CELEBRATING 25 YEARS OF JCO

Commentary

What Constitutes "Improved Prognosis"?

George P. Canellos

JCO Apr 20 2008: 1913–1914. [Full Text] [PDF] [From JCO 1983]

EDITORIALS

The Multi-Institutional Phase I Study: Disadvantages Without Advantages?

Jaap Verweij, Ferry Eskens, and Maja de Jonge

JCO Apr 20 2008: 1915–1916. [Full Text] [PDF]

All Dex’ed Out With Nowhere to Go?

Peter C. Adamson and Jeffrey S. Barrett

JCO Apr 20 2008: 1917–1918. [Full Text] [PDF]

Optimizing Endocrine Therapy for Estrogen Receptor–Positive Breast Cancer: Treating the Right Patients for the Right Length of Time

Nancy U. Lin and Eric P. Winer

JCO Apr 20 2008: 1919–1921. First published on Mar 10 2008; 10.1200/JCO.2007.14.7744. [Full Text] [PDF]

Assessing the Measure of a New Drug: Is Survival the Only Thing That Matters?

Daniel J. Sargent and Daniel F. Hayes

JCO Apr 20 2008: 1922–1923. [Full Text] [PDF]

From Silos to a Critical Path of New Agent Development: A Paradigm to Revolutionize Clinical Research

Al B. Benson, III

JCO Apr 20 2008: 1924–1925. [Full Text] [PDF]

ORIGINAL REPORTS
Phase I and Clinical Pharmacology
	Multi-Institutional Phase I Trials of Anticancer Agents
	Afshin Dowlati, Sudhir Manda, Joseph Gibbons, Scot C. Remick, Lauren Patrick, and Pingfu Fu
	JCO Apr 20 2008: 1926–1931. [Abstract] [Full Text] [PDF]
	Asparaginase May Influence Dexamethasone Pharmacokinetics in Acute Lymphoblastic Leukemia
	Lei Yang, John C. Panetta, Xiangjun Cai, Wenjian Yang, Deqing Pei, Cheng Cheng, Nancy Kornegay, Ching-Hon Pui, and Mary V. Relling
	JCO Apr 20 2008: 1932–1939. [Abstract] [Full Text] [PDF]
	Phase I Study of MGCD0103 Given As a Three-Times-Per-Week Oral Dose in Patients With Advanced Solid Tumors
	Lillian L. Siu, Roberto Pili, Ignacio Duran, Wells A. Messersmith, Eric X. Chen, Rana Sullivan, Martha MacLean, Serina King, Shirley Brown, Gregory K. Reid, Zuomei Li, Ann M. Kalita, Eric J. Laille, Jeffrey M. Besterman, Robert E. Martell, and Michael A. Carducci
	JCO Apr 20 2008: 1940–1947. [Abstract] [Full Text] [PDF]

Breast Cancer
	Late Extended Adjuvant Treatment With Letrozole Improves Outcome in Women With Early-Stage Breast Cancer Who Complete 5 Years of Tamoxifen
	Paul E. Goss, James N. Ingle, Joseph L. Pater, Silvana Martino, Nicholas J. Robert, Hyman B. Muss, Martine J. Piccart, Monica Castiglione, Lois E. Shepherd, Kathleen I. Pritchard, Robert B. Livingston, Nancy E. Davidson, Larry Norton, Edith A. Perez, Jeffrey S. Abrams, David A. Cameron, Michael J. Palmer, and Dongsheng Tu
	JCO Apr 20 2008: 1948–1955. First published on Mar 10 2008; 10.1200/JCO.2007.11.6798. [Abstract] [Full Text] [PDF]
	Efficacy, Toxicity, and Quality of Life in Older Women With Early-Stage Breast Cancer Treated With Letrozole or Placebo After 5 Years of Tamoxifen: NCIC CTG Intergroup Trial MA.17
	Hyman B. Muss, Dongsheng Tu, James N. Ingle, Silvana Martino, Nicholas J. Robert, Joseph L. Pater, Timothy J. Whelan, Michael J. Palmer, Martine J. Piccart, Lois E. Shepherd, Kathleen I. Pritchard, Zhi He, and Paul E. Goss
	JCO Apr 20 2008: 1956–1964. First published on Mar 10 2008; 10.1200/JCO.2007.12.6334. [Abstract] [Full Text] [PDF]
	Benefit From Exemestane As Extended Adjuvant Therapy After 5 Years of Adjuvant Tamoxifen: Intention-to-Treat Analysis of the National Surgical Adjuvant Breast and Bowel Project B-33 Trial
	Eleftherios P. Mamounas, Jong-Hyeon Jeong, D. Lawrence Wickerham, Roy E. Smith, Patricia A. Ganz, Stephanie R. Land, Andrea Eisen, Louis Fehrenbacher, William B. Farrar, James N. Atkins, Eduardo R. Pajon, Victor G. Vogel, Joan F. Kroener, Laura F. Hutchins, André Robidoux, James L. Hoehn, James N. Ingle, Charles E. Geyer, Jr, Joseph P. Costantino, and Norman Wolmark
	JCO Apr 20 2008: 1965–1971. First published on Mar 10 2008; 10.1200/JCO.2007.14.0228. [Abstract] [Full Text] [PDF]
	Letrozole Compared With Tamoxifen for Elderly Patients With Endocrine-Responsive Early Breast Cancer: The BIG 1-98 Trial
	Diana Crivellari, Zhuoxin Sun, Alan S. Coates, Karen N. Price, Beat Thürlimann, Henning Mouridsen, Louis Mauriac, John F. Forbes, Robert J. Paridaens, Monica Castiglione-Gertsch, Richard D. Gelber, Marco Colleoni, István Láng, Lucia Del Mastro, Laurence Gladieff, Manuela Rabaglio, Ian E. Smith, Jacquie H. Chirgwin, and Aron Goldhirsch
	JCO Apr 20 2008: 1972–1979. First published on Mar 10 2008; 10.1200/JCO.2007.14.0459. [Abstract] [Full Text] [PDF]
	Taxanes Alone or in Combination With Anthracyclines As First-Line Therapy of Patients With Metastatic Breast Cancer
	Martine J. Piccart-Gebhart, Tomasz Burzykowski, Marc Buyse, George Sledge, James Carmichael, Hans-Joachim Lück, John R. Mackey, Jean-Marc Nabholtz, Robert Paridaens, Laura Biganzoli, Jacek Jassem, Marijke Bontenbal, Jacques Bonneterre, Stephen Chan, Gul Atalay Basaran, and Patrick Therasse
	JCO Apr 20 2008: 1980–1986. [Abstract] [Full Text] [PDF]
	Evaluation of Tumor Response, Disease Control, Progression-Free Survival, and Time to Progression As Potential Surrogate End Points in Metastatic Breast Cancer
	Tomasz Burzykowski, Marc Buyse, Martine J. Piccart-Gebhart, George Sledge, James Carmichael, Hans-Joachim Lück, John R. Mackey, Jean-Marc Nabholtz, Robert Paridaens, Laura Biganzoli, Jacek Jassem, Marijke Bontenbal, Jacques Bonneterre, Stephen Chan, Gul Atalay Basaran, and Patrick Therasse
	JCO Apr 20 2008: 1987–1992. [Abstract] [Full Text] [PDF]
	Phase II Trial of Lapatinib for Brain Metastases in Patients With Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer
	Nancy U. Lin, Lisa A. Carey, Minetta C. Liu, Jerry Younger, Steven E. Come, Matthew Ewend, Gordon J. Harris, Elizabeth Bullitt, Annick D. Van den Abbeele, John W. Henson, Xiaochun Li, Rebecca Gelman, Harold J. Burstein, Elizabeth Kasparian, David G. Kirsch, Ann Crawford, Fred Hochberg, and Eric P. Winer
	JCO Apr 20 2008: 1993–1999. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Systematic Survey of Therapeutic Trials for Metastatic Colorectal Cancer: Room for Improvement in the Critical Pathway
	Scott Kopetz, Michael Overman, David Z. Chang, Katrina Y. Glover, Imad Shureiqi, Robert A. Wolff, James L. Abbruzzese, and Cathy Eng
	JCO Apr 20 2008: 2000–2005. [Abstract] [Full Text] [PDF]
	Randomized Phase III Study of Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid Plus Oxaliplatin As First-Line Therapy for Metastatic Colorectal Cancer
	Jim Cassidy, Stephen Clarke, Eduardo Díaz-Rubio, Werner Scheithauer, Arie Figer, Ralph Wong, Sheryl Koski, Mikhail Lichinitser, Tsai-Shen Yang, Fernando Rivera, Felix Couture, Florin Sirzén, and Leonard Saltz
	JCO Apr 20 2008: 2006–2012. [Abstract] [Full Text] [PDF]
	Bevacizumab in Combination With Oxaliplatin-Based Chemotherapy As First-Line Therapy in Metastatic Colorectal Cancer: A Randomized Phase III Study
	Leonard B. Saltz, Stephen Clarke, Eduardo Díaz-Rubio, Werner Scheithauer, Arie Figer, Ralph Wong, Sheryl Koski, Mikhail Lichinitser, Tsai-Shen Yang, Fernando Rivera, Felix Couture, Florin Sirzén, and Jim Cassidy
	JCO Apr 20 2008: 2013–2019. [Abstract] [Full Text] [PDF] [Publisher's Note]

Supportive Care and Quality of Life
	Validation of Patient's Self-Reported Social Functioning As an Independent Prognostic Factor for Survival in Metastatic Colorectal Cancer Patients: Results of an International Study by the Chronotherapy Group of the European Organisation for Research and Treatment of Cancer
	Fabio Efficace, Pasquale F. Innominato, Georg Bjarnason, Corneel Coens, Yves Humblet, Salvatore Tumolo, Dominique Genet, Marco Tampellini, Andrew Bottomley, Carlo Garufi, Christian Focan, Sylvie Giacchetti, and Francis Lévi
	JCO Apr 20 2008: 2020–2026. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Cognitive and Academic Consequences of Stem-Cell Transplantation in Children
	Sean Phipps, Shesh N. Rai, Wing-Hang Leung, Shelly Lensing, and Maggi Dunavant
	JCO Apr 20 2008: 2027–2033. [Abstract] [Full Text] [PDF]

Immunotherapy
	Phase I Study of Recombinant Interleukin-21 in Patients With Metastatic Melanoma and Renal Cell Carcinoma
	John A. Thompson, Brendan D. Curti, Bruce G. Redman, Shailender Bhatia, Jeffrey S. Weber, Sanjiv S. Agarwala, Eric L. Sievers, Steven D. Hughes, Todd A. DeVries, and Diana F. Hausman
	JCO Apr 20 2008: 2034–2039. First published on Mar 17 2008; 10.1200/JCO.2007.14.5193. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Eosinophilia With FIP1L1-PDGFRA Fusion in a Patient With Chronic Myelomonocytic Leukemia

Victor Zota, Patricia M. Miron, Bruce A. Woda, Azra Raza, and Sa A. Wang

JCO Apr 20 2008: 2040–2041. [Full Text] [PDF] [Publisher's Note]

Intracranial Collision Metastases of Small-Cell Lung Cancer and Malignant Melanoma

Kevin T. Palka, Richard L. Lebow, Kyle D. Weaver, and Megan K. Kressin

JCO Apr 20 2008: 2042–2046. [Full Text] [PDF]

Major Response to Imatinib Mesylate in KIT-Mutated Melanoma

F. Stephen Hodi, Philip Friedlander, Christopher L. Corless, Michael C. Heinrich, Suzanne Mac Rae, Andrea Kruse, Jyothi Jagannathan, Annick D. Van den Abbeele, Elsa F. Velazquez, George D. Demetri, and David E. Fisher

JCO Apr 20 2008: 2046–2051. [Full Text] [PDF]

CORRESPONDENCE

Trastuzumab-Related Cardiotoxicity in the Herceptin Adjuvant Trial

Filippo Montemurro, Stefania Redana, Giorgio Valabrega, Rossella Martinello, Massimo Aglietta, and Renato Palmiero

JCO Apr 20 2008: 2052–2053. [Full Text] [PDF]

In Reply

Thomas M. Suter, Marion Procter, and Martine J. Piccart

JCO Apr 20 2008: 2053–2054. [Full Text] [PDF]

Targeting Pelvic Lymph Nodes in Men With Intermediate- and High-Risk Prostate Cancer Despite Two Negative Randomized Trials

Paul L. Nguyen and Anthony V. D'Amico

JCO Apr 20 2008: 2055–2056. [Full Text] [PDF]

In Reply

Pascal Pommier and Sylvie Chabaud

JCO Apr 20 2008: 2056–2057. [Full Text] [PDF]

Reaction to American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer

Rene Bernards

JCO Apr 20 2008: 2057–2058. [Full Text] [PDF]

Inconsistent Criteria Used in American Society of Clinical Oncology 2007 Update of Recommendations for the Use of Tumor Markers in Breast Cancer

Fatima Cardoso, Mahasti Saghatchian, Alastair Thompson, Emiel Rutgers for the TRANSBIG Consortium Steering Committee

JCO Apr 20 2008: 2058–2059. [Full Text] [PDF]

In Reply

Lyndsay N. Harris, Daniel F. Hayes, and Robert C. Bast

JCO Apr 20 2008: 2060–2061. [Full Text] [PDF]

Temporal Changes in Quality of Life (QoL) of Patients With Primary Brain Tumors: Raw QoL Data From a Randomized Trial as Reference for Future Studies

Dirk Vordermark

JCO Apr 20 2008: 2061–2062. [Full Text] [PDF]

In Reply

Martin J.B. Taphoorn, Martin J. van den Bent, Murielle Mauer, and Andrew Bottomley

JCO Apr 20 2008: 2062. [Full Text] [PDF]

Reporting of Subset Analysis: Where Do We Draw the Line?

Sanjay Goel

JCO Apr 20 2008: 2062-a–2063. [Full Text] [PDF]

Improved Survival With Addition of Bevacizumab to Paclitaxel and Carboplatin in Elderly Patients With Non–Small-Cell Lung Cancer

Carl D. Atkins

JCO Apr 20 2008: 2063–2064. [Full Text] [PDF]

Meaningful Subset Analyses Contribute to Optimal Patient Care

Suresh S. Ramalingam, Suzanne E. Dahlberg, Robert Gray, Corey J. Langer, Chandra P. Belani, Julie R. Brahmer, Alan B. Sandler, Joan H. Schiller, and David H. Johnson

JCO Apr 20 2008: 2064–2065. [Full Text] [PDF]

ERRATA

ERRATUM

JCO Apr 20 2008: 2066. [Full Text] [PDF]

ERRATUM

JCO Apr 20 2008: 2066-a. [Full Text] [PDF]

ERRATUM

JCO Apr 20 2008: 2066-b. [Full Text] [PDF]

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