma Treated With Tandem Autologous Peripheral-Blood Stem Cell–Supported Transplantation: Long-Term Survival Update
	Rani E. George, Shuli Li, Cheryl Medeiros-Nancarrow, Donna Neuberg, Karen Marcus, Robert C. Shamberger, Michael Pulsipher, Stephan A. Grupp, and Lisa Diller
	JCO Jun 20 2006: 2891–2896. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Perioperative CA19-9 Levels Can Predict Stage and Survival in Patients With Resectable Pancreatic Adenocarcinoma
	Cristina R. Ferrone, Dianne M. Finkelstein, Sarah P. Thayer, Alona Muzikansky, Carlos Fernandez-del Castillo, and Andrew L. Warshaw
	JCO Jun 20 2006: 2897–2902. [Abstract] [Full Text] [PDF]
	Chemotherapy in Advanced Gastric Cancer: A Systematic Review and Meta-Analysis Based on Aggregate Data
	Anna D. Wagner, Wilfried Grothe, Johannes Haerting, Gerhard Kleber, Axel Grothey, and Wolfgang E. Fleig
	JCO Jun 20 2006: 2903–2909. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	Prognostic Value of Nodal Ratios in Node-Positive Breast Cancer
	Wendy A. Woodward, Vincent Vinh-Hung, Naoto T. Ueno, Yee Chung Cheng, Melanie Royce, Patricia Tai, Georges Vlastos, Anne Marie Wallace, Gabriel N. Hortobagyi, and Yago Nieto
	JCO Jun 20 2006: 2910–2916. [Abstract] [Full Text] [PDF]

ASCO SPECIAL ARTICLES
	American Society of Clinical Oncology Recommendations on Fertility Preservation in Cancer Patients
	Stephanie J. Lee, Leslie R. Schover, Ann H. Partridge, Pasquale Patrizio, W. Hamish Wallace, Karen Hagerty, Lindsay N. Beck, Lawrence V. Brennan, and Kutluk Oktay
	JCO Jun 20 2006: 2917–2931. First published on May 1 2006; 10.1200/JCO.2006.06.5888. [Abstract] [Full Text] [PDF] [Publisher's Note]
	American Society of Clinical Oncology Guideline for Antiemetics in Oncology: Update 2006
	Mark G. Kris, Paul J. Hesketh, Mark R. Somerfield, Petra Feyer, Rebecca Clark-Snow, James M. Koeller, Gary R. Morrow, Lawrence W. Chinnery, Maurice J. Chesney, Richard J. Gralla, and Steven M. Grunberg
	JCO Jun 20 2006: 2932–2947. First published on May 22 2006; 10.1200/JCO.2006.06.9591. [Abstract] [Full Text] [PDF] [Publisher's Note]

SPECIAL ARTICLE
	The Role of Prevention in Oncology Practice: Results From a 2004 Survey of American Society of Clinical Oncology Members
	Patricia A. Ganz, Lorna Kwan, Mark R. Somerfield, David Alberts, Judy E. Garber, Kenneth Offit, and Scott M. Lippman
	JCO Jun 20 2006: 2948–2957. First published on May 15 2006; 10.1200/JCO.2006.05.8321. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Treatment of Bicalutamide-Induced Gynecomastia With Breast-Reduction Surgery in Prostate Cancer

Mari Nakabayashi, Richard A. Bartlett, and William K. Oh

JCO Jun 20 2006: 2958–2959. [Full Text] [PDF]

Acute Coronary Syndrome Secondary to Fluorouracil Infusion

Jack I. Lu, Robert L. Carhart, Stephen L. Graziano, and Ajeet Gajra

JCO Jun 20 2006: 2959–2960. [Full Text] [PDF]

Thymoma Associated With Keratoconjunctivitis, Lichen Planus, Hypogammaglobinemia, and Absent Circulating B Cells

Charmaine Hon, Wing-Hung Chui, Lik-Cheung Cheng, Tony W. Shek, Brian M. Jones, and Wing Y. Au

JCO Jun 20 2006: 2960–2961. [Full Text] [PDF]

Small Cell Carcinoma of the Larynx in a Long-Term Survivor of Small-Cell Lung Cancer

Kyoichi Kaira, Tamotsu Ishizuka, Naondo Sohara, Noriko Yanagitani, Noriaki Sunaga, Takafumi Tsuchiya, and Masatomo Mori

JCO Jun 20 2006: 2961–2963. [Full Text] [PDF]

CORRESPONDENCE
	How Early Is Early: Androgen Deprivation for Prostate-Specific Antigen Relapse in Prostate Cancer
	Gillian M. Duchesne, Rodney Syme, and Deborah Howell
	JCO Jun 20 2006: 2964. [Full Text] [PDF]
	In Reply
	Charles J. Ryan
	JCO Jun 20 2006: 2965. [Full Text] [PDF]
	Research Supports the View that Sentinel Node Biopsy Is the Standard of Care in High-Risk Primary Melanoma
	Lutz Kretschmer and Reinhard Hilgers
	JCO Jun 20 2006: 2965-a–2966. [Full Text] [PDF]
	In Reply
	Joseph Meirion Thomas
	JCO Jun 20 2006: 2966–2967. [Full Text] [PDF]
	Thalidomide and Dexamethasone for Newly Diagnosed Multiple Myeloma: Is This Really the Standard of Care?
	Chadi Nabhan and Jacob D. Bitran
	JCO Jun 20 2006: 2967–2968. [Full Text] [PDF]
	In Reply
	Kenneth C. Anderson and Paul G. Richardson
	JCO Jun 20 2006: 2968–2969. [Full Text] [PDF]
	Communicating BRCA1 and BRCA2 Genetic Test Results
	Dorothea Gadzicki, Luzie U. Wingen, Birgitta Teige, Denise Horn, Kristin Bosse, Friedmar Kreuz, Timm Goecke, Dieter Schäfer, Theda Voigtländer, Barbara Fischer, Ursula Froster, Brigitte Welling, Irmgard Debatin, Bernard H. F. Weber, Ines Schönbuchner, Irmgard Nippert, and Brigitte Schlegelberger
	JCO Jun 20 2006: 2969–2970. [Full Text] [PDF]
	In Reply
	Andrea Farkas Patenaude, Michel Dorval, Lisa Digianni, Katherine A. Schneider, Anu Chittenden, and Judy E. Garber
	JCO Jun 20 2006: 2970–2971. [Full Text] [PDF]
	Carboplatin for Stage I Seminoma
	Timothy Gilligan, William K. Oh, and Philip W. Kantoff
	JCO Jun 20 2006: 2971–2972. [Full Text] [PDF]
	Non–Islet-Cell Tumor Induced Hypoglycemia in Patients With Advanced Gastrointestinal Stromal Tumor Possibly Worsened By Imatinib
	Paul Hamberg, Floris A. de Jong, Joke G. Boonstra, Jaap van Doorn, Jaap Verweij, and Stefan Sleijfer
	JCO Jun 20 2006: e30–31. [Full Text] [PDF]
	In Reply
	Patrick J. Loehrer and George J. Bosl
	JCO Jun 20 2006: e32–33. [Full Text] [PDF]

ERRATA

ERRATUM

JCO Jun 20 2006: 2973. [Full Text] [PDF]

ERRATUM

JCO Jun 20 2006: 2973-a. [Full Text] [PDF]

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