EDITORIAL

When Does the Presence of the Target Predict Response to the Targeted Agent?

Emily K. Bergsland

JCO Jan 10 2006: 213–216. First published on Dec 19 2005; 10.1200/JCO.2005.03.6913. [Full Text] [PDF]

ORIGINAL REPORTS
Gastrointestinal Cancer
	Impact of Vascular Endothelial Growth Factor-A Expression, Thrombospondin-2 Expression, and Microvessel Density on the Treatment Effect of Bevacizumab in Metastatic Colorectal Cancer
	Adrian M. Jubb, Herbert I. Hurwitz, Wei Bai, Eric B. Holmgren, Patti Tobin, A. Steven Guerrero, Fairooz Kabbinavar, Scott N. Holden, William F. Novotny, Gretchen D. Frantz, Kenneth J. Hillan, and Hartmut Koeppen
	JCO Jan 10 2006: 217–227. First published on Dec 19 2005; 10.1200/JCO.2005.01.5388. [Abstract] [Full Text] [PDF]
	Vascular Endothelial Growth Factor-D and Its Receptor VEGFR-3: Two Novel Independent Prognostic Markers in Gastric Adenocarcinoma
	Stefan Jüttner, Christoph Wißmann, Thomas Jöns, Michael Vieth, Johannes Hertel, Stephan Gretschel, Peter M. Schlag, Wolfgang Kemmner, and Michael Höcker
	JCO Jan 10 2006: 228–240. First published on Dec 12 2005; 10.1200/JCO.2004.00.3467. [Abstract] [Full Text] [PDF]
	Multipopulation Analysis of Polymorphisms in Five Mononucleotide Repeats Used to Determine the Microsatellite Instability Status of Human Tumors
	Olivier Buhard, Francesca Cattaneo, Yick Fu Wong, So Fan Yim, Eitan Friedman, Jean-François Flejou, Alex Duval, and Richard Hamelin
	JCO Jan 10 2006: 241–251. First published on Dec 5 2005; 10.1200/JCO.2005.02.7227. [Abstract] [Full Text] [PDF]
	New MUC1 Serum Immunoassay Differentiates Pancreatic Cancer From Pancreatitis
	David V. Gold, David E. Modrak, Zhiliang Ying, Thomas M. Cardillo, Robert M. Sharkey, and David M. Goldenberg
	JCO Jan 10 2006: 252–258. First published on Dec 12 2005; 10.1200/JCO.2005.02.8282. [Abstract] [Full Text] [PDF]
	Gene Expression Profiling of Localized Esophageal Carcinomas: Association With Pathologic Response to Preoperative Chemoradiation
	Rajyalakshmi Luthra, Tsung-Teh Wu, Madan G. Luthra, Julie Izzo, Enrique Lopez-Alvarez, Li Zhang, Jaime Bailey, Jeffrey H. Lee, Robert Bresalier, Asif Rashid, Stephen G. Swisher, and Jaffer A. Ajani
	JCO Jan 10 2006: 259–267. First published on Dec 12 2005; 10.1200/JCO.2005.03.3688. [Abstract] [Full Text] [PDF]

Tumor Biology
	EZH2 Expression Is Associated With High Proliferation Rate and Aggressive Tumor Subgroups in Cutaneous Melanoma and Cancers of the Endometrium, Prostate, and Breast
	Ingeborg M. Bachmann, Ole J. Halvorsen, Karin Collett, Ingunn M. Stefansson, Oddbjørn Straume, Svein A. Haukaas, Helga B. Salvesen, Arie P. Otte, and Lars A. Akslen
	JCO Jan 10 2006: 268–273. First published on Dec 5 2005; 10.1200/JCO.2005.01.5180. [Abstract] [Full Text] [PDF]

Neurooncology
	Tumor Necrosis Factor-–Induced Protein 3 As a Putative Regulator of Nuclear Factor-B–Mediated Resistance to O6-Alkylating Agents in Human Glioblastomas
	Markus Bredel, Claudia Bredel, Dejan Juric, George E. Duran, Ron X. Yu, Griffith R. Harsh, Hannes Vogel, Lawrence D. Recht, Adrienne C. Scheck, and Branimir I. Sikic
	JCO Jan 10 2006: 274–287. First published on Dec 19 2005; 10.1200/JCO.2005.02.9405. [Abstract] [Full Text] [PDF] [Supplementary Tables]

Melanoma
	High Frequency of Submicroscopic Hemizygous Deletion Is a Major Mechanism of Loss of Expression of PTEN in Uveal Melanoma
	Mohamed H. Abdel-Rahman, Ying Yang, Xiao-Ping Zhou, Elson L. Craig, Frederick H. Davidorf, and Charis Eng
	JCO Jan 10 2006: 288–295. First published on Dec 12 2005; 10.1200/JCO.2005.02.2418. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Array-Based Comparative Genomic Hybridization Analysis Reveals Recurrent Chromosomal Alterations and Prognostic Parameters in Primary Cutaneous Large B-Cell Lymphoma
	Remco Dijkman, Cornelis P. Tensen, Ekaterina S. Jordanova, Jeroen Knijnenburg, Juliette J. Hoefnagel, Aat A. Mulder, Carla Rosenberg, Anton K. Raap, Rein Willemze, Károly Szuhai, and Maarten H. Vermeer
	JCO Jan 10 2006: 296–305. First published on Dec 5 2005; 10.1200/JCO.2005.02.0842. [Abstract] [Full Text] [PDF]

Lung Cancer
	Evaluation of Two Phosphorylation Sites Improves the Prognostic Significance of Akt Activation in Non–Small-Cell Lung Cancer Tumors
	Junji Tsurutani, Junya Fukuoka, Hiroko Tsurutani, Joanna H. Shih, Stephen M. Hewitt, William D. Travis, Jin Jen, and Phillip A. Dennis
	JCO Jan 10 2006: 306–314. First published on Dec 5 2005; 10.1200/JCO.2005.02.4133. [Abstract] [Full Text] [PDF]

Sarcomas
	Prognostic Significance of Chromosome Aberrations in High-Grade Soft Tissue Sarcomas
	Fredrik Mertens, Ulf Strömberg, Anders Rydholm, Pelle Gustafson, Henrik C.F. Bauer, Otte Brosjö, and Nils Mandahl
	JCO Jan 10 2006: 315–320. First published on Dec 5 2005; 10.1200/JCO.2005.03.0999. [Abstract] [Full Text] [PDF]

CORRESPONDENCE

Effect of Adjuvant Trastuzumab on Pregnancy

Ashita M. Waterston and John Graham

JCO Jan 10 2006: 321–322. [Full Text] [PDF]

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